Aryl hydrocarbon receptor overexpression in miniaturized follicles in female pattern hair loss

Ramos, Paulo Müller; Brianezi, Gabrielli; Martins, Ana Carolina Pereira; Silva, Márcia Guimarães da; Marques, Mariângela Esther Alencar; Miot, Hélio Amante

doi:10.1590/abd1806-4841.20175150

Cited by 5 publications

(4 citation statements)

References 10 publications

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“…Oxidative stress, perifollicular microinflammation, and microvascular insufficiency have been reported as factors associated with AGA. 72 , 73 Goldman et al observed that in AGA, bald areas have lower oxygen (O 2 ) levels than non-bald ones, suggesting some degree of microvascular insufficiency. 74 Moreover, the conversion of testosterone into DHT preferentially occurs in an O 2 -poor medium, and therefore, an increased blood supply would reduce local hypoxia and thus could be beneficial in the treatment of AGA.…”

Section: Methodsmentioning

confidence: 99%

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Female-pattern hair loss: therapeutic update

Ramos¹,

Fernandes²,

Radwanski³

et al. 2023

Anais Brasileiros de Dermatologia

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Section: Methodsmentioning

confidence: 99%

“… 1 In addition to the role of androgens, most clearly demonstrated in male AGA, there is evidence of the participation of genetic, hormonal, and environmental elements. 1 , 3 , 4 …”

Section: Introductionmentioning

confidence: 99%

Female-pattern hair loss: therapeutic update

Ramos¹,

Fernandes²,

Radwanski³

et al. 2023

Anais Brasileiros de Dermatologia

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“…The effects of pollutants on skin barrier and ECM homeostasis have been widely reported but effects on hair follicles and scalp skin have been poorly characterized. Ramos PM has reported that AhR overexpression in the nucleus was observed in miniaturized hair follicles in female pattern hair loss [12].…”

Section: Introductionmentioning

confidence: 99%

The Potential Application of Ecklonia cava Extract in Scalp Protection

et al. 2020

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The scalp is exposed to environmental hazards including airborne pollutants, which exert adverse effects on skin health. Therefore, compounds for defending skin from pollutants have attracted interest in the cosmeceutical community. We investigated whether Ecklonia cava exhibited prophylactic effects against urban pollutants by measuring cell viability and cell cycle distribution in human follicle dermal papilla cells (HFDPC). The effect of E. cava on pollutant-induced damage to skin barrier was determined by measuring filaggrin and MMP-1 expression in both keratinocytes and in a skin explant model. In a clinical trial, the effect of E. cava on scalp skin of patients with scalp scale was observed by evaluating hydration and redness after 4 weeks of daily treatment with a shampoo containing E. cava extract. E. cava extract recovered the loss of cell viability and abnormal cell cycle distribution induced by urban pollutants in HFDPCs. It also attenuated pollutant-induced damage to skin barrier by decreasing MMP-1 and increasing filaggrin expression in keratinocytes and the epidermis of skin explants. Moreover, E. cava showed soothing effects on human scalp by increasing hydration and decreasing redness in a clinical trial. Collectively, E. cava extract may be a good candidate for therapeutic applications designed to repair or protect hair scalp.

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“…It is characterized by progressive follicular miniaturization of unclear etiology, but it is influenced by multiple factors such as genetic predisposition, hormonal and environmental changes, being sun exposure and smoking among them. 1 - 3 …”

Section: Introductionmentioning

confidence: 99%

Translation into Portuguese language (Brazil), transcultural adaptation and validation of the quality of life questionnaire in female pattern hair loss (WAA-QoL-BP)

Shimizu

Wedy

Schaefer

et al. 2018

An. Bras. Dermatol.

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BackgroundFemale pattern hair loss (FPHL) is a common complaint in adult women and inflicts major impact in quality of life, however, there is no specific questionnaire available in Portuguese for such evaluation.ObjectivesTranslation into Brazilian Portuguese, cultural adaptation and validation of the WAA-QoL (Women's Androgenetic Alopecia Quality of Life Questionnaire).MethodsMethodological study. After authorization by the author, cultural (linguistic) translation and adaptation to Portuguese of the WAA-QoL questionnaire were carried out. The translated version (WAA-QoL-BP) and DLQI (Dermatology Life Quality index) were submitted to patients with FPHL for concurrent validation. Twenty patients were reevaluated to assess temporal stability.ResultsA total of 116 patients with APF were evaluated, the mean age (SD) was 47 (14) years, and 89 (76%) patients were classified as grades II and III (Sinclair). There was high internal consistency: Cronbach´s alpha was 0.97 for the WAA-QoL-BP and 0.87 for the DLQI. The correlation between WAA-QoL and DLQI resulted in (rho) 0.81 (p <0.01). The intraclass correlation coefficient for complete agreement of WAA-QoL-BP was 0.95 (p <0.01) in the test-retest comparison.Study LimitationsSampling of patients only from the State of São Paulo.ConclusionsA Brazilian version for WAA-QoL was translated and adapted, which proved to be valid and consistent.

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Aryl hydrocarbon receptor overexpression in miniaturized follicles in female pattern hair loss

Cited by 5 publications

References 10 publications

Female-pattern hair loss: therapeutic update

Female-pattern hair loss: therapeutic update

The Potential Application of Ecklonia cava Extract in Scalp Protection

Translation into Portuguese language (Brazil), transcultural adaptation and validation of the quality of life questionnaire in female pattern hair loss (WAA-QoL-BP)

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