Pretibial mucinosis in an euthyroid patient

Milman, Laura de Mattos; Grill, Aline Barcellos; Müller, Giana Paula; Villa, Damiê De; Souza, Paulo Ricardo Martins

doi:10.1590/abd1806-4841.20164043

Cited by 7 publications

(3 citation statements)

References 11 publications

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“…The pathogenesis of this rare condition has not been fully elucidated and, to the best of our knowledge, 22 cases have been reported in the English literature and are summarized in Table 1[1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11]. Lymphatic stasis, stimulated by the obesity, seems to determine a local hypoxia leading to the accumulation of mucin [4].…”

Section: Report Of Casesmentioning

confidence: 99%

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Obesity-Associated Lymphedematous Mucinosis: Two Further Cases and Review of the Literature

et al. 2018

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Cutaneous mucinoses are a group of conditions characterized by increased amounts of acid mucin in the dermis. They can be generalized or localized and occur isolated or in the setting of systemic diseases. Obesity-associated lymphedematous mucinosis is a distinct variant of mucinosis occurring in obese patients without any thyroid dysfunction. So far, only few cases of this rare condition have been reported in the English literature. Here, we describe two new cases and discuss some histological differences with the pretibial myxedema.

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Section: Report Of Casesmentioning

confidence: 99%

“…Lymphatic stasis, stimulated by the obesity, seems to determine a local hypoxia leading to the accumulation of mucin [4]. This appears to be induced by the deposition in the interstice of plasmatic proteins due to a defect of the lymphatic drainage and the ischemia favored by a frequently associated venous insufficiency.…”

Section: Report Of Casesmentioning

confidence: 99%

Obesity-Associated Lymphedematous Mucinosis: Two Further Cases and Review of the Literature

et al. 2018

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“…In 1993 Somach et al 2 described pretibial mucin deposition in euthyroid patients with associated features of stasis dermatitis. Additional cases of euthyroid pretibial mucinosis associated with chronic venous insufficiency, lymphedema, and trauma 3 have been since found. Subsequently, increased mucin deposition has been described in obese patients with lymphedema of the legs.…”

Section: Obesity-associated Cutaneous Mucinosis and Pretibial Stasis ...mentioning

confidence: 99%

New and emerging conditions of acquired cutaneous mucinoses in adults

Rongioletti

2022

Acad Dermatol Venereol

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Cutaneous mucinoses are a heterogenous group of conditions, characterized by the deposition of glycosaminoglycans (mucin) in the dermis, follicles, or in the epidermis. Major cutaneous mucinoses include lichen myxedematosus, scleredema, mucinoses associated with thyroid disease, reticular erythematous mucinosis, papulonodular mucinosis associated with connective tissue diseases, and cutaneous focal mucinosis. The aim of this review is to provide an update of what has currently been reported in the last 30‐year literature about several new or emerging conditions of acquired cutaneous mucinoses in adults. Two new clinico‐pathologic entities have been described: (i) Obesity‐associated lymphedematous mucinosis and pretibial stasis mucinosis; (OACM) (ii) Nodular mucinosis of the breast (NMB). Two relatively new disease categories encompassing cutaneous mucinoses with a common pathogenetic mechanism have been identified: (i) Cutaneous mucinoses associated with drug exposure including biologic therapy, anti–colony‐stimulating factor 1 receptor (CSF1R) and subcutaneous intralesional interferons (toxic dermal mucinoses); (ii) Cutaneous mucinosis following physical agents including mechanical traumas and after knee replacement.

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