Congenital smooth muscle hamartoma

Copi, Luana Rocco Pereira; Peraro, Thaís de Freitas; Copi, Igor; Caldas, Adriana Cristina

doi:10.1590/abd1806-4841.20198249

Cited by 5 publications

(7 citation statements)

References 2 publications

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“…Although the etiopathogenesis of the SMH remains unclear, cases can be divided into two groups: congenital 1,5,9,10,16‐24 and acquired SMH 2‐4,6‐8,11,12,15,25‐32 . Eleven of our cases (41%) presented as a congenital lesion, most commonly located on the torso and lower extremity (six cases, 55%) followed by the upper extremity (two cases, 18%) and the head and neck area (two cases, 18%), and one case (9%) was located on the penile shaft.…”

Section: Discussionmentioning

confidence: 88%

“…Clinically, SMH most commonly presents as a papule/plaque/nodule, 3,4,[9][10][11][12] which may or may not be hyperpigmented, [5][6][7][8]16,18,20,30 or with hypertrichosis, 17,19,24 or as a "cystic" lesion. 2,22,23 In 17 of our cases (63%), the smooth muscle proliferation was closely related to a pilosebaceous unit which could potentially explain the hypertrichosis in some of these lesions, and one can hypothesize that perhaps the arrectores pilorum muscles are the culprits in these cases.…”

Section: Striated Muscle Hamartomamentioning

confidence: 99%

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Smooth muscle hamartoma and striated muscle hamartoma: Clinicopathologic characterization of two rare entities and literature review

González

Dehner

2020

J Cutan Pathol

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Smooth muscle hamartoma (SMH) and striated muscle hamartoma (STH) are anomalous proliferations of smooth muscle or striated muscle, respectively, in anatomic sites where these tissues are normally present. To date, only limited cases have been reported describing these lesions. In this study, we sought to characterize the clinicopathologic features of both SMH and STH. A total of 27 cases of SMH and 12 cases of STH from 1990 to 2020 were identified. SMH cases had a slight male predominance (63%) and a mean age of presentation of 20 years (range: 4 months‐91 years), with a mean size of 9.3 mm (±13.3). In contrast, STH were equally distributed in gender, with a mean age of presentation of 40 years (range: 3 months‐66 years) and a mean size of 5.7 mm (±3.6). SMH were more commonly located in the torso and extremities (70%) and STH in the head and neck area (92%). One case of SMH recurred after 1.1 years and in the initial diagnosis the lesion was present at the tissue edge. None of the cases of STH had a recurrence. We present the largest cohort of SMH and STH, and report the first case of a recurrent SMH, suggesting the importance of obtaining a clean margin for these lesions.

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Section: Discussionmentioning

confidence: 88%

Section: Striated Muscle Hamartomamentioning

confidence: 99%

Smooth muscle hamartoma and striated muscle hamartoma: Clinicopathologic characterization of two rare entities and literature review

González

Dehner

2020

J Cutan Pathol

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“…This sign helps clinically distinguish congenital smooth muscle hamartoma from congenital hairy nevus. [4,5] Literature search on PubMed for ocular and periocular congenital smooth muscle hamartomas yielded the aforementioned cases. To our knowledge, this is the first reported case of a congenital smooth muscle hamartoma originating in the bulbar conjunctival/limbal tissue.…”

Section: Discussionmentioning

confidence: 99%

“…This sign helps clinically distinguish congenital smooth muscle hamartoma from congenital hairy nevus. [ 4 , 5 ]…”

Section: Discussionmentioning

confidence: 99%

Congenital Smooth Muscle Hamartoma Obscuring the Cornea

Bean

Al-Bouri

Bradford

et al. 2021

Case Reports in Ophthalmological Medicine

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Congenital smooth muscle hamartoma is a benign proliferation of smooth muscle that most commonly presents in the lumbosacral area or proximal extremities. Although exceedingly rare, congenital smooth muscle hamartomas have been reported to occur in ocular structures such as the brow, eyelid, and conjunctival fornix. This case describes an atypical congenital bulbar lesion in a newborn male which obscured the cornea. The lesion, which appeared to originate from the bulbar conjunctiva and/or the limbus, was excised at 5 months of age. Pathologic evaluation was consistent with congenital smooth muscle hamartoma. The authors of this report believe it is the first to describe a patient with a congenital smooth muscle hamartoma of the bulbar conjunctiva/limbus.

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“…The appearance is variable and may demonstrate hyperpigmentation, hypertrichosis, and/or epidermal changes in the form of perifollicular papules. [1][2][3] When biopsied, discrete, variably oriented hyperplastic smooth muscle bundles are found in the reticular dermis. 3 CSMHs are thought to originate from the arrector pili muscles, blood vessel walls, or from specialized smooth muscle of the genitals, given the normal distribution of smooth muscle.…”

Section: Introductionmentioning

confidence: 99%