The influence of protein malnutrition on the production of GM-CSF and M-CSF by macrophages

Oliveira, Dalila Cunha de; Hastreiter, Araceli Aparecida; Borelli, Primavera; Fock, Ricardo Ambrósio

doi:10.1590/s1984-82502016000300003

Cited by 5 publications

(3 citation statements)

References 29 publications

(35 reference statements)

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“… 1 Experimental studies suggested that hematological abnormalities during PEM occur due to alterations of hematopoiesis in the BM, hematopoietic progenitors’ cell cycle, 10 lymphohematopoietic organs, 12 and alteration of the production of colony-stimulating factor by macrophages. 11 …”

Section: Discussionmentioning

confidence: 99%

“…10 PEM alters granulocytemacrophage colony-stimulating factor and macrophage colony-stimulating factor production by macrophages which leads to diminished immune response and blood cell formation and maturation. 11 It also alters lymphohematopoietic organs like BM, spleen, and thymus which leads to anemia, leukopenia, alters the immune system, and increases susceptibility to infections. 12 Low red blood cell (RBC) count resulting anemia has a common feature of PEM.…”

Section: Introductionmentioning

confidence: 99%

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<p>Hematological Abnormalities and Associated Factors Among Undernourished Under-Five Children Attending University of Gondar Specialized Referral Hospital, Northwest Ethiopia</p>

Getawa

Getaneh

Melku

2020

JBM

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Introduction The hematopoietic system is one of the systems which can be affected by malnutrition, leading to impaired production of all blood cell lines. Undernourished children with hematological abnormalities like anemia are at higher risk of mortality. Therefore, this study aimed at determining the magnitude and associated factors of hematological abnormalities among undernourished under-five children attending at the University of Gondar Specialized Referral Hospital, Northwest Ethiopia. Methods and Materials An institution-based cross-sectional study was conducted on a total of 251 undernourished under-five children at University of Gondar Specialized Referral Hospital from January to May 2020. A convenient sampling technique was employed to select study participants. Data were collected using a pretested structured questionnaire. Blood samples were collected for complete blood count which were determined by Sysmex KX-21N analyzer. Stool sample was processed via direct wet mount. Thin and thick blood films were examined to assess malaria parasite. The data were entered to EpiData version 4.6.0.0 and analyzed using SPSS version 23 software. Bi-variable and multi-variable binary logistic regression model were fitted to identify factors associated with hematological abnormalities. A p-value <0.05 in the multivariable analysis was considered as statistically significant. Results The overall magnitude of anemia, leukocytosis, thrombocytosis, thrombocytopenia, and leukopenia was 53.4%, 26.7%, 23.9%, 8%, and 2.8%, respectively. Being male, age 6–23 months, high birth order, intestinal parasite infection, edema, not eating vegetables and fruits, and paternal occupation were found to be associated with anemia. Only the age of a child was associated with leukocytosis in undernourished children. Conclusion The current study demonstrated the predominant existence of anemia, leukocytosis, and thrombocytosis among undernourished under-five children. Therefore, early diagnosis, monitoring and setting intervention strategies for anemia especially among children under two years old are required to prevent further complication.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

<p>Hematological Abnormalities and Associated Factors Among Undernourished Under-Five Children Attending University of Gondar Specialized Referral Hospital, Northwest Ethiopia</p>

Getawa

Getaneh

Melku

2020

JBM

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“…Likewise, Mφ from mice fed a low protein diet demonstrated increased Leishmania infantum parasite burden compared to those isolated from nourished mice [110]. Suppressed NFκB activity [111] and reduction in the production of GM-CSF growth factor [112] and ROS and NO [113] were also observed in peritoneal and alveolar Mφ isolated from malnourished (vs. nourished) animals, suggesting poor Mφ inflammatory function in nutrition-deficient states. These studies point to the importance of nutritional availability for Mφ to prompt a proinflammatory response, and delineating the mechanism of how metabolic deficiency links to function of Mφ in malnourished states will be useful to define novel methods for improving infection outcomes.…”

Section: Relevance Of Mφ Function In Metabolic Disordersmentioning

confidence: 99%

Metabolic programming of macrophage functions and pathogens control

Koo

Garg

2019

Redox Biology

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Macrophages (Mφ) are central players in mediating proinflammatory and immunomodulatory functions. Unchecked Mφ activities contribute to pathology across many diseases, including those caused by infectious pathogens and metabolic disorders. A fine balance of Mφ responses is crucial, which may be achieved by enforcing appropriate bioenergetics pathways. Metabolism serves as the provider of energy, substrates, and byproducts that support differential Mφ characteristics. The metabolic properties that control the polarization and response of Mφ remain to be fully uncovered for use in managing infectious diseases. Here, we review the various metabolic states in Mφ and how they influence the cell function.

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Exploring the protective mechanisms of total tannins from Geum japonicum var. chinense F.Bolle in mice with hematopoietic dysfunction via the JAK2/STAT3/5 signaling pathway

et al. 2022

Journal of Ethnopharmacology

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The influence of protein malnutrition on the production of GM-CSF and M-CSF by macrophages

Cited by 5 publications

References 29 publications

<p>Hematological Abnormalities and Associated Factors Among Undernourished Under-Five Children Attending University of Gondar Specialized Referral Hospital, Northwest Ethiopia</p>

<p>Hematological Abnormalities and Associated Factors Among Undernourished Under-Five Children Attending University of Gondar Specialized Referral Hospital, Northwest Ethiopia</p>

Metabolic programming of macrophage functions and pathogens control

Exploring the protective mechanisms of total tannins from Geum japonicum var. chinense F.Bolle in mice with hematopoietic dysfunction via the JAK2/STAT3/5 signaling pathway

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