Ovarian carcinoma presenting as cutaneous nasal metastasis

António, Ana Marta; Alves, João; Goulão, João; Bártolo, Elvira

doi:10.1590/abd1806-4841.20165024

Cited by 8 publications

(11 citation statements)

References 6 publications

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“…1 CM may rarely be present at the time of diagnosis of an internal malignancy. While single case reports of various cancers with cutaneous metastasis have been reported, [2][3][4][5] longitudinal retrospective or prospective studies of patients with malignancies should be undertaken to delineate malignancies commonly presenting with cutaneous metastasis and their respective clinical presentations. Our study aims to examine the clinical and morphological presentation, and histological subtypes of CM seen in a tertiary healthcare institution.…”

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confidence: 99%

“…2 This proposal is also consistent with stem cell theory that melanomas could develop from quiescent precursor cells that have accumulated a malignant complement of mutations. 3 Any model proposed for melanomas developing from nevi, at best, can only be applied to a minority of melanomas, being fundamentally flawed for the vast majority which are known to develop de novo.…”

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confidence: 99%

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Cutaneous Metastasis: A Study of 138 Cases Diagnosed by Fine-Needle Aspiration Cytology

Handa¹,

Kundu²,

Dimri

2016

Acta Cytologica

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Background: Cutaneous metastases can occur in a wide variety of internal malignancies and may be the first sign of a clinically silent visceral cancer. Study Design: A retrospective analysis was made of 138 cases diagnosed with cutaneous and subcutaneous metastasis on fine-needle aspiration cytology (FNAC). Primary tumors of the skin/subcutis were excluded. Results: Of 138 cases, the primary was known in 101 cases and unknown in 37 cases. The age of the patients ranged from 5 to 86 years, and 76 (55.1%) were male and 62 (44.9%) were female. Clinically, the most common lesion was a single nodule (n = 77, 55.8%). The chest wall was the predominant site (n = 53, 38.4%). In males and females, the most common primary sites were the lung (n = 16) and breast (n = 24), respectively. On cytology, the most common diagnosis was metastatic adenocarcinoma (n = 41, 29.7%). Of 37 cases with an unknown primary, FNAC helped to locate the primary site in 17 (45.9%) cases, while in 20 cases it remained undiagnosed. Conclusions: FNAC is a rapid and safe technique that can be used as a first line of investigation for confirmation of metastatic lesions of the skin. Critical evaluation of cytomorphological features along with relevant clinical details could help in the localization of an unknown primary site in some cases.

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confidence: 99%

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confidence: 99%

Cutaneous Metastasis: A Study of 138 Cases Diagnosed by Fine-Needle Aspiration Cytology

Handa¹,

Kundu²,

Dimri

2016

Acta Cytologica

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show abstract

“…CM may rarely be present at the time of diagnosis of an internal malignancy. While single case reports of various cancers with cutaneous metastasis have been reported, longitudinal retrospective or prospective studies of patients with malignancies should be undertaken to delineate malignancies commonly presenting with cutaneous metastasis and their respective clinical presentations. Our study aims to examine the clinical and morphological presentation, and histological subtypes of CM seen in a tertiary healthcare institution.…”

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confidence: 99%

Cutaneous metastasis: experience from a tertiary healthcare institution in Singapore

et al. 2017

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“…Literature also shows that cancer can also progress to the skin and metastasize through the hematogenous and lymphatic pathway. [ 5 , 8 – 22 ] We present an overview of the current literature relating to ovarian cancer with skin metastasis in Table 1 . The most common metastatic site of ovarian cancer is the umbilicus area.…”

Section: Discussionmentioning

confidence: 99%

“…Nasal metastasis as a first symptom of ovarian cancer has also been reported. [ 22 ] In addition, ovarian cancer can metastasize to the skin of the chest and breast, back, vulvovaginal area, arms, and thighs.…”

Section: Discussionmentioning

confidence: 99%

Two independent incidences of skin metastases in the umbilicus and abdominal wall in ovarian serous adenocarcinoma

Cheng

Gao²,

Zhang³

et al. 2017

Medicine

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Rationale:Advanced ovarian cancer is usually associated with intra-abdominal metastases and while it commonly spreads directly to the omentum, intestine, liver, or other organs, it can also metastasize through the lymphatic channels and the hematogenous pathway. With an increasing number of invasive operations being performed with chemoradiotherapy, the incidence of extra-abdominal metastases has risen. Nevertheless, ovarian cancer with skin metastases is quite rare.Patient concerns:We report a case of ovarian cancer with two independent incidences of skin metastases in the umbilicus and abdominal wall.Diagnoses:The patient was a 67-year-old woman who was diagnosed with ovarian cancer stage IIIC and underwent cytoreductive surgery. A solitary brown cauliflower-like metastatic lesion, approximately 6 × 5 × 4 cm was identified in the umbilicus area two years after primary surgery. During tumorectomy, intraoperative exploration revealed that while the tumor was located close to the peritoneum, there was no penetration.Interventions:The patient recovered well and received multiple rounds of chemotherapy. Ten months later, the patient presented with skin lesions located on the abdominal wall that grew rapidly and spread from the lower abdomen wall to the bilateral waist and femoral skin. These lesions were multiple, ulcerated, rough heliotrope plaques that produced a foul-smelling faint yellow liquid. Biopsy analysis revealed skin metastasis of poorly differentiated serous adenocarcinoma.Outcomes:The patient was treated with chemotherapy but died 3 months after the skin metastasis occurred for the second time.Lessons:Ovarian cancer with skin metastasis is a rare condition with poor prognosis. Pathological diagnosis of early skin lesions is essential for ovarian cancer patients and that systemic and local disease should be treated with surgery or palliative therapy in order to provide patients with the best chances of survival. Tumorectomy is appropriate when lesions are isolated and when the patient's performance status is good. However, systemic therapy including chemotherapy and radiotherapy should be considered when skin lesions are associated with severe intro-abdominal disease.

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Ovarian carcinoma presenting as cutaneous nasal metastasis

Cited by 8 publications

References 6 publications

Cutaneous Metastasis: A Study of 138 Cases Diagnosed by Fine-Needle Aspiration Cytology

Cutaneous Metastasis: A Study of 138 Cases Diagnosed by Fine-Needle Aspiration Cytology

Cutaneous metastasis: experience from a tertiary healthcare institution in Singapore

Two independent incidences of skin metastases in the umbilicus and abdominal wall in ovarian serous adenocarcinoma

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