Obesity and dyslipidemia in patients with psoriasis treated at a dermatologic clinic in Manaus

Abstract

BACKGROUND Psoriasis is a chronic inflammatory disease of multifactorial etiology, with participation of genetic, autoimmune and environmental factors. Recent studies have demonstrated the role of inflammatory cells and mediators in the pathogenesis of psoriasis, which is now defined as a systemic and autoimmune inflammatory disease that may be associated with other diseases of inflammatory nature. OBJECTIVES To evaluate the occurrence of obesity and dyslipidemia in patients with psoriasis treated at a dermatology clinic in Manaus. METHODS We performed a prospective descriptive study to assess the prevalence of obesity and dyslipidemia in patients with psoriasis. Besides the recommended dermatological care, a physical examination was performed to measure weight, height and waist circumference. RESULTS We included 72 patients, 44 (61.1%) female and 28 (38.9%) male, with a mean age of 51.0 years ± 15.9 years. As for body mass index (BMI), 16 (22.2%) were overweight and 20 (27.8%) were obese. In the analysis of waist circumference in relation to gender, we found that 79.5% of women surveyed had central obesity, a percentage statistically higher than that observed among men (42.9%) at the 5% level of significance (p = 0.001). Regarding the diagnosis of dyslipidemia, 29 (65.9%) females and 22 (78.6%) males showed alterations in lipid profile. CONCLUSIONS The occurrence of dyslipidemia and obesity in patients with psoriasis can affect life quality and expectancy, increasing the risk of systemic and metabolic diseases, which makes periodic investigation of these comorbidities in patients with psoriasis mandatory.

Psoriasis Vulgaris with or without Arthritis and Independent of Disease Severity or Duration Is a Risk Factor for Hypercholesterolemia

“…Since 1987, numerous studies have been conducted to study DL in Ps [1,2,5,6,7,8,9,10,11,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46]. The results vary since they are based on heterogeneous populations, with or without associated comorbidities, and do not always take into account prescribed medications that can alter the lipid profile or liver function tests [29,30,31,32,33,34,35].…”

“…Several studies have focused on the relationship between Ps and cardiovascular risk factors [5,6,7,8,9,10,11]. Recently a systematic review, two meta-analyses and a population-based study have been published with different results [2,5,10,11].…”

Nutrition and psoriasis: is there any association between the severity of the disease and adherence to the Mediterranean diet?

“…Obesity is an important risk factor for psoriasis [ 14 ]. The relationship between the two conditions is probably bidirectional, with obesity predisposing to psoriasis and psoriasis favoring obesity [ 15 ].…”

Presence of selected metabolic syndrome components in patients with psoriasis vulgaris

“…Increase in the risk of developing hypertension, diabetes and hyperlipidemia is statistically significant. Abdominal obesity is also more common in these patients [ 9 ]. Moreover, disorders found in patients with metabolic syndrome such as insulin resistance, hyperinsulinemia, endothelial dysfunction, chronic inflammation, increase in oxidative stress, abdominal obesity, dysregulated adipokine secretion and non-alcoholic fatty liver disease are also observed in psoriatic patients.…”