Case for diagnosis

Abstract

Cutaneous involvement associated to multiple myeloma varies from 5 to 10% of cases and is infrequently recognized. Cutaneous metastatic plasmacitomas are rare. We present the case of a 72-year-old man with multiple myeloma in complete remission since 2 years ago with cutaneous tumors on the trunk and face. A cutaneous biopsy was consistent with plasmacytoma. The patient was treated with melphalan, prednisolone and radiotherapy. Despite optimal therapeutic response of the lesions, the disease progressed, with the appearance of new extra-cutaneous plasmocytomas. The cutaneous metastatic plasmocytomas were the first sign of progression of the disease.

Cutaneous Plasmacytoma: A Case Report

“…Histopathological findings are characterised by monomorphic dermal and subcutaneous infiltrates of plasma cells. Immunohistochemically we see monoclonality of the plasma cells which have strong immunoexpression for CD138 (6).…”

Cutaneous Lesions of Multiple Myeloma of the Lower Extremity Masquerading as Squamous Cell Carcinoma

“…Immunohistochemical studies show CD138, CD79a, and epithelial membrane antigen expression in the neoplastic cells [2,4]. All major immunoglobulin classes, except for IgE, have been reported in cutaneous MM [4,5] with IgG being the most common subtype associated with cutaneous lesions [2,[6][7].…”

Cutaneous Plasmacytoma: Metastasis of Multiple Myeloma at the Fracture Site

“…Primary cutaneous extramedullary plasmacytoma is when plasma cells infiltrate skin without the involvement of bone marrow. Secondary cutaneous extramedullary plasmacytoma can occur from metastasis from MM or from primary extramedullary plasmacytoma of other tissues 11 12 . In our case, the patient had secondary cutaneous extramedullary plasmacytoma which occurred from direct spreading of MM at the surgical repair site.…”

“…Four out of seven patients in these cases died from rapid progression of the disease. Concurrent chemoradiation therapy is considered a treatment of choice in patients with extensive involvement 7 10 12 13 . We herein report an interesting case of cutaneous plasmacytoma at the surgical site of fracture repair.…”