Pemphigus foliaceus with pustular presentation in a patient with psoriasis

Abstract

Pemphigus foliaceus is a chronic autoimmune disease of the skin, clinically characterized by scaly and crusty cutaneous erosions involving the seborrheic areas. The patient can eventually become erythrodermic. There are reports of atypical cases of pemphigus foliaceus with pustules and neutrophils, and clinical differentiation from generalized pustular psoriasis of von Zumbusch is difficult. We report the case of a 55-year-old man with a history of psoriasis vulgaris that has developed pemphigus foliaceus with pustules, triggered by withdrawal of systemic corticosteroids. This is the first report associating this atypical form of pemphigus with psoriasis, suggesting that an overlap with generalized pustular psoriasis can occur.

Increase in primary cilia in the epidermis of patients with atopic dermatitis and psoriasis

“…Dsg1 expression is lacking in cases with severe AD 42 . In previous report, Dsg1 was shown to be involved in psoriasis associated with pemphigus foliaceus 43 . Stimulation of NHEK with IL‐13, IL‐17 and IL‐22 was shown to decrease Dsg1 in both normal or IFT88 downregulated NHEK.…”

Implication of phototherapy for rare comorbidity of psoriasis and pemphigus foliaceus: Case report and review of literature

“…Our review suggests that psoriasis tends to precede PF occurrence (Table 1). [1][2][3][4][5][6][7] We also found that PF developed after phototherapy in four patients. Kwon reported that the inflammatory process triggered by NB-UVB could facilitate interactions between desmoglein antigens and the immune system.…”

“…Whether there is a common pathomechanism underlying psoriasis and PF is unclear. [1][2][3][4][5][6][7] Psoriasis is an inflammatory, T cell-dependent disease. 2 PF is an autoimmune bullous disease due to pathogenic autoantibodies targeting Dsg-1.…”