Clinicopathologic discordance: Congenital smooth muscle hamartoma clinically mimics reticulated vascular lesion

Schrom, Kory P; Shah, Sonal D.; Rohr, Bethany R.

doi:10.1016/j.jdcr.2022.05.036

Cited by 5 publications

(3 citation statements)

References 9 publications

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“…Because of several case reports with multiple Becker's nevi 3,4 , in the current case, Becker's nevi were considered as a potential differential diagnosis. However, due to the absence of hypertrichosis and the lack of epidermal changes, the present case is reasonably diagnosed as SMH 5 . Based on our current understanding, there have been a few case reports of multiple SMH in localized areas of the body, such as the head and scrotum 6,7 .…”

Section: Discussionmentioning

confidence: 70%

A Case of Multiple Acquired Depressed Smooth Muscle Hamartoma

Chiba,

Dekio,

Uno

et al. 2023

Preprint

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Section: Discussionmentioning

confidence: 70%

A Case of Multiple Acquired Depressed Smooth Muscle Hamartoma

Chiba,

Dekio,

Uno

et al. 2023

Preprint

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“…See below). An element of absolute surprise is inherent in the definition: an example could be a congenital smooth muscle hamartoma clinically presenting as a vascular lesion, a finding labelled with the usual, yet vague (see above) term of "clinicopathologic discordance" by the scholars who have described it [4]. These authors use the term only in the title, and it turns out as implicitly amenable to attributes such as "clinically mimicking" or "masquerading" elsewhere in the title and in the body of the paper.…”

Section: The Problem: "Discrepancies" "Inconsis-tencies" "Mimickers" ...mentioning

confidence: 99%

Clinicopathologic Dissociation in Dermat[onc]ology – and Beyond

Capella

2022

J. Can. Res. Updates

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The concept of clinicopathologic dissociation is a neglected one in medicine. It refers to the unexpected, complete absence of concordance between the clinical picture and the underlying histopathologic finding. The recognition of such a phenomenon generally implies radically different treatment and follow-up choices. A rare phenomenon, it can however be encountered, especially in the field of dermatoncology and dermatology at large. It should be kept separate from clinicopathologic discordance or discrepancy, the term used by surgical pathologists to indicate the lack of expected molecular markers or to the presence of unexpected ones in the face of a given morphological diagnosis, albeit overlaps occur. More generally, the concept of clinicopathologic dissociation can be applied when a given clinical manifestation appears completely unrelated to the underlying objectively tracked primary disease. Examples are provided, and educational, ethical and medicolegal implications are briefly discussed.

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“…Therefore, we diagnosed this case as a smooth muscle hamartoma of the lung based on the increase in the number of smooth muscle cells in several components. In humans, smooth muscle hamartoma is a benign proliferation of smooth muscle cells that are mainly derived from the arrector pili muscle in the dermis 18 , 19 . A similar lesion has been reported in dogs as a hamartoma of the arrector pili muscles 20 .…”

mentioning

confidence: 99%

Smooth muscle hamartoma of the lungs in a Wistar Hannover rat

MIYAZAKI¹,

FUJIWARA²,

KATOH³

et al. 2023

J Toxicol Pathol

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Hamartomas are tumor-like masses comprising disorganized normal tissue elements. To date, spontaneous hamartomas have been reported in several organs and tissues in rodents but not in the lungs. Here, we report the first case of a hamartoma in the lungs of a 108-week-old female Wistar Hannover rat. Grossly, a white spot, 7 mm in diameter, was observed on the costal surface of the left lung. Histopathologically, the nodular lesions adjacent to the bronchioles comprised mature smooth muscle cells. The lesion was not encapsulated and spread along the alveolar walls and ducts without compression of the surrounding tissue. In the nodules, elastic fibers enclosed small lumens lined with factor VIII-related antigen-positive endothelial cells. This structure suggested that the nodule mimicked an artery. Moreover, structural abnormalities were observed within the bronchioles and arterioles owing to the increased number of smooth muscle cells in the surrounding tissues. These features suggested that this was a case of tissue malformation rather than a neoplasm, leading to the diagnosis of a smooth muscle hamartoma of the lung.

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Clinicopathologic discordance: Congenital smooth muscle hamartoma clinically mimics reticulated vascular lesion

Cited by 5 publications

References 9 publications

A Case of Multiple Acquired Depressed Smooth Muscle Hamartoma

A Case of Multiple Acquired Depressed Smooth Muscle Hamartoma

Clinicopathologic Dissociation in Dermat[onc]ology – and Beyond

Smooth muscle hamartoma of the lungs in a Wistar Hannover rat

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