Metastatic pleomorphic dermal sarcoma: an uncommon skin tumour

Kravvas, Georgios; Veitch, David; Logan, Ian T.; Perrett, Conal M.

doi:10.1590/abd1806-4841.20187228

Cited by 5 publications

(11 citation statements)

References 5 publications

(11 reference statements)

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“…Our report of the metastatic disease development in 2/17 patients (12%) is reflective of the malignant potential of this dermal neoplasm, falling midway between 2 and 19% of previous studies 12–16 . Metastasis to the lung was noted in both patients, which is established as the most common site for distant metastasis in soft‐tissue sarcomas (STS) 13,17,26 . The main limitation of our study is the small sample size, and lower limit of clinical follow‐up period of 31 months for surviving patients.…”

Section: Discussionmentioning

confidence: 68%

“…Clearance was achieved in two patients (case 2 and 9) with no further local recurrence. Case 2 developed biopsy proven metastatic disease at 7 months and has been reported previously 17 . Case 7 had deep margin involvement of the local recurrence WLE and was treated with adjuvant radiotherapy 50Gy in 30# over 12 weeks without further recurrence.…”

Section: Resultsmentioning

confidence: 74%

“…Case 2 developed biopsy proven metastatic disease at 7 months and has been reported previously. 17 Case 7 had deep margin involvement of the local recurrence WLE and was treated with adjuvant radiotherapy 50Gy in 30# over 12 weeks without further recurrence. Case 12 developed local recurrence and multiple nodules of in‐transit metastasis.…”

Section: Resultsmentioning

confidence: 99%

“…Miller et al and Tardio et al both used ‘deep subcutaneous invasion’ as inclusion criteria for their case series but the requirement for ‘deep invasion’ is absent from the published WHO classifications 2,12,13,25 . The relevance of diagnostic dichotomisation is primarily the recognition of the higher likelihood of local recurrence, distant metastasis and tumour related mortality with which PDS is associated in comparison to AFX 1,6,12,13,17 . The common pattern for progressive disease is multiple cutaneous metastases and lung parenchymal disease which is typical of haematogenous dissemination of sarcoma 12,13 …”

Section: Discussionmentioning

confidence: 99%

“… 2 , 12 , 13 , 25 The relevance of diagnostic dichotomisation is primarily the recognition of the higher likelihood of local recurrence, distant metastasis and tumour related mortality with which PDS is associated in comparison to AFX. 1 , 6 , 12 , 13 , 17 The common pattern for progressive disease is multiple cutaneous metastases and lung parenchymal disease which is typical of haematogenous dissemination of sarcoma. 12 , 13 …”

Section: Discussionmentioning

confidence: 99%

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Pleomorphic dermal sarcoma: Clinicopathological features and outcomes from a 5‐year tertiary referral centre experience

et al. 2021

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Background Pleomorphic dermal sarcoma (PDS) describes rare dermal‐based malignant tumours that are morphologically similar to atypical fibroxanthoma (AFX). PDS may be differentiated from AFX by the presence of one or more of the following histologic features: subcutaneous invasion, tumour necrosis, lymphovascular invasion (LVI), and/or perineural infiltration (PNI). Aims To further define the clinicopathological features, surgical management, and outcomes of PDS primary tumours. Methods and Results This study was a retrospective observational case series using a database search from 2012 to 2017. Inclusion criteria required all cases to meet the histopathologic criteria for PDS as confirmed by a specialist soft‐tissue histopathologist. A total of n = 17 cases were included with a median age of 78 years (range 66–85). All tumours were located on the head and neck, with 13/17 located on the scalp. Primary treatment was with wide local excision (WLE) in all cases. Median follow‐up was 48 months. Local recurrence occurred in 4/17 cases (24%) and distant metastasis in 2/17 cases (12%). Conclusion PDS behaves more aggressively than atypical fibroxanthoma with which it shares a biologic continuum. The optimal surgical management approach is yet to be determined.

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Section: Discussionmentioning

confidence: 68%

Section: Resultsmentioning

confidence: 74%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Pleomorphic dermal sarcoma: Clinicopathological features and outcomes from a 5‐year tertiary referral centre experience

et al. 2021

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Pleomorphic Dermal Sarcoma With Metastasis to the Lung: A Case Report

Shafi

Bechtel

Plaza

2023

The American Journal of Dermatopathology

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Atypical fibroxanthoma and pleomorphic dermal sarcoma (PDS) are dermal malignant mesenchymal tumors that lie at the ends of the same disease spectrum. Clinically indistinguishable from atypical fibroxanthoma, PDS has a more aggressive course with significantly higher rate of local recurrence and metastases. Histological findings that favor a PDS include subcutaneous invasion, tumor necrosis, lymphovascular invasion, and/or perineural infiltration. Herein, we report a case of PDS with metastasis to the lung. Our report highlights the risk of local recurrence and metastatic spread in this cutaneous tumor and the importance of distinguishing this entity from its less aggressive counterpart.

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