Cutaneous metastases from gastric adenocarcinoma 15 years after curative gastrectomy

Liu, Fang; Yan, Wen Liang; Zhang, Min; Sang, Hong

doi:10.1590/abd1806-4841.20153829

Cited by 10 publications

(8 citation statements)

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“…The morbidity of gastric cancer has increased with economic development and changes in dietary patterns[19-22]. Furthermore, Helicobacter pylori infection, gastric polyps, and gastritis can lead to gastric cancer[23-27].…”

Section: Discussionmentioning

confidence: 99%

ANGPTL2 expression in gastric cancer tissues and cells and its biological behavior

Sheng¹,

Chen²,

Tu³

et al. 2016

WJG

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AIMTo explore expression of angiopoietin-like protein 2 (ANGPTL2) and its effect on biological behavior such as proliferation and invasiveness in gastric cancer.METHODSWestern blotting was used to detect expression of ANGPTL2 in 60 human normal gastric tissues, 60 human gastric cancer tissues and gastric cell lines including GES-1, N87, SGC7901, BGC823 and PAMC82. 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) and Transwell assay were used to detect the proliferation and invasive ability of gastric cancer cells.RESULTSCompared to normal tissues, ANGPTL2 protein levels were significantly upregulated in gastric tissues, and this level was closely correlated with gastric tumor grade, clinical stage and lymph node metastasis. Compared to GES-1 cells, ANGPTL2 mRNA and protein levels were significantly increased in gastric cancer cells including N87, SGC7901, BGC823 and PAMC82. The expression of ANGPTL2 in highly malignant gastric cancer cell lines BGC823 and PAMC82 was significantly higher than in low malignancy gastric cancer cell lines N87 and SGC7901. MTT and Transwell experiments indicated that the proliferation rate and invasive ability of stable overexpressed gastric cancer cells was faster than in cells transfected with Lv-NC and blank control cells, and the invasive ability of stable overexpressed gastric cancer cells was higher than that of cells transfected with Lv-NC and blank control cells.CONCLUSIONANGPTL2 contributed to proliferation and invasion of gastric cancer cells. In clinical treatment, ANGPTL2 may become a new target for treatment of gastric cancer.

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Section: Discussionmentioning

confidence: 99%

ANGPTL2 expression in gastric cancer tissues and cells and its biological behavior

Sheng¹,

Chen²,

Tu³

et al. 2016

WJG

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“…Metastasisfrom gastric adenocarcinoma usually develop on the abdominal wall as skin nodules or Sister Mary Joseph's nodules around the umbilicus (Figure 3). 4,5 However, in this case, the skin metastasis did not manifest as nodules but as skin papules, which initially appeared as dermatitis in general. Thus, the patient was prescribed with dermal cream treatment.…”

Section: Discussionmentioning

confidence: 62%

Unusual Skin Metastasis from Gastric Cancer: A Case Report

Budipramana

2020

BIKK

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Background: Skin metastasis from gastric cancer are relatively rare, but they have important clinical significance because they usually indicate a worse prognosis. Skin metastasis from gastric cancer may spread through lymphatic ducts, blood vessels in the ligamentum teres, contiguous extension, or embryologic remnants of the umbilicus. Purpose: To report an unusual skin metastasis from gastric cancer that clinically resembles as a benign lesion of skin papules. Case: A rare metastasis from gastric cancer origin in a 61-year-old male in the abdominal skin. Gastric cancer metastasis in an unusual site such as the abdominal skin often resembles as dermatitis, especially in the early course of metastatic spreading, which looked like common papules on the skin. Discussion: In the beginning, the skin papules were not suspected to be a metastatic process because there was no palpable or no tenderness in the subcutan or fascia underneath. The appearance resembled common dermatitis. However, as papules rapidly spread to the surrounding skin, the malignancy was then suspected. The incisional biopsy from the papules was performed and showed that it was metastatic diffuse-type gastric adenocarcinoma. Conclusion: The skin metastasis was different from general nodules, but rather as skin papules of general dermatitis in initial appearance. The surgeon and dermatologist should be alert if they find any benign appearance of a skin lesion on the abdominal wall in a patient with a history of gastric cancer surgery.

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“…The most common site of skin metastasis is the abdominal wall where it is known as Sister Mary Joseph nodule, with less reported sites being scalp, eyelids, fingertips, neck and trunk. 4 They usually present as erythematous or violaceous lesions which are most commonly painless nodules. 4 Less reported types are erysipelas or cellulitis like lesions, lesions with zosteriform pattern, scarred lesions, plaques, epidermoid cyst, wart-like lesions and even non-specific dermatitis.…”

Section: Discussionmentioning

confidence: 99%

“…4 They usually present as erythematous or violaceous lesions which are most commonly painless nodules. 4 Less reported types are erysipelas or cellulitis like lesions, lesions with zosteriform pattern, scarred lesions, plaques, epidermoid cyst, wart-like lesions and even non-specific dermatitis. 2 Our patient had a unique patterned cauliflower-like proliferative central part which was surrounded by a smooth erythematous ring.…”

Section: Discussionmentioning

confidence: 99%