Do you know this syndrome?

Santos, Guida; Lestre, Sara; João, Alexandre

doi:10.1590/abd1806-4841.20132266

Cited by 6 publications

(3 citation statements)

References 5 publications

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“…Male patients tended to have erectile dysfunction and gynecomastia [ 21 ], while amenorrhea usually presented in female patients. Hyperprolactinemia was present in approximately one-quarter of patients.…”

Section: Discussionmentioning

confidence: 99%

Endocrine Manifestations in POEMS Syndrome: a case report and literature review

Huang

et al. 2019

BMC Endocr Disord

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BackgroundPOEMS syndrome, a rare systemic disease, is characterized by 5 components: Peripheral neuropathy, Organomegaly, Endocrinopathy, M protein elevation, and Skin changes. It usually presents with multiplex endocrine manifestations and is easily misdiagnosed and incorrectly treated.Case presentationWe report herein a case of POEMS syndrome that initially presented as hyperpigmentation and severe pitting edema of the lower extremities. Throughout the patient’s multiple hospitalizations for more than one year, he was treated erroneously for Addison’s disease and primary hypothyroidism due to the presence of limb numbness and weight loss. In addition, he was misdiagnosed with diabetic peripheral neuropathy due to a history of type 2 diabetes mellitus.ConclusionEndocrinopathy is a critical feature of POEMS syndrome but its mechanisms are still poorly understood. The most common endocrine abnormality is hypogonadism, and the second is adrenal insufficiency, followed by hypothyroidism and subclinical hypothyroidism, then diabetes or glucose intolerance. In cases of the coexistence of endocrinopathy and unexplained peripheral neuropathy, especially in multisystem disorders, POEMS syndrome should be considered. Endocrine evaluation including thyrotropin, free thyroxine, fasting glucose, gonadal hormones, prolactin, cortisol, ACTH, and calcium should be assessed. The purpose of the current report was to provide increased awareness of POEMS syndrome.

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Section: Discussionmentioning

confidence: 99%

Endocrine Manifestations in POEMS Syndrome: a case report and literature review

Huang

et al. 2019

BMC Endocr Disord

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“…Male patients tend to develop erectile dysfunction and gynecomastia, whereas female patients develop amenorrhea and galactorrhea. 16 Some researchers have suggested that accelerated conversion of androgens into estrogens in patients with POEMS syndrome increases the level of serum estrogens. Increased estrogen can potentially cause hyperprolactinemia either directly or by modifying the estrogen-testosterone ratio.…”

Section: Discussionmentioning

confidence: 99%

Missed diagnosis of POEMS syndrome with onset of progressive fatigue and numbness: a case report

et al. 2021

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POEMS syndrome is a rare multisystem disease associated with an underlying plasma cell disorder. Its name is an acronym for peripheral neuropathy (P), endocrinopathy (E), organomegaly (O), monoclonal plasma cell proliferative disorder (M), and skin changes (S). This case report describes a patient with POEMS syndrome who presented with progressive fatigue and numbness in the lower extremities. Initially, the patient was erroneously diagnosed with diabetes and diabetic peripheral neuropathy because of the endocrinopathy associated with POEMS syndrome. After a second hospitalization, the patient was diagnosed with POEMS syndrome and recovered with alkylator therapy and a peripheral blood stem cell transplant. The patient’s overall condition was improved at the 1-year follow-up. POEMS syndrome should be considered if a patient presents with endocrinopathy and unexplained peripheral neuropathy.

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“…В описанных в литературе клинических случаях в дебюте POEMS-синдрома чаще всего встречались у мужчин эректильная дисфункция и гинекомастия [6], гиперпролактинемия примерно у 1/4 пациентов. В приведенном клиническом случае эндокринологические проявления POEMS-синдрома либо слабо выражены (субклинический гипотиреоз), либо рассматривались изолированно (гинекомастия), поэтому первоначально не отмечены как симптомы одного заболевания.…”

Section: îáñóAeäåíèåunclassified

POEMS-syndrome: diagnostic difficulties

Lebedev

Paranina

Rossiyev

et al. 2020

Terapevticheskii arkhiv

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POEMS syndrome is a rare paraneoplastic syndrome whose name is an acronym formed from the initial letters of the names of the symptoms originally used to determine it: polyneuropathy, organomegaly, endocrinopathy, monoclonal protein and skin changes. Due to the rarity of the disease and the small number of cases described in the literature, its diagnosis is difficult. The average time from onset of symptoms to diagnosis is 18 months. Moreover, the prognosis of the disease depends on the early onset of specific treatment. The article describes a clinical case of POEMS-syndrome in a 53-year-old man, which illustrates the difficulties associated with the timely recognition of this unusual disease.

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Do you know this syndrome?

Cited by 6 publications

References 5 publications

Endocrine Manifestations in POEMS Syndrome: a case report and literature review

Endocrine Manifestations in POEMS Syndrome: a case report and literature review

Missed diagnosis of POEMS syndrome with onset of progressive fatigue and numbness: a case report

POEMS-syndrome: diagnostic difficulties

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