An overview about oxidation in clinical practice of skin aging

Abstract

Free radicals are unstable chemical species, highly reactive, being formed by cellular entities of different tissues. Increased production of these species without proper effective action of endogenous and exogenous antioxidant systems, generates a condition of oxidative stress, potentially provider of skin disorders that extend from functional impairments (skin cancer, dermatitis, chronic and acute inflammatory processes) even aesthetic character, with the destruction of structural proteins and cellular changes with the appearance of stains, marks and lines of expressions and other signs inherent to the intrinsic and extrinsic skin aging process. The antioxidants are chemical substances commonly used in clinical practice for topical application and may contribute in the fight against the radical species responsible for many skin damage. This paper summarized the main evidence of the benefits brought by the topical application of antioxidants in the skin, considering the amplitude of the indicative performance of antioxidant activity by in vitro and ex-vivo tests as well as in vivo tests. It is recognized that a breadth of product performance tests should be explored to truly identify the effectiveness of antioxidant products for an anti-aging effect.

The effects of vitamins and selenium mixture against brain tissue induced byd‐galactosamine

“…The activity of cellular components can produce high levels of reactive chemical species, termed free radicals; these substances are highly unstable and chemically reactive . Free radical chain reactions are initiated by ROS.…”

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“…Thus, the protection of lipid oxidation is important, since many products have limited shelf life due to oxidation of the excipients, which may result in alteration of their fragrance and color. [50] Antioxidants neutralize damaging free radicals thus protecting cells from both.…”

Chemical Constituents, Antioxidant, Anti-MMPs, and Anti-Hyaluronidase Activities of Thunbergia laurifolia Lindl. Leaf Extracts for Skin Aging and Skin Damage Prevention

“…Skin ageing resulting from the effects of environmental factors is known as extrinsic skin ageing, whereas skin ageing due to the passage of time is known as intrinsic skin ageing [3]. Imbalances in free radicals and proper effective action of endogenous antioxidant systems generate a condition of oxidative stress and leads to skin functional impairment, e.g., destruction of structural proteins [4]. Theses cellular changes result in signs inherent to both the intrinsic and extrinsic skin aging processes [4].…”

“…Imbalances in free radicals and proper effective action of endogenous antioxidant systems generate a condition of oxidative stress and leads to skin functional impairment, e.g., destruction of structural proteins [4]. Theses cellular changes result in signs inherent to both the intrinsic and extrinsic skin aging processes [4]. Collagen, a major extracellular matrix component in the dermis providing tensile strength, substantially changes with age [5].…”