Correlation between location, size and histologic type of colorectal polyps at the presence of dysplasia and adenocarcinoma

Abstract

Adenocarcinoma represents 96-98% of colorectal neoplasms, and neoplastic polyps (adenomas) are their precursors. The aim of this study is to correlate size, location and histologic type of colorectal polyps at the presence of dysplasia and adenocarcinoma. Methods: Colonoscopies from January/2007 to December/2008 were retrospectively studied, in order to evaluate the characteristics of the polyps. Results and Discussion: Out of the 2,401 analyzed colonoscopies, 583 (24.3%) presented polyps. Due to the lack of histopathologic data, 139 exams were excluded. Mean age of the patients was 58±12 years, and 60% were females. Polyps were prevalent in the left colon (38.5%) and rectum (32.5%). Out of the 850 polyps which were histologically examined, 55.17% were tubular adenomas; 21.88%, hyperplastic; 17.05%, serrated; 5.4%, tubulovillous; and 0.47%, villous. As to polyps £1.0 cm, dysplasia was observed in 16.0% and adenocarcinoma in 1.9%. Those >1.0 cm, 72.0% (p<0.001) presented dysplasia, and 25.3% (p<0.001) presented adenocarcinoma. Polyps in the right and transverse colon were strongly associated with dysplasia (17.8% and 16.7%). Adenocarcinomas were prevalent in the left colon (2.5%) and rectum (2.1%). Conclusion: Polyps were more frequent in the left colon and rectum. The right and transverse colons were strongly correlated with dysplasia. Those of the left colon and rectum were associated with adenocarcinoma. Lesions >1.0 cm were positively related to dysplasia and neoplasm.<br>O adenocarcinoma representa 96-98% do câncer colorretal, sendo os pólipos neoplásicos (adenomas) seus precursores. O objetivo desse estudo é correlacionar tamanho, localização e tipo histológico de pólipos colorretais com a presença de displasia e adenocarcinoma. Métodos: Estudou-se retrospectivamente colonoscopias realizadas entre janeiro/2007 e dezembro/2008, avaliando-se as características dos pólipos. Resultados e Discussão: Das 2401 colonoscopias analisadas, 583 (24,3%) apresentaram pólipos. Por falta de dados histopatológicos, excluiu-se 139 exames. A média de idade foi 58±12 anos, sendo 60% mulheres. Houve predomínio no cólon esquerdo (38,5%) e reto (32,5%). Quanto ao tamanho, 86,58% eram £1 cm. Dos 850 pólipos analisados histologicamente, 55,17% eram adenomas tubulares, 21,88% hiperplásicos, 17,05% serrilhados, 5,4% tubulovilosos e 0,47% vilosos. Dos pólipos £1,0 cm, 16,0% apresentaram displasia e 1,9% adenocarcinoma; dos >1,0 cm houve displasia em 72,0% (p<0,001) e adenocarcinoma em 25,3% (p<0,001). Pólipos do cólon direito e transverso associaram-se mais à displasia (17,8% e 16,7%, respectivamente). Adenocarcinoma predominou no cólon esquerdo (2,5%) e reto (2,1%). Conclusão: Os pólipos predominaram em cólon esquerdo e reto. Os do cólon direito e transverso correlacionam-se fortemente à displasia, e os do reto e cólon esquerdo ao adenocarcinoma. Lesões maiores que 1,0 cm associaram-se positivamente com a presença de displasia e neoplasia

Effects of propolis and gamma‐cyclodextrin on intestinal neoplasia in normal weight and obese mice

“…Our mouse model is limited to the precarcinoma stage. However, even at this stage, the size of adenomas strongly correlates with the grade dysplasia; large adenomas usually display high‐grade dysplasia, and vice versa , smaller in size adenomas exhibit lower grade of dysplasia [ ]. Since adding gamma‐cyclodextrin and propolis to control or Western diets decreased the number of large (>10 mm 2 ) adenomas (Fig.…”

Clinicopathologic Features of Colorectal Polyps in Shahid Beheshti University of Medical Sciences (SBMU)

“…Studies have been showed that approximately two-third of patients had solitary polyps, and advanced age is associated with detecting larger polyps (Lowenfels et al, 2011;Silva et al, 2014;Solakoğlu et al, 2014) Of the 1,106 polyps, adenomatous polyps were the most prevalent types, followed by mucosal tags/polyps, hyperplastic and serrated polyps, inflammatory polyps, hamartomatous, and malignant lesions. Frequency of adenomatous polyps in selected Iranian studies ranged between 61% and 90% (Mirzaie et al, 2012;Darvish et al, 2013;Iravani et al, 2014;Delavari et al, 2014;Hajmanoochehri et al, 2014;Geramizadeh and Keshtkar-Jahromi, 2013), and in some other countries varies between 41% and 61% (Zhou et al, 2017;Kefeli et al, 2014;Wickramasinghe et al, 2014;Valarini et al, 2011). It seems that in some of the mentioned studies in Iran, due to over-diagnosis of non-neoplastic polyps under Most polyps, including adenomas, located in the left colon, especially rectosigmoid.…”

“…In Iranian studies, this group accounts for 0.3% to 2.1% of all polyps (Mirzaie et al, 2012;Iravani et al, 2014;Delavari et al, 2014;Hajmanoochehri et al, 2014;Geramizadeh and Keshtkar-Jahromi, 2013), and in other countries, this group constitutes 2% to 17% of all colonic polyps (Zhou et al, 2017;Kefeli et al, 2014;Wickramasinghe et al, 2014;Valarini et al, 2011). It seems that either these types of colonic polyps in Iran are not as common as western countries, or they remain undetected and misclassified as other polyps especially hyperplastic ones.…”

“…In a study at Hazrat Rasul Akram Hospital., as a pure group it accounts for 4.8% of all polyps, but in another review and as a combined class with inflammatory polyps this group constitutes 16% to 31% of all colonic polyps (Mirzaie et al, 2012). In series from other countries, this group accounts for 17% to 50% of all colonic polyps (Zhou et al, 2017;Kefeli et al, 2014;Wickramasinghe et al, 2014;Valarini et al, 2011).…”

“…Hamartomatous polyps comprise 21(1.9%) of all cases. This group accounts for 4%-5% of colon polyps (Zhou et al, 2017;Kefeli et al, 2014;Wickramasinghe et al, 2014;Valarini et al, 2011). In most Iranian published articles, they account for 2% up to 11% of colon polyps (Eshghi et al, 2011;Mirzaie et al, 2016;Mirzaie et al, 2012;Iravani et al, 2014).…”