Positive results of patch tests with fragrance markers: analysis of a 15-year period at a Brazilian dermatology center

Abstract

Fragrances may cause allergic contact dermatitis. Data on patients who were patch tested, between 2000 and 2015, with fragrance allergens included in the Brazilian baseline series (balsam of Peru, colophony and fragrance mix I), were collected and analyzed. Of these patients, 258 (13.8%) were positive for fragrance markers, 9.8% being positive for fragrance mix I. Among these 258 there was a predominance of women in their 40s, with hand eczema. The frequency of sensitization to fragrances, as well as the epidemiological profile, was supported by the literature. Fragrance mix I was the main marker. It is important to expand the fragrance markers used in the Brazilian baseline series of patch tests.

Allergic contact dermatitis to cosmetics: retrospective analysis of a population subjected to patch tests between 2004 and 2017

“…A study by the same group that studied fragrance sensitization, published in 2018, showed 10% of concurrent positive tests. 12 …”

Sensitization to Fragrance mix-1 in Patients with Contact Dermatitis in Nord-East of Italy: 1996–2016 Time Trend and Gender Effect

“…After metals, sensitization to fragrance mix-1 is high in Europe ranging between 6 to 14% in patients with contact dermatitis, with wide variability between countries [1][2][3][4]. Austria presented the highest prevalence in Europe (13.63%; 95% CI 11.57-15.1) in the period 2009-2012 [1] and Spain, the lowest (4.7% in Silvestre et al [2] in 2018), while in Brazil, Hafter et al in 2018 [5] reported a prevalence of 9.8%. Sensitization to fragrance mix-1 is highly dependent on the age of patients tested, and percentages can be completely different in relation to the presence of pediatric population.…”