Hidratação com bicarbonato de sódio na prevenção de nefropatia induzida por contraste em pacientes diabéticos: subanálise de ensaio clínico multicêntrico

Gomes, Vitor; Tabajara, Camila; Hickmann, Patrícia; Perez-Alva, Juan Carlos; Brito, Fábio Sândoli de; Almeida, Breno Oliveira; Lima, Valter C.; Machado, Bruno Martins; Arruda, Airton; Paula, José Eduardo T. de; Lasevitch, Ricardo; Caramori, Paulo Henrique

doi:10.1590/s2179-83972008000400012

Cited by 1 publication

(3 citation statements)

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“…As a result, evalua ng the eff ect of an oxidants such as sodium bicarbonate may eff ec vely prevent or reduce CIN (19) . This is because several studies have demonstrated its performance in intratubular fl uid, reducing the forma on of free radicals generated by the contact of the contrast medium with the renal tubules (3,11) .…”

Section: Discussionmentioning

confidence: 99%

“…In a randomized prospec ve study, the use of such substances at a concentra on of 154 mEq/L in 119 subjects with serum crea nine levels ≥1.1 mg/dL resulted in 13.6% of the pa ents developing CIN with the use of preven ve sodium chloride and only 1.7% with the use of sodium bicarbonate (19) .…”

Section: Discussionmentioning

confidence: 99%

“…Thus, IC agents are classifi ed into 4 types as follows: ionic high-osmolar, ionic low-osmolar, nonionic low-osmolar, and nonionic iso--osmolar. Among the many physicochemical characteris cs, the osmolality of the IC solu on is, in principle, the most related to the risk of nephrotoxicity (7) .…”

Section: Introductionmentioning

confidence: 99%

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O efeito protetor do bicarbonato de sódio na nefropatia induzida por contraste radiológico em ratos

Vattimo

Santos

2013

Rev. esc. enferm. USP

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714 RESUMOContrastes radiológicos iodados -CI são causa de lesão renal aguda -LRA. Avaliar o efeito renoprotetor do bicarbonato de sódio (Bic) sobre a função renal (clearance de crea nina, Jaff é, Clcr-ml/min/100g) e o perfi l oxida vo (excreção de peróxidos, PU e de malondealdeído urinários, FOX-2 e TBARs, nmol/mgCr ) em ratos com CI. Ratos machos adultos Wistar, 250-300g, tratados 1x/dia, por 5 dias, foram divididos nos grupos: Salina (solução salina 0,9%, 3ml/kg/dia, intraperitoneal-i.p.); CI (ioxitalamato de meglumina e sódio, 3ml/kg, i.p); Bic+Salina (Bic 3ml/kg, i.p, 1 hora antes e 1 hora depois da Salina); Bic+CI (Bic 3ml/ kg, i.p, 1 hora antes e 1 hora depois do CI). DESCRITORES ABSTRACTRadiological iodinated contrasts (IC) agents cause acute kidney injury (AKI). To evaluate the renoprotec ve eff ect of sodium bicarbonate (Bic) on renal func on (crea nine clearance [Clcr], Jaff é, and Clcr mL·min -1 100 g -1 ) and the oxida ve profi le (peroxide excreon, urinary peroxides, urinary malondialdehyde, FOX-2 expression, and thiobarbituric acid reactive substance [TBARS; nmol/mg Cr]) in rats treated with an IC agent. Adult male Wistar rats weighing 250-300 g were treated once daily for 5 days with one of the following treatments: saline (0.9%, 3 mL·kg -1 day -1 intraperitoneally [i.p.]), IC agent (sodium and meglumine ioxitalamate, 3 mL/kg, i.p.), Bic + Saline (3-mL/kg Bic, i.p., 1 h before and a er saline treatment), and Bic + IC (3-mL/kg Bic, i.p., 1 h before and a er the IC treatment). The IC agent induced AKI, and the antioxidant renoprotective effect of Bic was confirmed (Clcr/TBARS/urinary peroxide: saline group, 0.59 ± 0.03/0.11 ± 0.02/1.29 ± 0.24; Bic + Saline group, 0.58 ± 0.03/0.13 ± 0.02/1.32 ± 0.64; IC group, 0.22 ± 0.02/0.19 ± 0.02/4.77 ± 0.24; Bic + CI group, 0.51 ± 0.04/0.13 ± 0.3/1.80 ± 0.04; p<0.05). The protec ve eff ect of Bic in the ICinduced AKI was confi rmed; hence, Bic administra on may be considered as a therapeu c op on for pa ents undergoing IC-enhanced radiography.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%