When strength turns into disease: acne fulminans in a bodybuilder

Pérez, Mario; Navajas-Galimany, Lucas; Antúnez-Lay, Andrea; Hasson, Ariel

doi:10.1590/abd1806-4841.20165345

Cited by 13 publications

(6 citation statements)

References 5 publications

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“…54 Anabolic steroids trigger acne through targeting androgen receptors on sebocytes and keratinocytes. [55][56][57][58] Other medical treatments. Corticosteroids, halogens, isoniazid, lithium, vitamin B12, immunosuppressants and certain anticancer agents and radiotherapy have been reported causing acneiform eruptions.…”

Section: Acne Exposome Factorsmentioning

confidence: 99%

The influence of exposome on acne

Dréno

Bettoli

Araviiskaia

et al. 2018

Acad Dermatol Venereol

102

103

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Background Acne vulgaris is one of the main reasons for dermatological consultations. Severity and response to treatment may be impacted by various external factors or exposome.AimTo assess the impact of environmental factors on acne and to provide a comprehensive overview of the acne exposome.MethodsTwo consensus meetings of five European dermatologists and a comprehensive literature search on exposome factors triggering acne served as a basis for this review.ResultsAcne exposome was defined as the sum of all environmental factors influencing the occurrence, duration and severity of acne. Exposome factors impact on the response and the frequency of relapse to treatments by interacting with the skin barrier, sebaceous gland, innate immunity and cutaneous microbiota. They may be classified into the following six main categories: nutrition, psychological and lifestyle factors, occupational factors including cosmetics, as well as pollutants, medication and climatic factors. Moreover, practical considerations for the dermatologist's clinical practice are proposed.ConclusionExposome factors including nutrition, medication, occupational factors, pollutants, climatic factors, and psychosocial and lifestyle factors may impact on the course and severity of acne and on treatment efficacy. Identifying and reducing the impact of exposome is important for an adequate acne disease management.

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Section: Acne Exposome Factorsmentioning

confidence: 99%

The influence of exposome on acne

Dréno

Bettoli

Araviiskaia

et al. 2018

Acad Dermatol Venereol

102

103

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“…1 Different external and internal factors, including air pollution, aggressive skincare products, medication, mechanical, hormonal and familial factors and, more recently, lifestyle and stress, have been suggested as having an impact on acne. [2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18] Even if for many years nutrition was believed to cause or worsen acne, it has become a dermatological doctrine over the last decades that there is no direct association between diet and acne. [19][20][21][22][23][24] Cordain et al 25 were the first to question this belief, by studying acne-free populations having no hyperglycaemic carbohydrate and no dairy product intake.…”

Section: Introductionmentioning

confidence: 99%

“…Acne is an inflammatory and multifactorial skin disease . Different external and internal factors, including air pollution, aggressive skincare products, medication, mechanical, hormonal and familial factors and, more recently, lifestyle and stress, have been suggested as having an impact on acne …”

Section: Introductionmentioning

confidence: 99%

Acne and nutrition: hypotheses, myths and facts

Claudel¹,

Auffret²,

Leccia

et al. 2018

Acad Dermatol Venereol

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Acne is an inflammatory and multifactorial skin disease. Different external and internal factors, including air pollution, aggressive skincare products, medication, mechanical, hormonal and familial factors and, more recently, lifestyle and stress, have been suggested as having an impact on acne. Moreover, for many years nutrition was believed to cause or worsen acne. Over the last decades, however, it has become a dermatological doctrine that there is no direct association between diet and acne. Even if recent research has allowed to identify certain nutritional elements and behaviour that may impact on acne, including the excessive intake of dairy products and hyperglycaemic food, modern lifestyle nutrition, obesity and eating disorders, knowledge about the role of nutrition in the physiopathology of acne still remains sparse and hypotheses and myths continue to dominate the debate. Thus, further clinical and translational research is necessary to investigate and confirm the association between nutrition and acne.

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“…2,3,4 Recientemente se realizó una nueva clasificación estableciéndose 4 situaciones clínicas diferentes: acné fulminans con síntomas sistémicos, inducido o no, por isotretinoína y acné fulminans sin síntomas sistémicos, inducido o no, por isotretinoína. 5 En pacientes chilenos, pudimos identificar 2 casos publicados en la literatura 6 , y de acuerdo al registro clínico en nuestro Hospital Universitario, se han diagnosticado solo 2 casos de acné fulminans en los últimos 3 años.…”

Section: A 1bunclassified

“…Se han propuesto como factores de riesgo el aumento en los niveles sanguíneos de testosterona, como ocurre en: el tratamiento de talla baja, consumo de anabólicos e hiperplasia adrenal congénita de inicio tardío. 6 Se ha asociado también a posibles factores genéticos en casos de acné fulminans familiar. En relación a los casos inducidos por isotretinoína, se han identificado como factores de riesgo el inicio de la terapia en dosis altas en acné inflamatorio severo y la presencia de macrocomedones.…”

Section: A 1bunclassified

Acné fulminans inducido por isotretinoína, un desafío terapéutico

Armijo-Fernández

Molina²

2019

Rev. chil. dermatol

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El acné fulminans es una variante infrecuente y muy severa de acné inflamatorio.El inicio de isotretinoína en dosis altas en acné inflamatorio severo y la presencia de macrocomedones cerrados, son gatillantes conocidos de acné fulminans inducido por isotretinoína.Presentamos el caso de un paciente con acné inflamatorio moderado y múltiples comedones cerrados, que inició tratamiento con isotretinoína, desarrollando un cuadro de acné inflamatorio muy severo, asociado a fiebre y alteraciones de laboratorio, el cual fue compatible con acné fulminans con síntomas sistémicos inducido por isotretinoina. Acne fulminans is an infrequent and very severe variant of inflammatory acné. A high initiating dose of isotretinoin in severe inflammatory acné, and the presence of macrocomedones, are well-known triggers of isotretinoin-induced acné fulminans.We report the case of a patient with moderate inflammatory acné, with multiple macrocomedones who started a treatment on isotretinoin developing extremely severe inflammatory acné, fever and laboratory abnormalities, that was compatible with isotretinoin-induced acné fulminans with systemic symtoms.

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When strength turns into disease: acne fulminans in a bodybuilder

Cited by 13 publications

References 5 publications

The influence of exposome on acne

The influence of exposome on acne

Acne and nutrition: hypotheses, myths and facts

Acné fulminans inducido por isotretinoína, un desafío terapéutico

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