El acné fulminans es una variante infrecuente y muy severa de acné inflamatorio.El inicio de isotretinoína en dosis altas en acné inflamatorio severo y la presencia de macrocomedones cerrados, son gatillantes conocidos de acné fulminans inducido por isotretinoína.Presentamos el caso de un paciente con acné inflamatorio moderado y múltiples comedones cerrados, que inició tratamiento con isotretinoína, desarrollando un cuadro de acné inflamatorio muy severo, asociado a fiebre y alteraciones de laboratorio, el cual fue compatible con acné fulminans con síntomas sistémicos inducido por isotretinoina. Acne fulminans is an infrequent and very severe variant of inflammatory acné. A high initiating dose of isotretinoin in severe inflammatory acné, and the presence of macrocomedones, are well-known triggers of isotretinoin-induced acné fulminans.We report the case of a patient with moderate inflammatory acné, with multiple macrocomedones who started a treatment on isotretinoin developing extremely severe inflammatory acné, fever and laboratory abnormalities, that was compatible with isotretinoin-induced acné fulminans with systemic symtoms.
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