Persistent docetaxel-induced supravenous erythematous eruption

Abstract

Taxanes are drugs used to treat many types of cancer, including breast and lung cancer. The most common side effects of these drugs are neutropenia and mucositis. Signs of skin toxicity are observed in about 65% of cases and include alopecia, hypersensitivity reactions, persistent supravenous erythematous eruption, nail changes, scleroderma reactions and others. We report two cases of skin reaction to docetaxel and warn that it is not necessary to interrupt the treatment in these cases.

Docetaxel-Induced Supravenous Serpentine Dermatitis: A Case Report

“…Supra-venous serpentine dermatitis is a rare cutaneous adverse reaction to irritant medications or chemicals that are infused intravenously. Few case reports are available in the literature of similar phenomena caused by chemotherapeutic agents such as carboplatin, vinorelbine [5], docetaxel [6][7][8][9] and anti-tumour necrosis factor-alpha [10]. Lesions are described as erythematous macules or purpuric papules that typically develop 24 hours to 15 days after exposure.…”

“…Cutaneous reactions are particularly common [4]. We describe a case of docetaxel-induced supra-venous serpentine dermatitis, which is a potentially alarming interface dermatitis with few case reports in the literature [5][6][7][8][9][10][11].…”

Assessment of a Nano-Docetaxel Combined Treatment for Head and Neck Cancer

“…This mechanism limits cell growth in the locoregional area of the tumor. However, DTX is associated with adverse effects that may be severe or dose-limiting, including febrile neutropenia, neuropathy, and alopecia [10][11][12][13][14][15][16][17]. Better patient outcomes may be achieved with lower DTX doses that would result in fewer severe side effects.…”

“…Onco 2021, 1, FOR PEER REVIEW 2 neutropenia, neuropathy, and alopecia [10][11][12][13][14][15][16][17]. Better patient outcomes may be achieved with lower DTX doses that would result in fewer severe side effects.…”