Atrophic dermatofibroma

Mota, Amanda Nascimento Cavalleiro de Macedo; Tortelly, Violeta Duarte; Obadia, Daniel Lago; Silva, Roberto Souto da

doi:10.1590/abd1806-4841.20132234

Cited by 12 publications

(20 citation statements)

References 10 publications

(14 reference statements)

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“…Dermatofibromas are common, usually benign, soft-tissue tumors often found on the extremities, particularly the lower limbs. They typically present as asymptomatic, firm, slow-growing, red-brown, or yellow-brown dome-shaped nodules, measuring between a few millimeters to 1 to 2 cm in diameter [2]. In the current case, the tumor measured 12 cm × 6 cm, which was large compared to a typical dermatofibroma.…”

Section: Discussionmentioning

confidence: 81%

“…They are most frequently found in the extremities and are more common in women [1]. They usually present as red-brown or yellow-brown papules on the limbs, particularly in the thighs and lower legs, measuring less than 2 cm in diameter [2]. The tumor is typically located in the skin, involving the subcutaneous fat, dermis, and epidermis, without invasion to surrounding muscles.…”

Section: Introductionmentioning

confidence: 99%

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Giant Muscle Invasive Dermatofibroma Clinically Mimicking a Malignant Tumor

Kinoshita

Ishii

Kamoda

et al. 2019

Case Reports in Dermatological Medicine

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Dermatofibromas are common benign fibrohistiocytic lesions, usually appearing as slow growing firm dermal nodules with a predilection for the extremities (mostly the lower legs). They are found mostly in middle-aged women and are usually smaller than 2 cm in diameter. Giant dermatofibromas exceeding 5 cm in diameter are rare. In recent years, reports have suggested a relationship between the primary size of dermatofibromas and rates of local recurrence and metastases after surgery. This relationship is however debated. The present report describes the case of a giant muscle invasive tumor in a 51-year-old female patient who presented with a large ulcerated mass in the right upper arm. The tumor appeared clinically malignant, measuring approximately 12 cm × 6 cm in size, with ulceration and invasion of surrounding muscle. Wide resection of the tumor was performed with myocutaneous flap-plasty. Histopathological examination showed evidence of a dermatofibroma. No recurrence, metastases, or other complications were noted at 5 years after surgery. The present case demonstrates that although dermatofibromas are essentially benign, they may present with atypical features including large size, ulceration, and muscle invasion, clinically mimicking malignant tumors.

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Section: Discussionmentioning

confidence: 81%

Section: Introductionmentioning

confidence: 99%

Giant Muscle Invasive Dermatofibroma Clinically Mimicking a Malignant Tumor

Kinoshita

Ishii

Kamoda

et al. 2019

Case Reports in Dermatological Medicine

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“…Atrophic dermatofibromas have been observed worldwide; indeed, publications describing individuals with this lesion have originated from Argentina [15], Austria [9], Brazil [26], Canada [16], Cuba [14], France [12, 13], Germany [7], India [28], Italy [23], Japan [17, 18], Korea [20, 25], Mexico [11, 21], Portugal [27], Spain [8, 19], Turkey [22] and the United States [10, 24, 29, 30]. Most of the articles (14 of 24, 58%) on atrophic dermatofibromas describe one individual [10, 12, 13, 17–22, 24, 26, 28–30]; including our paper, two or three patients are reported in six manuscripts (25%) [8, 15, 16, 25, 27]. There are only four larger series (17% of the publications on atrophic dermatofibromas) which range from 15 to 26 patients [7, 9, 11, 23].…”

Section: Discussionmentioning

confidence: 99%

Atrophic Dermatofibroma: A Comprehensive Literature Review

Cohen

Erickson

Calame

2019

Dermatol Ther (Heidelb)

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Introduction An atrophic dermatofibroma is a benign fibrohistiocytic neoplasm. It typically presents as an asymptomatic patch with a depressed central area. Methods The PubMed database was used to search the following words: atrophic, dermatofibroma, elastic and fibers. The relevant papers and their references generated by the search were reviewed. Images of the clinical and pathological features of two patients with an atrophic dermatofibroma are presented. In addition, a comprehensive review of the characteristics of this unique dermatofibroma is provided. Results An atrophic dermatofibroma has been reported in 102 patients: 53 women, 11 men and 38 individuals whose gender was not provided. It typically appeared as an asymptomatic solitary patch with a central umbilication—most commonly on the shoulder or lower extremity or back—of women aged 48 years or older. Dermoscopy typically showed white scar-like patches; a patchy pigment network was also noted in some lesions. The pathology of an atrophic dermatofibroma has the same features that can be observed in a common fibrous dermatofibroma; there is acanthosis, basal layer hyperpigmentation, and induction of basal cell carcinoma-like features, hair follicle formation or sebaceous hyperplasia in the epidermis and a proliferation of spindle-shaped fibroblasts in the dermis. However, atrophic dermatofibromas also demonstrate depression of the central surface and thinning of the dermis; in many cases, the dermal atrophy is at least 50%. Elastic fibers are either decreased or absent. Similar to non-atrophic dermatofibromas, the immunoperoxidase profile of atrophic dermatofibromas is factor XIIIa-positive and cluster of differentiation 34 (CD34)-negative. The pathogenesis of atrophic dermatofibromas remains to be established. Conclusion An atrophic dermatofibroma is an uncommon benign variant of a dermatofibroma. The diagnosis can be suspected based on clinical features and dermatoscopic findings. A biopsy of the lesion will confirm the diagnosis. Periodic evaluation of the lesion site is a reasonable approach to the management of the residual tumor.

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“…Dermatofibromas are benign dermal neoplasms that are represented clinically by a papule, a plaque or a nodule with or without pigment, measuring up to 2 cm in diameter [ 1 ]. Out of the various subtypes of dermatofibromas, the atrophic and aneurismatic variant represents 2% of the total [ 2 , 3 ]. These rare occurring lesions seldom coexist, so features of both subtypes can be observed [ 4 ].…”

Section: Discussionmentioning

confidence: 99%

“…Dermoscopic classification of dermatofibromas considers them within the non-melanocytic lesions. Classical dermoscopic features describe the presence of a central white patch, with a peripheral fine reticular pigmented network [ 2 ]. Regarding these unlikely variants, atrophic dermatofibroma shows the presence of multiple, small scar-like areas and pigmented network in a patchy distribution [ 4 , 5 ].…”

Section: Discussionmentioning

confidence: 99%

An Atrophic Plaque with Arborizing Vessels

Villarreal‐Martínez¹,

Chávez‐Álvarez²,

Herz‐Ruelas³

et al. 2016

Case Rep Dermatol

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Dermatofibromas are a common finding in the daily clinical practice. Most lesions are found incidentally or because patients seek medical attention due to the aspect of the lesion. Rare variants of dermatofibroma such as aneurismatic or atrophic dermatofibroma can be encountered simultaneously; thus, these combined features may raise the possibility of other diagnoses to be considered. By providing diverse clinical and dermoscopic examples of dermatofibromas, we may prevent misdiagnosing these lesions. This case illustrates how two rare variants of dermatofibroma can coexist. Clinical presentation of dermatofibromas may vary greatly, and it is essential for dermatologists to recognize them clinically and dermoscopically before obtaining histopathological diagnosis.

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Atrophic dermatofibroma

Cited by 12 publications

References 10 publications

Giant Muscle Invasive Dermatofibroma Clinically Mimicking a Malignant Tumor

Giant Muscle Invasive Dermatofibroma Clinically Mimicking a Malignant Tumor

Atrophic Dermatofibroma: A Comprehensive Literature Review

An Atrophic Plaque with Arborizing Vessels

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