Non-melanoma skin cancer in Portuguese kidney transplant recipients - incidence and risk factors

Pinho, André; Gouveia, Miguel; Cardoso, José Carlos; Xavier, Maria Manuel; Vieira, Ricardo; Alves, Rui

doi:10.1590/abd1806-4841.20164891

Cited by 17 publications

(24 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…KCs are known to be associated with states of immune perturbation (29,32,48,49). In contrast, we found that cases and controls were similar in relation to use of immunosuppressive therapy.…”

Section: Discussioncontrasting

confidence: 72%

Modifiable Risk-factors for Keratinocyte Cancers in Australia: A Case-control Study

Higuita¹,

Harrison²,

Büttner³

et al. 2019

Acta Derm Venerol

View full text Add to dashboard Cite

This is an open access article under the CC BY-NC license. www.medicaljournals.se/acta Acta Derm Venereol 2019; 99: 404-411 404 SIGNIFICANCE This study examined the complex interplay between environmental and host risk-factors for keratinocyte cancer. The results show that increasing age, lower academic qualifications, freckling during adolescence, solar lentiginous, propensity to sunburn and high-cumulative sun-exposure increase the risk of keratinocyte cancer. Keratinocyte cancer is the most common malignancy in Caucasians. The aim of this study was to investigate risk-factors responsible for development of keratinocyte cancer in Australia. A case-control study was conducted, including 112 cases of squamous cell carcinoma (SCC), 95 cases of basal cell carcinoma (BCC) and 122 controls. Freckling during adolescence (SCC: odds ratio (OR) 1.04, p < 0.01; BCC: OR 1.05, p < 0.01), propensity to sunburn (SCC: OR 2.75, p = 0.01, BCC: OR 2.68 p = 0.01) and high cumulative sun-exposure (SCC: OR 2.43, p = 0.04; BCC: OR 2.36 p = 0.04) were independent risk-factors for both SCC and BCC. This study provides further evidence that a sun-sensitive phenotype and excessive sun-exposure during adulthood contribute to the risk of developing keratinocyte cancer. Wearing a hat, long-sleeved shirts, and sunscreen did not significantly reduce the risk of keratinocyte cancer in this study.

show abstract

Section: Discussioncontrasting

confidence: 72%

Modifiable Risk-factors for Keratinocyte Cancers in Australia: A Case-control Study

Higuita¹,

Harrison²,

Büttner³

et al. 2019

Acta Derm Venerol

View full text Add to dashboard Cite

show abstract

“…The included studies were published between 1980 and 2017; the Metastasis squamous cell carcinoma Table 2 Details of studies regarding special locations or high-risk tumours Metastasis squamous cell carcinoma number of included patients ranged from 34 to 796 (Table 1). [42][43][44][45][46][47][48][49][50][51][52][53][54][55][56][57] These studies were performed in the USA, New Zealand, Australia, The Netherlands, France, Portugal and Israel. Follow-up in these studies was mainly calculated from time of transplantation instead of follow-up from cSCC development.…”

Section: Studies In Otrmentioning

confidence: 99%

“…Only 5 studies informed about follow-up time of cSCC. Thirteen studies included patients with cSCC on the total body, [42][43][44][45][46][47][48][49][51][52][53]56,57 three studies reported on patients with a cSCC in the head and neck area. 50,54,55 Studies in the immunocompetent population…”

Section: Studies In Otrmentioning

confidence: 99%

Metastasis of cutaneous squamous cell carcinoma in organ transplant recipients and the immunocompetent population: is there a difference? a systematic review and meta‐analysis

Genders

Weijns

Dekkers

et al. 2019

Acad Dermatol Venereol

View full text Add to dashboard Cite

Background Organ transplant recipients (OTR) have a higher risk of developing cutaneous squamous cell carcinoma (cSCC) compared to the immunocompetent population. Immunosuppression is often stated as a risk factor for metastasis. However, evidence for this is scarce.Objectives To investigate the cSCC metastasis risk in OTR and the immunocompetent population by systematically reviewing the literature.Methods A systematic review of the literature was performed up to January 2018 using: Medline; Embase; Web of Science and ISI Science Citation Index. Studies assessing cSCC metastasis risk in ORT or immunocompetent cohorts were considered. A pooled risk estimate for metastasis was calculated for the immunocompetent population and OTR separately. ResultsThe pooled metastasis risk estimate for OTR was, respectively, 7.3% (95% CI 6.2-8.4) for cSCC on total body, and 11.0% (95% CI 7.7-14.8) for cSCC of the head neck area. For the immunocompetent population reported risk estimate analysis showed a pooled metastatic risk of 3.1% (95% CI 2.8-3.4) in total body cSCC and of 8.5% (95% CI 7.3-9.8) in cSCC of the head and neck area.Pooled risk estimate per single cSCC in OTR was 1.3% (95% CI 1.0-1.7) in total body cSCC and 4.0% (95% CI 2.7-5.5) in cSCC of the head and neck area. In the immunocompetent population, these pooled risk estimates were, respectively, 2.4% (95% CI 2.1-2.6) and 6.7% (95% CI 5.7-7.8).Conclusions Organ transplant recipients show a higher overall risk of cSCC metastasis compared to the immunocompetent population. Metastasis risks per single cSCC were substantially lower in both groups. However, due to heterogeneity and differences between studies, comparisons are difficult. Comprehensive follow-up studies with defined cohorts are necessary to adequately asses the risk for cSCC metastasis.

show abstract

“…Twenty-nine eligible studies comprising a total of 36,021 renal transplant recipients were included in the current meta-analysis [ Figure 1 ]. [ 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 ] Of the 29 publications, 25 were used for estimating the incidence of NMSC[ 14 15 16 17 18 19 20 21 22 23 25 26 27 28 29 30 33 34 35 36 37 38 39 40 41 42 ] whereas 11 publications were included to estimate the incidence of SCC and BCC. [ 14 15 18 19 22 27 32 34 38 40 42 ] Basic characteristics of included studies are presented in Table 1 .…”

Section: Resultsmentioning

confidence: 99%

“…Majority of included studies had been performed in Europe ( n = 19),[ 14 15 16 17 20 21 23 24 25 26 29 30 31 32 33 35 37 38 41 ] four in Australia and New Zealand,[ 18 19 28 34 ] three in Middle East,[ 36 40 42 ] and three in South Africa,[ 22 ] Brazil,[ 39 ] and Canada. [ 27 ] There were 16 retrospective cohort studies,[ 14 16 22 23 25 27 28 29 30 32 33 35 36 39 41 42 ] 12 prospective cohort studies. [ 17 18 19 20 21 24 26 31 34 37 38 40 ] The mean age at transplantation and follow-up period ranged from 37 to 52.2 and 1.5 to 27.75 years, respectively.…”

Section: Resultsmentioning

confidence: 99%

Incidence of nonmelanoma skin cancer in renal transplant recipients: A systematic review and meta-analysis

2018

View full text Add to dashboard Cite

Background:Nonmelanoma skin cancer (NMSC) in renal transplant recipients is common and associated with significant morbidity and mortality. The aim of the present systematic review and meta-analysis was to estimate the incidence of NMSC among renal transplant recipients.Materials and Methods:We systematically searched PubMed, Medline, Scopus, and Web of Science databases for studies that assessed the incidence of NMSC in renal transplant recipients using a combination of relevant keywords. Two independent investigators included studies and extracted necessary information. Random effect meta-analysis was used to estimate pooled incidence of NMSC with 95% confidence intervals (CIs).Results:Twenty-nine studies comprising 36,021 patients meet the criteria for the systematic review. The pooled incidence of NMSC in renal transplant recipients was 12.6% (95% CI: 12%–14%) with a majority of squamous cell carcinoma (SCC) 55% (95% CI: 47%–63%). The pooled estimate of the incidence rates of SCC and basal cell carcinoma was 2.7% (95% CI: 2%–3.4%) and 2.2% (95% CI: 1.5%–2.8%), respectively. Subgroup analysis per geographic location showed that pooled incidence of NMSC was 39.1% (95% CI: 26.3%–51.8%), 12.4% (95% CI: 8.8%–16%), and 1.2% (95% CI: 0.4%–2%) in Australia and New Zealand, Europe, and Middle East, respectively.Conclusion:The results of the current meta-analysis demonstrated that the incidence of NMSC in renal transplant recipients varies widely. Regarding the high incidence of NMSC among renal transplant recipients, awareness of associated risk factors and early diagnosis of the malignancy in the population is a major clinical need.

show abstract

Non-melanoma skin cancer in Portuguese kidney transplant recipients - incidence and risk factors

Cited by 17 publications

References 28 publications

Modifiable Risk-factors for Keratinocyte Cancers in Australia: A Case-control Study

Modifiable Risk-factors for Keratinocyte Cancers in Australia: A Case-control Study

Metastasis of cutaneous squamous cell carcinoma in organ transplant recipients and the immunocompetent population: is there a difference? a systematic review and meta‐analysis

Incidence of nonmelanoma skin cancer in renal transplant recipients: A systematic review and meta-analysis

Contact Info

Product

Resources

About