Ectopic cutaneous Schistosomiasis

Vargas, Thiago Jeunon de Sousa; Lopes, Raquel Ferreira; Moraes, Maria de Lourdes Palermo F. N.; Azevedo, Karen Grace Pena de; Sousa, Maria Auxiliadora Jeunon

doi:10.1590/abd1806-4841.20132105

Cited by 5 publications

(2 citation statements)

References 2 publications

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“…However, schistosome eggs can sometimes be deposited in places besides organs associated with the hepatic portal vein where they can cause serious ectopic lesions (e.g. ectopic schistosomiasis mansoni in the dermis [ 1 , 2 ], the nervous system [ 3 , 4 ], or the reproductive system [ 5 – 7 ]. To date, little is known about the deposition of eggs in the spleen.…”

Section: Introductionmentioning

confidence: 99%

The formation of egg granulomas in the spleens of mice with late Schistosoma japonicum infection alters splenic morphology

et al. 2015

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BackgroundSplenomegaly is a characteristic symptom of schistosome infection. Unlike the well known hepatic pathology of schistosomiasis, splenomegaly has received little scientific research and is generally considered to be a non-specific congestion caused by increased blood pressure within the venous sinuses. Moreover, to date, few studies have reported the deposition of schistosome eggs in the spleen. In a previous study, however, we observed that prolonged S. japonicum infections destroyed the structure of the lymphoid follicles in the spleen of mice at 8 weeks post-infection and found that eggs were frequently deposited in the spleen. These prior observations suggested a relationship between granulomas and splenic morphology which we investigate further in this study.MethodsC57BL/6 mice were infected percutaneously with twenty cercariae of S. japonicum and sacrificed at different times post-infection. The number of eggs present in the homogenates of spleens and livers was quantified by light microscopy. Splenic pathology was observed by immunohistochemistry staining of paraffin-embedded sections. At 18 weeks post-infection the infected mice were divided into two groups (granulomatous spleens and non-granulomatous spleens). Serum antibodies and cytokines in the antigen- or mitogen-stimulated lymphocyte cultures were then determined by ELISA.ResultsWe found that eggs deposition in the spleens of infected mice occurred frequently but only occasionally led to granulomas formation. The lymphoid follicles within the granulomatous spleens maintained their structural integrity until 20 weeks post-infection, unlike the lymphoid follicles in spleens without egg granulomas. Mice with granulomatous spleens accompanied by lymphoid follicles exhibited a germinal center (GC)-like structure and had enhanced humoral immune responses. Splenocytes from granulomatous spleens also showed significantly elevated levels of Th2 cytokines during late infection stages.ConclusionsOur results highlight that lymphoid follicles, which are not completely destroyed or are re-established in the spleen, can change the local immune environment and lead to changes in the splenic morphology of mice with chronic schistosomiasis.

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Section: Introductionmentioning

confidence: 99%

The formation of egg granulomas in the spleens of mice with late Schistosoma japonicum infection alters splenic morphology

et al. 2015

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“…Each papule corresponds to the penetration site of a single parasite. 18 Cercarial dermatitis is the short-term immune reaction occurring in the skin of humans that have been infected by the water-borne schistosomatidae. It commonly occurs within hours of infection and generally does not last more than a week.…”

Section: Schistosomiasis Anal Dermatitismentioning

confidence: 99%

Parasitic Infections

Khubchandani¹,

Bub

2019

Clinics in Colon and Rectal Surgery

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Parasitic infections of the gastrointestinal tract are a cause of morbidity to millions of individuals worldwide. These parasites are endemic in underdeveloped countries with poor sanitation allowing for spread through contaminated water supplies. While much is known about these parasites, the cutaneous manifestations caused by infection are infrequently reported in the literature. The deposition of the parasites into the perianal region often leads to significant skin irritation. Cutaneous findings vary from a mild pruritus ani to a macular rash to even severe perianal ulceration. This article discusses the perianal cutaneous findings caused by the parasitic illnesses, amebiasis, schistosomiasis, Enterobius vermicularis, strongyloidiasis, and cutaneous larva migrans, as well as their respective management.

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Parasitic Diseases

Ogawa

Santos

2022

Atlas of Dermatologic Diseases in Solid Organ Transplant Recipients

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Ectopic cutaneous Schistosomiasis

Cited by 5 publications

References 2 publications

The formation of egg granulomas in the spleens of mice with late Schistosoma japonicum infection alters splenic morphology

The formation of egg granulomas in the spleens of mice with late Schistosoma japonicum infection alters splenic morphology

Parasitic Infections

Parasitic Diseases

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