Cutaneous angiosarcoma: report of three different and typical cases admitted in a unique dermatology clinic

Abstract

Angiosarcoma is a rare and aggressive tumor with high rates of metastasis and relapse. It shows a particular predilection for the skin and superficial soft tissues. We report three distinct and typical cases of angiosarcoma that were diagnosed in a single dermatology clinic over the course of less than a year: i) Angiosarcoma in lower limb affected by chronic lymphedema, featuring Stewart-Treves syndrome; ii) a case of the most common type of angiosarcoma loated in the scalp and face of elderly man and; iii) a skin Angiosarcoma in previously irradiated breast. All lesions presented characteristic histopathological findings: irregular vascular proliferation that dissects the collagen bundles with atypical endothelial nuclei projection toward the lumen.

A peculiar uncommon cutaneous neoplasia: Angiosarcoma of the head and neck of the elderly (Wilson Jones Angiosarcoma)

“…[5,6,9] For these tumors, the literature reports the following immunohistochemical panel (Erg +, claudin 5 +, vimentin +, CD31 +, FL1 +, D2-40 +, VEGFR variable, Keratin variable, CD34 +/-, prox 1+/-, vWF -/+, EMA -and S-100 -). [7,11,12] In this particular neoplasia to date, no characteristic chromosomal aberration has been signaled. According to Manner et al in post-irradiation skin angiosarcomas or associated with lymphedema, an amplification of the MYC gene would occur, which would not occur in primitive angiosarcomas.…”

A new case of scalp angiosarcoma revealed by eyelid edema

“…However, cAS may mimic eczema, rosacea, hemangioma, or cellulitis, leading to delay in diagnosis [3,4]. Although case reports of eyelid and periocular lesions, as in our patient, have been reported, they are rare [5].…”