Musculoskeletal and cutaneous sarcoidosis: exuberant case report

Abstract

Sarcoidosis is a multisystem granulomatous disease of unknown cause. The osteoarticular involvement in sarcoidosis is rare and is often associated with cutaneous and long-standing chronic multisystem disease. More common in black women, osseous sarcoidosis is difficult to diagnose, with an incidence of 3 to 13%. The most characteristic radiological clinical picture evidences rounded, well-defined cysts, with no periosteal reaction and without peripheral sclerosis. The small bones of hands and feet are the most frequently involved sites. This report aims to demonstrate a rare case of osteoarticular sarcoidosis with characteristic clinical presentation, and highlight the importance of detecting osteoarticular involvement in this pathology.

Unmasking of Sarcoidosis After Successful Management of Cushing's Syndrome

“…Arthralgias may be the first manifestation of the disease or may be a part of Lofgren’s syndrome (which comprises hilar adenopathy, acute polyarthritis, and erythema nodosum). Usually, the joint symptoms are symmetric and oligoarticular [ 4 ].…”

An Unusual Orthopaedic Disease: Sarcoidosis—A Case Report

“…Radiologically, it may manifest as cystic or osteolytic lesions or as cortical defects and reticularizations of cortical bones as well as sclerotic and destructive lesions or similar to periostitis. 1,11 Bone involvement in sarcoidosis may even cause destructive lesions resulting in pathological fractures. 8 In MRI, T1 sequences show decreased nonspecific signal intensities, while T2 sequences show increased nonspecific signal intensities.…”

“…It is more common in individuals younger than the age of 50 years with a slight predominance in females. 1 While involvements of lungs, respiratory system, and skin are more common, multiple involvement of lymph nodes, salivary glands, eyes, musculoskeletal system may also be seen. The pathophysiology of the disease is not exactly discovered and the diagnosis is made after pathologic investigations.…”

“…2 Bone involvement of sarcoidosis is generally asymptomatic and its frequency ranges from 3 to 13%. 1,3 Bone involvement may be lytic, sclerotic, or mixed type. 4 Radiologic findings include the appearance of well-demarcated cysts without any periosteal reaction and no peripheral sclerosis.…”

“…4 Radiologic findings include the appearance of well-demarcated cysts without any periosteal reaction and no peripheral sclerosis. 1 The disease involves mostly phalanges in the skeletal system, forming dactylitis. The involvement may also be present in maxilla, skull, facial bones, vertebrae, ribs, and pelvic bones 5 ; however, infrequent involvement of other bones, especially long ones might be encountered as in the case presented here.…”