Randomized clinical efficacy of superficial peeling with 85% lactic acid versus 70% glycolic acid

Abstract

BACKGROUND:Peeling is a procedure which aims to accelerate the process of skin exfoliation.OBJECTIVES Development of formulations containing lactic acid at 85% or glycolic acid at 70% and the evaluation of these formulations on clinical efficacy in reduction of fine wrinkles. METHODS Preliminary stability tests were carried out and an in vivo study was performed with three groups with 9 representatives each. One was the control group, which used only sunscreen; another one used lactic acid+sunscreen, and the last group used acid glycolic+sunscreen. Clinical efficacy was assessed with a CCD color microscope, through the digitization of images before and after treatment. The applications were carried out by a dermatologist, once a mont h every 30 days, during 3 months. The area with wrinkles was calculated by planimetry point counting, in accordance with Mandarin-de-Lacerda. RESULTS The formulations were stable in the visual and Ph evaluation. There was no improvement in the control group; for lactic acid, there was significant improvement after the second peeling application on the outer lateral area of the right eye and after the third application on the outer lateral area of the left eye. For the glycolic acid group, there was significant improvement in the outer lateral area of the left eye after the first application, and of the right eye region, after three applications. The formulations used must be kept under refrigeration and should be manipulated every 30 days. CONCLUSIONS Both peelings were effective in reducing fine wrinkles of the outer lateral eye area after three applications (p≤0.05%). It was observed that peeling efficacy in the external-lateral region of one eye might be different compared with that in skin of the external-lateral region of the other eye, relative to the speed of skin improvement.

Minimally Invasive Cosmetic Procedures in Ethnic Skin: A Review

“…A randomized controlled trial was performed on 27 patients FST II-IV receiving 3 procedures either containing 70% GA, 85% lactic acid or sunscreen as a control at monthly intervals for periorbital wrinkles. The study ultimately found that both GA and LA could significantly improve wrinkling after 3 procedures (p<0.005) [70].…”

Skin Aging & Modern Age Anti-aging Strategies

“…Lactic Acid (LA): Lactic acid (as sodium lactate) is a well-known part of the skin's natural moisturizing complex, and is considered to be an excellent moisturizer.LA also contributes to the cell cycle in human keratinocytes [107].Treatment with 12% LA resulted in increased epidermal and dermal firmness and thickness and clinical improvement in skin smoothness and in the appearance of lines and wrinkles.Both the lactic and glycolic acid peelings were effective in reducing fine wrinkles on the external-lateral region of the eyes, after three applications (85% LA versus 70% GA) [109]. Recently more attention has been drawn to alpha hydroxy and polyhydroxy acids (AHA and PHA) due to their excellent moisturizing and antioxidant properties.Algiert-Zielińska et.al, 2019 reported maintenance of the epidermal barrier integrity during application of lactic acid (LA) and lactobionic acid and the opportunity to use them on sensitive skin types including couperose skin [112].…”

Skin Aging & Modern Age Anti-Aging Strategies

“…Treatment with 12% LA resulted in increased epidermal and dermal irmness and thickness and clinical improvement in skin smoothness and in the appearance of lines and wrinkles. Both the lactic and glycolic acid peelings were effective in reducing ine wrinkles on the external-lateral region of the eyes, after three applications (85% LA versus 70% GA) [107]. Recently more attention has been drawn to alpha hydroxy and polyhydroxy acids (AHA and PHA) due to their excellent moisturizing and antioxidant properties.…”