Granuloma faciale: a good therapeutic response with the use of topical tacrolimus

Lima, Raquel Sucupira Andrade; Maquiné, Gustavo Ávila; Silva, Renato Cândido da; Schettini, Antônio Pedro Mendes; Santos, Mónica

doi:10.1590/abd1806-4841.20153339

Cited by 3 publications

(2 citation statements)

References 9 publications

(7 reference statements)

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“…The specificity of the disease in terms of its refraction to treatment constitutes a challenge for doctors and causes a psychological problem for the patient. However, more recent studies have shown good results after four months with topical tacrolimus 0.1% [10]. Meanwhile, other studies have shown good and promising results with intralesional rituximab [11].…”

Section: Discussionmentioning

confidence: 99%

Unusual keloidal granuloma faciale recalcitrant to several treatments

Soufi¹,

Fawal²,

Alshehabi³

2022

Our Dermatol Online

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Granuloma faciale is a rare chronic skin disorder characterized by asymptomatic papules, nodules, and plaques on the face. Although its pathogenesis is unknown, researchers have suggested that one of the main causative factors may be sun exposure, as lesions are aggravated by sunlight and favor light-exposed areas. Herein, we are reporting the case of an adult female patient with keloidal granuloma faciale treated with a combination of several treatment methods with no improvement and a relapse. In this case, we attempted to highlight the difficulties that the doctor faces in treating the disease and to share the medical literature of our treatment experience.

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Section: Discussionmentioning

confidence: 99%

Unusual keloidal granuloma faciale recalcitrant to several treatments

Soufi¹,

Fawal²,

Alshehabi³

2022

Our Dermatol Online

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“…Possible adverse effects of this treatment have been described, such as residual hyperchromia and telangiectasias [8].…”

Section: Discussionmentioning

confidence: 99%

Granuloma faciale treatment with tacrolimus

Santos-Alarcón

Sanchis-Sánchez²,

Ferrando-Roca³

et al. 2016

DOJ

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We present a 40-year-old woman with a one-year history of a solitary and asymptomatic facial lesion. On physical examination a slightly infiltrated, smooth red to brown nodule was seen at the left malar region. A biopsy established the diagnosis of granuloma faciale. After two-months therapy with topical tacrolimus 0,1%, nodule was resolved. Case synopsisA 40-year-old woman presented with a one-year history of a solitary and asymptomatic facial lesion. On physical examination a slightly infiltrated, red to brown nodule was seen at the left malar region (Figure 1). The borders of the nodule were well defined; it had a smooth surface with dilated follicular ostia. The patient's medical history was unremarkable. Figure 1. Slightly infiltrated, red to brown nodule at left malar region.Histopathologic examination demonstrated, a dense, polymorphous, inflammatory cell infiltrate in the mid and deep dermis. The epidermis was spared and a Grenz zone in the upper dermis was present (Figure 2).

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