Optic neuritis due to immunobiologics: first Brazilian case report

Abstract

The change in immunological response obtained by immunobiologics has brought a new paradigm to the treatment of immune-mediated disorders. As a result of their efficacy, there is a positive impact on the quality of life of patients. However, severe side effects, such as demyelination of cerebral or peripheral nerves, have been reported. After review of literature using PubMed and MEDLINE data from 2000 to 2012, we identified the cases correlating the biological uniterms and optic neuritis. This article reports the first Brazilian optic neuritis case associated with the use of immunobiologics. This publication is justified by the rarity of the disease and atypical therapeutical evolution.

Development of paradoxical inflammatory disorders during treatment of psoriasis with TNF inhibitors: a review of published cases

“…70 Optic neuritis was seen in three case reports following treatment with infliximab or adalimumab. 67,71,72 diagnosed 12 months after initiation of adalimumab, at a screening for tuberculosis, which showed concomitant TB. As a lung biopsy was negative for acid-fast bacilli and cultures negative for mycobacteria and fungi, a diagnosis of sarcoidosis was made.…”