Genotoxic and chromatographic analyses of aqueous extracts of Peltodon longipes Kunth ex Benth. (hortelã-do-campo)

Kuhn, Andrielle Wouters; Tedesco, Marino José; Boligon, Aline Augusti; Frescura, Viviane Dal-Souto; Athayde, Margareth Linde; Tedesco, Solange Bósio

doi:10.1590/s1984-82502015000300005

Cited by 2 publications

(1 citation statement)

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“…102887935 (Su 2013), a method to extract asprellic acid from H. capitata; Patent No. WO 9843608 (Greff 1998), a cosmetic composition for lightening the skin and eliminating freckles In Antioquia and Chocó, it is used by traditional healers for snakebites (Otero et al 2000); it is used as a medicinal plant by the Cayapa Indigenous people from Peru to cure fungal diseases (Kvist and Holm-Nielsen 1987); it is used as a medicinal plant in Taiwan against colds, fever, and asthma (Lee et al 1988) (Fronza 2011;Fronza et al 2012) Genotoxic potential: aqueous extracts showed an anti-proliferative effect and absence of genotoxicity on Allium cepa (Kuhn et al 2015) In Brazil, it is used as a stimulant and emmenagogue (Kuhn et al 2015) H. conferta Antioxidant activity: antiradical activity (DPPH) (Tafurt-García et al 2016) H. crenata Antibacterial activity: essential oil active against Staphylococcus aureus, Enterococcus faecalis (Violante et al 2012b); ethanol, hexane, dichloromethane, ethyl acetate, and hydromethanol extract active against Escherichia coli, Klebsiella pneumonia, Pseudomonas aeruginosa, E. faecalis, S. aureus (Violante et al 2012a) Antifungal activity: Candida krusei, C. parapsilosis, Cryptococcus neoformans (Violante et al 2012a); ethanol systemic effect against the cucumber (Cucumis sativus L.) powdery mildew (Sphaerotheca fuliqinea) (Stadnik et al 2003) Antinociceptive effect: decoction had antinociceptive effects in two mouse models of pain (Rocha et al 2013); decoction showed no mortality of 8C57/BL6 mice (Rocha et al 2009) Antioxidant activity: antiradical activity of methanol extract (DPPH), Trolox equivalent of 226.8 mg TE g −1…”

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confidence: 99%

A review of the phytochemical profiling and biological activities of Hyptis Jacq.: a Brazilian native genus of Lamiaceae

et al. 2020

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Hyptis Jacq. (Lamiaceae) has been used in traditional medicine for the treatment of many diseases around the world. However, Harley and Pastore in 2012 proposed a new circumscription for this large genus, reducing its number of species, but supporting its monophyly. Hyptis and Peltodon were used as keywords, and triage of articles was performed using genus delimitation sensu Harley and Pastore. Only 29 species have some type of record in the literature for their medicinal use and chemical description, corresponding to 20% of the 148 species. Most cited biological activities were the antioxidant activity, reported for 9% of the species, and the antifungal activity reported for 5% of the species. For 11% of the species was described the essential oil composition, while non-volatile compounds were reported for only 6% of them. Terpenes, flavonoids, and caffeic acid derivatives are the most reported compounds for this genus. Only 8% of the species are reported as medicinal, with potential as antibacterial and antiparasitic, pointing to relevance of Hyptis to bioprospecting studies, especially in South America and Africa. However, there is a lack of studies regarding isolated compounds concerning their toxicology and efficacy, important information to achieve the production and the effective use of Hyptis as a herbal medicine.

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