Epidemiological and histopathological profile of cutaneous melanoma at a center in northeastern Brazil from 2000 to 2010

Vilanova, Camila; Lages, Rafael Bandeira; Ribeiro, Sahâmia Martins; Almeida, Isabella Parente; Santos, Lina Gomes dos; Vieira, Sabas Carlos

doi:10.1590/abd1806-4841.20132036

Cited by 16 publications

(19 citation statements)

References 21 publications

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“…Acral melanomas, the less common subtype in the country, were more frequent in the North West and East regions with a higher frequency in females than in males. As it happened in Argentina, similar differences in frequency for the predominant subtype within the country were also described for the Brazilian population [28]. When studying histology frequency by age, Argentinean patients with Acroleniginous lesions were diagnosed at older ages.…”

Section: Discussionsupporting

confidence: 56%

“…Nevertheless, it's important to mention that in 24% of cases, the specific site of the tumour was not provided. Series from some Latin-American countries have shown nodular melanomas as the predominant subtype, followed by superficial spreading, acrolentiginous and lentigo melanomas [28,29]; or, followed by lentigo [23] or acrolentiginuous melanomas [30]. In this study, as for high CM incidence areas worldwide, the most frequent histology in the country, and for the Centro and Patagonia regions, was the SSM.…”

Section: Discussionmentioning

confidence: 62%

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Cutaneous melanoma in Argentina: an analysis of its characteristics and regional differences

Loria¹,

Abriata²,

Santoro³

et al. 2020

ecancer

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Purpose: This study aims to increase the knowledge about the characteristics of cutaneous melanoma in Argentina, their association with the risk of having Breslow ≥1 mm and mortality trends for the period 2002-2017.Patients and methods: Descriptive statistics and regression analyses were done for 10.199 cases within the Argentine Melanoma Registry in the period 2002-2018. Trends in age-standardised mortality rates (ASMR) were analysed using the Join point Regression Model.Results: Cases showed lesions mainly located in males' trunk (37%) and in females' lower limbs (29%). The level of invasion was higher in males who also showed higher mortality. Cases from the North West and North East regions showed a major risk of Breslow >1 mm and harboured CM in lower limbs more frequently than in other regions. Nearly, 25% of tumours over 2 mm were in cases aged <50 years and 37.6% in patients ≥50 years. In the North West, North East and Patagonia, the frequency of cases in young people was higher than in older people. In 43% of cases, the melanoma subtype was not specified in the report. The number of superficial spreading melanomas, the most common histology, was nearly twice that of Nodular melanomas the following histology in importance (3,403 and 1,754, respectively). Melanoma mortality rates in all Argentine population increased in the elderly. Lower melanoma mortality rates were observed in the North West. In 2007-2017, ASMR decreased significantly in females (average 1.4% p/year) while it increased nonsignificantly in males (0.4% p/year).The tumours with the worst prognosis were associated with the elderly, males, nodular or acrolentiginous morphologies, residing somewhere other than Centro and Patagonia and with tumors located in the head/neck and legs. Conclusion:The geographical variations found for melanoma characteristics and their mortality in Argentina, makes it imperative that epidemiological research is continued to avoid generalisations and improve future preventive actions.

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Section: Discussionsupporting

confidence: 56%

Section: Discussionmentioning

confidence: 62%

Cutaneous melanoma in Argentina: an analysis of its characteristics and regional differences

Loria¹,

Abriata²,

Santoro³

et al. 2020

ecancer

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“…Low values of local recurrence in 8 patients (5.3%), locoregional metastases in 7 patients (4.7%), and distant metastases in 7 patients (4.7%) confirm the rather low spreading rate of LMM [11]. Similarly, Ettl et al [8] found 5.2% tumor recurrence for LMM compared to 37.5% for desmoplastic and 42.3% for nodular melanoma.…”

Section: Discussionmentioning

confidence: 79%

“…Apparently, LMMs affecting predominantly elderly people are mainly caused by long-term exposure to ultraviolet (UV) light, which is the most widely accepted risk factor, since UV radiation damages the DNA directly [9-11]. Therefore, it is not surprising that the head and neck region is the location of emergence [12].…”

Section: Introductionmentioning

confidence: 99%

A Retrospective Cohort Study on Patients with Lentigo Maligna Melanoma

et al. 2019

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Background: More epidemiological data about lentigo maligna melanoma (LMM) are required to define follow-up guidelines. The study focused on recurrence, progression, and overall survival of LMM managed with primary wide local excision. Methods: In a 23-year retrospective study (1994 to 2016), a cohort of patients with LMM was evaluated by collecting data about the tumor location, the Breslow depth, the presence of ulceration, and patients’ age and sex. Local recurrences, locoregional and distant metastases, and disease-free and overall survival were additionally assessed. Results: Overall, 150 cases (84 male, 66 female, mean age 71.3 ± 11.3 years) of single, localized, primary LMM with a mean follow-up of 6.6 ± 4.4 years were included. A total of 33 (22.2%) patients underwent sentinel lymph node biopsy (SLNB) during surgical excision. However, positive SLNB was detected in none of them. The multivariable Cox analysis indicated that age of diagnosis and male gender significantly influenced the overall survival, while a shorter disease-free survival could be correlated with a greater Breslow thickness. The metastatic potential turned out to be low, entailing 7 deaths in the context of the LMM. Conclusion: Male gender, age over 70 at diagnosis, and a Breslow thickness greater than 0.75 mm were associated with a statistically significant decrease in overall disease-free survival in the current study. The results of the study confirm the favorable outcome of LMM. However, diagnosed patients should undertake regular follow-ups. The intensity of follow-up in these patients can be individualized based on the probability of recurrence/metastasis and overall survival. Furthermore, the study showed that SLNB might not be a necessary staging procedure in patients with LMM.

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“…In regions with vast contingent of non-white population, such as Asia, Africa, and part of America, ALM is a major concern, as it occurs in populations and skin areas that are not generally at risk for skin cancer, leading frequently to late diagnosis and low survival rates [6][7][8]. In Brazil, a country with high miscegenated and heterogeneous population with African, European and indigenous heritage, ALM is prevalent in some geographic areas [9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Molecular profiling, including TERT promoter mutations, of acral lentiginous melanomas

et al. 2016

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Acral lentiginous melanoma (ALM) is the less common subtype with singular characterization. TERT (human telomerase reverse transcriptase) promoter mutations have being described as recurrent in melanomas and infrequent in ALM, but their real incidence and clinical relevance is unclear. The objectives of this study were to describe the prevalence of TERT promoter mutations in ALM, and correlate with the molecular profile of other drive genes and clinical features. Sixty-one samples from 48 patients with ALM were analyzed. After DNA isolation, the mutation profiles of the hotspot region of BRAF, NRAS, KIT, PDGFRA, and TERT genes were determined by PCR amplification followed by direct Sanger sequencing. KIT, PDGFRA, and VEGFR2 gene amplification was performed by quantitative PCR. Clinical information such as survival, clinical stage, and Breslow tumor classification were obtained from medical records. TERT promoter mutations were found in 9.3% of the cases, BRAF in 10.3%, NRAS in 7.5%, KIT in 20.7%, and PDGFRA in 14.8% of ALM. None of the cases showed KIT, PDGFRA, or VEGFR2 gene amplification. We found an association between KIT mutations and advanced Clark level (IV and V, P=0.043) and TERT promoter mutations with low mitotic index. No other significant associations were observed between mutation profile and patients' clinical features nor survival rates. Oncogenic TERT promoter mutations are present in a fraction of ALMs. No relevant associations were found between TERT mutation status and clinical/molecular features nor survival. Mutations of KIT and PDGFRA are the most common genetic alterations, and they can be therapeutic targets for these patients.

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Epidemiological and histopathological profile of cutaneous melanoma at a center in northeastern Brazil from 2000 to 2010

Cited by 16 publications

References 21 publications

Cutaneous melanoma in Argentina: an analysis of its characteristics and regional differences

Cutaneous melanoma in Argentina: an analysis of its characteristics and regional differences

A Retrospective Cohort Study on Patients with Lentigo Maligna Melanoma

Molecular profiling, including TERT promoter mutations, of acral lentiginous melanomas

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