Iatrogenic Kaposi's sarcoma caused by corticosteroids

Lazzarini, Rosana; Lopes, Andressa Sato de Aquino; Lellis, Rute Facchini; Brasil, Fabiana

doi:10.1590/abd1806-4841.20165772

Cited by 4 publications

(2 citation statements)

References 5 publications

(7 reference statements)

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“…Four clinical and epidemiological subtypes have been described: the classic or Mediterranean, endemic, epidemic AIDS-related, and iatrogenic. Iatrogenic KS occurs in patients exposed to long-term immunosuppressive treatments (topical or oral corticosteroids and/or other immunosuppressants) associated or not with organ transplantation [2][3][4][5][6][7][8]. It often raises the problem of managing the disease for which the immunosuppressant was prescribed because of the need to discontinue the drug or reduce the dose.…”

Section: Introductionmentioning

confidence: 99%

Muriel Sidnoma Ouédraogo, Nakougou Moϊ-Bohm Biatougou, Nomtondo Amina Ouédraogo, Angèle Ouangré/Ouédraogo, Gilbert Patrice Marie Louis Tapsoba, Adama Traoré, Fatimata Cissé, Nina Korsaga/Somé, Pascal Niamba, Jacques Simporé, Adama Traoré

Ouédraogo¹,

Biatougo²,

Ouédraogo³

et al. 2023

Our Dermatol Online

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Kaposi’s sarcoma is a multifocal angiogenic tumor disease whose principal causal agent is human herpes virus 8 (HHV-8). Herein, we report a rare case of iatrogenic Kaposi’s sarcoma developing during oral corticotherapy. A 76-year-old, HIV-negative male presented with papulous, angiomatous lesions on the trunk and limbs, which appeared three months after the beginning of oral corticotherapy for bullous pemphigoid. We suspected iatrogenic Kaposi’s sarcoma given the time to lesion onset in relation to the immunosuppressive treatment, together with histological and virological confirmation of HHV-8. The lesions began to subside when corticosteroids were tapered down to 10 mg/day. This was the first case reported in our setting and it emphasized the need for the rigorous monitoring of patients receiving immunosuppressants to avoid overlooking the side effects or rare complications of these treatments. Key words: Kaposi’s sarcoma; Oral corticotherapy; HHV-8; Bullous pemphigoid

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Section: Introductionmentioning

confidence: 99%

Muriel Sidnoma Ouédraogo, Nakougou Moϊ-Bohm Biatougou, Nomtondo Amina Ouédraogo, Angèle Ouangré/Ouédraogo, Gilbert Patrice Marie Louis Tapsoba, Adama Traoré, Fatimata Cissé, Nina Korsaga/Somé, Pascal Niamba, Jacques Simporé, Adama Traoré

Ouédraogo¹,

Biatougo²,

Ouédraogo³

et al. 2023

Our Dermatol Online

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“…However, immune dysregulation appears to be a common factor in all forms of KS development. For instance, HIV-associated (epidemic) KS is usually a consequence of severe immunocompromise [ 3 ], Iatrogenic KS is a result of immunosuppressive therapy [ 4 ], while Classical KS affects elderly men [ 5 ] who likely have compromised immunity due to aging [ 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

Cells of the Innate and Adaptive Immune Systems in Kaposi’s Sarcoma

Ngalamika

Munsaka

2020

Journal of Immunology Research

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Kaposi’s sarcoma (KS) is an angioproliferative malignancy whose associated etiologic agent is the Kaposi’s sarcoma-associated herpesvirus (KSHV). KS is the most prevalent malignancy among HIV-infected individuals globally and is considered an AIDS-defining malignancy. The different forms of KS including HIV-associated KS, iatrogenic (immunosuppression-related) KS, and classical KS in elderly males suggest that immune cell dysregulation is among the key components in promoting KS development in KSHV-infected individuals. It is therefore expected that different cell types of the immune system likely play distinct roles in promoting or inhibiting KS development. This narrative review is focused on discussing cells of the innate and adaptive immune systems in KSHV infection and KS pathogenesis, including how these cells can be useful in the control of KSHV infection and treatment of KS.

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Prednisone

2017

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Iatrogenic Kaposi's sarcoma caused by corticosteroids

Cited by 4 publications

References 5 publications

Muriel Sidnoma Ouédraogo, Nakougou Moϊ-Bohm Biatougou, Nomtondo Amina Ouédraogo, Angèle Ouangré/Ouédraogo, Gilbert Patrice Marie Louis Tapsoba, Adama Traoré, Fatimata Cissé, Nina Korsaga/Somé, Pascal Niamba, Jacques Simporé, Adama Traoré

Muriel Sidnoma Ouédraogo, Nakougou Moϊ-Bohm Biatougou, Nomtondo Amina Ouédraogo, Angèle Ouangré/Ouédraogo, Gilbert Patrice Marie Louis Tapsoba, Adama Traoré, Fatimata Cissé, Nina Korsaga/Somé, Pascal Niamba, Jacques Simporé, Adama Traoré

Cells of the Innate and Adaptive Immune Systems in Kaposi’s Sarcoma

Prednisone

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