Exuberant pyoderma gangrenosum in a patient with autoimmune hepatitis

Dantas, S.G.; Quintella, Leonardo Pereira; Fernandes, Nurimar Conceição

doi:10.1590/abd1806-4841.20174871

Cited by 2 publications

(1 citation statement)

References 9 publications

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“…In another cohort, these drugs were initiated in 81.8% of the patients ( n = 9); after 60 months, only two patients had been recurrence free, while the others had multiple recurrences, treated with sulfamethoxazole and trimethoprim, minocycline, topical corticosteroids, and cyclophosphamide 54 . In addition, corticosteroids and local treatment were preferred when PG was associated with autoimmune diseases, such as autoimmune hepatitis 55 …”

Section: Resultsmentioning

confidence: 99%

Pyoderma gangrenosum: a review with special emphasis on Latin America literature

Rodríguez-Zúñiga

Heath

Gontijo

et al. 2019

Anais Brasileiros de Dermatologia

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Pyoderma gangrenosum is a neutrophilic dermatosis characterized by chronic ulcers due to an abnormal immune response. Despite the existence of diagnostic criteria, there is no gold standard for diagnosis or treatment. In Latin America, recognizing and treating pyoderma gangrenosum is even more challenging since skin and soft tissue bacterial and non-bacterial infections are common mimickers. Therefore, this review aims to characterize reported cases of pyoderma gangrenosum in this region in order to assist in the assessment and management of this condition. Brazil, Mexico, Argentina, and Chile are the countries in Latin America that have reported the largest cohort of patients with this disease. The most frequent clinical presentation is the ulcerative form and the most frequently associated conditions are inflammatory bowel diseases, inflammatory arthropaties, and hematologic malignancies. The most common treatment modalities include systemic corticosteroids and cyclosporine. Other reported treatments are methotrexate, dapsone, and cyclophosphamide. Finally, the use of biological therapy is still limited in this region.

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Section: Resultsmentioning

confidence: 99%

Pyoderma gangrenosum: a review with special emphasis on Latin America literature

Rodríguez-Zúñiga

Heath

Gontijo

et al. 2019

Anais Brasileiros de Dermatologia

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Skin Manifestations Associated with Autoimmune Liver Diseases: a Systematic Review

Beretta‐Piccoli

Invernizzi

Gershwin

et al. 2017

Clinic Rev Allerg Immunol

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Autoimmune liver diseases, which include mainly autoimmune hepatitis, primary biliary cholangitis, primary sclerosing cholangitis, and the variant syndromes, are often associated with extrahepatic autoimmune diseases. However, the association with cutaneous diseases is less well described. In the present article, we provide a systematic literature review on skin manifestations linked to each of these four autoimmune liver diseases, excluding skin manifestations of systemic diseases. The association of autoimmune hepatitis with vitiligo is well known, with a particular striking association with type 2 autoimmune hepatitis, a condition occurring almost entirely in children and adolescents, much rarer and more aggressive than type 1 autoimmune hepatitis; probable associations are also identified with alopecia areata, psoriasis, and pyoderma gangrenosum. Primary biliary cholangitis is not linked to lichen planus as previously assumed, but to vitiligo, psoriasis and the very rare amicrobial pustulosis of the folds. The proposed diagnostic criteria for this latter condition include the presence of anti-mitochondrial autoantibodies, the serological hallmark of primary biliary cholangitis. The very strong association of primary sclerosing cholangitis with inflammatory bowel diseases hampers the search for an association with skin diseases, since inflammatory bowel diseases have a strong association with various dermatological condition, including neutrophilic dermatoses and erythema nodosum. Nevertheless, a probable association of primary sclerosing cholangitis with psoriasis is identified in this review. Variant syndromes, also called overlap syndromes, are likely associated with vitiligo as well, which is not surprising, since autoimmune hepatitis is a feature of these conditions and they may share regions of the MHC.

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Exuberant pyoderma gangrenosum in a patient with autoimmune hepatitis

Cited by 2 publications

References 9 publications

Pyoderma gangrenosum: a review with special emphasis on Latin America literature

Pyoderma gangrenosum: a review with special emphasis on Latin America literature

Skin Manifestations Associated with Autoimmune Liver Diseases: a Systematic Review

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