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Aims: Familial aggregation of the metabolic syndrome has been reported in some nations. The aim of this study was to evaluate familial aggregation of the metabolic syndrome in Tehranian families. Methods: In a cross-sectional study, anthropometry, blood pressure and biochemical data were collected for 4,558 individuals in the Tehran Lipid and Glucose Study. Variables of the metabolic syndrome in offspring were correlated with those of their parents. Results: There were 1,274 fathers, 1,576 mothers, 802 sons and 906 daughters. Prevalence of metabolic syndrome was 24.4% for fathers, 39.7% for mothers, 9.0% for sons and 7.6% for daughters. Triglycerides and HDL-C of children whose fathers had metabolic syndrome, and BMI, triglycerides and HDL-C of those whose mothers had it were significantly different from those adolescents whose parents were free of metabolic syndrome. Compared with children whose parents did not have metabolic syndrome, the odds ratio (confidence interval) for children with both parents having metabolic syndrome was 4.53 (2.42–8.8) for metabolic syndrome, 2.22 (1.17–4.19) for abdominal obesity, 1.90 (1.15–3.13) for high blood pressure, 2.66 (1.77–4.00) for low HDL-C and 3.16 (2.10–4.75) for high triglyceride levels. Conclusion: This survey provides evidence suggesting that there is a familial aggregation of the metabolic syndrome among Iranian families.

Neurocysticercosis is a significant public health issue worldwide. Even though cysticercosis was once thought to have been eradicated in the United States, it is currently a growing public health problem in the United States, and immigrants from endemic areas are at the highest risk of acquiring this disease. In Iran, there was no report from this worrisome infection. The clinical presentation of neurocysticercosis is variable and vague. In this article, we will explain a case of neurocysticercosis encountered in the Shohada Hospital pathology department, and then we will review neurologic and radiologic symptoms, laboratory and pathologic findings, as well as medication for treatment, briefly.

Purpose: Involvement of the inferior alveolar nerve (IAN) is important in the prognosis and treatment of gingival squamous cell carcinoma (SCC). Methods: In this cross sectional study, patients with gingival SCC (T4a), undergoing hemimandibulectomy or subtotal hemimandibulectomy, were examined. The distance between the lesion and inferior alveolar canal (IAC) was measured, using axial computed tomography scans before resection. Following that, histopathological evaluation of IAN was conducted. The receiver operating characteristic curve was plotted to determine the association of IAN involvement in histopathological evaluation with various distances between the lesion and IAC. Results: A total of 29 patients were examined in this study. The mean distance between the lesion and IAC was 9.40 ± 2.21 mm. Nerve involvement was documented in 9 (45%) out of 20 males, while 11 (55%) men showed no involvement. Thirteen (44.82%) patients showed IAN involvement. The receiver operating characteristic curve demonstrated a cut-off point of 9.75 mm for the lesion-IAN distance. The possibility of IAN involvement was 23.33 times higher in patients who reported paresthesia, compared with patients without nerve involvement (odds ratio, 23.33; 95% CL; P = 0.001) Conclusion: It seems that in a CT scan view, a 9.75-mm safe margin is associated with high accuracy for preserving IAN in patients with gingival SCC. Also, neurosensory disturbance can be considered a strong predictor of IAN involvement.

Aim:This study was designed to report epidemiologic findings of polyps in Iranian patients, and predict histology of polyp regarding to demographic and colonoscopic findings. Background: Classification of colorectal polyps had been revised in the past two decades and there is a need for polyp categorization in the Iranian Health System. Patients and methods: In this retrospective study, the medical records of patients with colonoscopic diagnosis of polyp in pathology departments of SBMU affiliated teaching hospitals were reviewed. Patient's slides evaluated and demographics findings were assessed. The anatomical location, macroscopic appearance including size and histological assessment of all polyps were recorded. Results: From total number of 1106 polyps (detected in 862 patients), adenomatous polyps (638 [57.7%]) were the most prevalent findings, followed by colon mucosal tag (184[16.6%]), hyperplastic and serrated polyps (122[11%]), inflammatory polyps (110[9.9%]), hamartomatous (21[1.9%]), and malignant lesions (13[1.2%]). Multivariate logistic regression showed age (each one year increasing age; odds ratio [OR] = 1.026, 95%confidence interval [CI] = 1.016-1.036, p < 0.0001), location of polyp (right colon; OR = 1.905, 95%CI = 1.366-2.656, p < 0.0001), and polyp size of 5-10 mm (OR = 1.662, 95%CI = 1.214-2.276, p = 0.002), and polyp size of >10 mm (OR = 2.778, 95%CI = 1.750-4.411, p< 0.0001) were independently associated with neoplastic polyps. Also, polyp size of >10 mm (OR= 2.613, 95%CI= 1.083-6.307, p=0.033), tubulovillous pattern of polyp (OR= 3.508, 95%CI= 1.666-7.387, p=0.001) and villous pattern of polyp (OR= 10.444, p<0.0001) were associated with high grade dysplasia in neoplastic polyps. Conclusion: Increased age, location of polyp (right colon), increased size of polyp and villous component of polyp could classify patients in high risk groups.