Cutaneous metastasis from gastrointestinal adenocarcinoma of unknown primary origin

Junqueira, Ana Lucia; Corbett, Ana Maria França; Filho, Jayme de Oliveira; Nasser, Kassila da Rosa; Haddad, Natalie; Tebet, Ana Carolina Franco

doi:10.1590/abd1806-4841.20153175

Cited by 7 publications

(4 citation statements)

References 6 publications

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“…Extramammary Paget's disease usually occurs in the age group of 60-80 years old with the highest incidence at the age of 65 years. The current case fits the age profile similar to other reported publications of cutaneous metastatic adenocarcinoma of unknown primary [2].…”

Section: Discussionsupporting

confidence: 90%

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Paget's disease of the penis and scrotum mimicking cutaneous metastatic lesion from gastrointestinal or genitourinary tract adenocarcinoma

et al. 2020

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Section: Discussionsupporting

confidence: 90%

“…Patients can be completely asymptomatic or may have pruritus, pain or burning [1]. When the perineum lesion is associated with nodular growth, it may mimic cutaneous metastasis from adenocarcinoma of the genitourinary tract or gastrointestinal system [2]. This difficult clinical differentiation was observed in this current case.…”

Section: Case Presentationmentioning

confidence: 73%

Paget's disease of the penis and scrotum mimicking cutaneous metastatic lesion from gastrointestinal or genitourinary tract adenocarcinoma

et al. 2020

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“…Cutaneous metastases are rare, occurring in 0.7%–9% of patients with cancer 1. They usually signal advanced internal malignancy but can be difficult to recognise given their clinical variability 2.…”

Section: Descriptionmentioning

confidence: 99%

Multiple cutaneous metastases as the first sign of metastatic carcinoma of unknown primary

et al. 2018

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DesCripTionAn elderly man with a background of bladder cancer in remission, monoclonal gammopathy of uncertain significance and chronic obstructive pulmonary disease was referred by his general practitioner to the dermatology clinic with enlarging, non-tender cutaneous nodules on his neck, upper back and scalp. The first of these had been noted above the left clavicle 3 months previously during a hospital admission, and had since rapidly increased in size, together with a more recent development of newer 'bumps' on the scalp.On physical examination there was a 25×20 mm cutaneous nodule sited above his left clavicle ( figure 1A). This nodule was firm but not hard, oval-shaped, mobile, had prominent visible vasculature and no associated surface epidermal change. In addition, there were three similar lesions sited adjacent to each other on the vertex of his scalp, and one macular lesion on his upper back (figure 1B). The diagnosis of multiple cutaneous metastases was suspected, with the differential diagnoses including cutaneous lymphoma. Rapid access imaging and 4 mm cutaneous punch biopsy were performed.CT of the head, neck, chest, abdomen and pelvis without contrast, due to iodine allergy, demonstrated a cavitating left upper lobe lung lesion and probable brain metastases, but no definitive primary site (figure 2). A subsequent MRI of the head confirmed the presence of multiple enhancing lesions consistent with metastases ( figure 3A,B).Histological analysis of the scalp nodule confirmed the presence of metastatic carcinoma, with basaloid features and non-specific immunohistochemistry favouring urothelial or hepatobiliary primary. Following discussion at lung multidisciplinary team meeting, it was concluded the cavitating lung lesion may represent an aspergilloma, and therefore the diagnosis should be metastatic carcinoma of unknown primary. The patient was referred to the oncology service, who explained to the patient his disease was inoperable and incurable, irrespective of the primary site. Furthermore, the risks and toxicities of palliative chemotherapy were thought to outweigh the benefits of treating his advanced disease. He accepted palliative radiotherapy for the now-symptomatic left-sided neck mass and unfortunately passed away 4 months following diagnosis. Cutaneous metastases are rare, occurring in 0.7%-9% of patients with cancer.

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“…[ 1 ] The incidence of cutaneous metastases varies from 0.7% to 9% of all cases of malignant disease. [ 2 ] They are the result of direct invasion or local or distant spread of a primary malignancy. [ 3 ]…”

mentioning

confidence: 99%

Esophageal adenocarcinoma with metastatic skin nodules and Budd–Chiari syndrome

Singh

Bansal

Arora

et al. 2021

Journal of Postgraduate Medicine

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Cutaneous metastasis from gastrointestinal adenocarcinoma of unknown primary origin

Cited by 7 publications

References 6 publications

Paget's disease of the penis and scrotum mimicking cutaneous metastatic lesion from gastrointestinal or genitourinary tract adenocarcinoma

Paget's disease of the penis and scrotum mimicking cutaneous metastatic lesion from gastrointestinal or genitourinary tract adenocarcinoma

Multiple cutaneous metastases as the first sign of metastatic carcinoma of unknown primary

Esophageal adenocarcinoma with metastatic skin nodules and Budd–Chiari syndrome

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