Dissolution efficiency and bioequivalence study using urine data from healthy volunteers: a comparison between two tablet formulations of cephalexin

Serra, Cristina Helena dos Reis; Chang, Kyung Hee; Dezani, Thaisa Marinho; Porta, Valentina; Storpirtis, Sílvia

doi:10.1590/s1984-82502015000200016

Cited by 8 publications

(5 citation statements)

References 20 publications

(33 reference statements)

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“…Cefalexina e amoxicilina, o primeiro e o segundo mais prescritos, são beta-latâmicos inibidores da parede celular bacteriana, sendo o primeiro pertencente ao grupo das cefalosporinas semissintéticas de primeira geração e o segundo ao grupo das penicilinas semissintéticas (17,18). A amoxicilina, geralmente, é prescrita em associação a um inibidor da beta-lactamase, como sulbactam ou ácido clavulânico (18).…”

Section: Resultsunclassified

“…O quarto, azitromicina, é um macrolídeo inibidor da síntese de proteínas bacterianas, utilizado no tratamento das infecções bacterianas do trato respirató-rio, e também nas infecções da pele e dos tecidos moles (19,20). Todos os antimicrobianos citados apresentam amplo espectro de ação principalmente contra bactérias aeróbias (1,2,(17)(18)(19)(20).…”

Section: Resultsunclassified

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Prescrições De Antibacterianos Em Uma Drogaria Do Município De Tanabi, São Paulo, Brasil

Lima

Silva

Pereira

et al. 2017

Infarma

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Antimicrobial drugs are substances able to prevent the proliferation or death of infectious agents, combating and preventing the dissemination of an infection. The abusive or inappropriate use of these drugs leads to the development of strains of multi-resistant microrganisms. The aim of this study was to describe the antimicrobial drug consumption in a drugstore at Tanabi, São Paulo, Brazil. This is a retrospective, descriptive, exploratory study with a quantitative approach. There were analyzed 128 prescriptions containing antimicrobial drugs dispensed in 2016. 64% of the prescriptions were destined to the female gender. The average age was 46 ± 25 years. The most prescribed antimicrobials were cephalexin (23%), amoxicillin associated with clavulanate (22%), ciprofloxacin (17%) and azithromycin (15%). Consequently, the most commonly used pharmacological groups were beta-lactams (55%), fluoroquinolones (30%) and macrolides (15%), respectively. The most frequent prescribers were general phisicians (42%), dentist (12%), cardiologist (9%) and urologist (7%). Most of the prescriptions came from the private health system (54%). The prescribers used the trade name in 55% of the prescribed antimicrobials, of which 33% were destined to the public health system. This research contributes to evaluation of the use of antimicrobial drugs in population. The effective action of the Pharmacist in the control the use of antibacterials in accordance with current legislation is important to provide the population with adequate guidelines on the rational use of these agents.

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Section: Resultsunclassified

Prescrições De Antibacterianos Em Uma Drogaria Do Município De Tanabi, São Paulo, Brasil

Lima

Silva

Pereira

et al. 2017

Infarma

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“…It is obvious that using Q0.5 h as a release parameter involves comparison of single release points in order to evaluate the ability of the investigated formulations to release a fast initial dose of the loaded drug. On the other hand, the concept of RE% has some advantages over the single point parameter, the most important being that it can be theoretically related to in vivo data [65].…”

Section: Effect On In Vitro Release Studiesmentioning

confidence: 99%

Intranasal Zolmitriptan-Loaded Bilosomes with Extended Nasal Mucociliary Transit Time for Direct Nose to Brain Delivery

et al. 2021

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This study aimed at delivering intranasal zolmitriptan directly to the brain through preparation of bilosomes incorporated into a mucoadhesive in situ gel with extended nasal mucociliary transit time. Zolmitriptan-loaded bilosomes were constructed through a thin film hydration method applying Box–Behnken design. The independent variables were amount of sodium deoxycholate and the amount and molar ratio of cholesterol/Span® 40 mixture. Bilosomes were assessed for their entrapment efficiency, particle size and in vitro release. The optimal bilosomes were loaded into mucoadhesive in situ gel consisting of poloxamer 407 and hydroxypropyl methylcellulose. The systemic and brain kinetics of Zolmitriptan were evaluated in rats by comparing intranasal administration of prepared gel to an IV solution. Statistical analysis suggested an optimized bilosomal formulation composition of sodium deoxycholate (5 mg) with an amount and molar ratio of cholesterol/Span® 40 mixture of 255 mg and 1:7.7, respectively. The mucoadhesive in situ gel containing bilosomal formulation had a sol-gel temperature of 34.03 °C and an extended mucociliary transit time of 22.36 min. The gelling system possessed enhanced brain bioavailability compared to bilosomal dispersion (1176.98 vs. 835.77%, respectively) following intranasal administration. The gel revealed successful brain targeting with improved drug targeting efficiency and direct transport percentage indices. The intranasal delivery of mucoadhesive in situ gel containing zolmitriptan-loaded bilosomes offered direct nose-to-brain drug targeting with enhanced brain bioavailability.

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“…This study used a concentration of 4 PPM, 8 PPM, 16 PPM, 20 PPM, and 24 PPM. The dissolved quercetin was then read for its absorbance using spectrophotometry with a wavelength of 435 nm [12]. After obtaining the absorbance of each concentration, the standard curve value was calculated.…”

Section: Tablet Dissolution Testmentioning

confidence: 99%

The Possible Antidiabetic Effect of Ficus carica L. Tablet on lloxan-Induced Diabetes Model in Rats

Kurniawan

Yusuf

2021

Open Access Maced J Med Sci

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BACKGROUND: Fig leaves are reported to have an effect on reducing blood glucose levels. However, the use of fresh leaves makes the effects obtained is not measurable and efficient. AIM: The purpose of this research was to determine the antidiabetic potential of ethanol extract of fig leaves and to optimize tablet dosage formulations. METHODS: Four tablet formulas were made using the wet granulation method. Formula I (FI), Formula I (FII), and Formula III (FIII) groups to give a tablet of ethanol extract of fig leaves with a dose of 40 mg, 60 mg, and 80 mg and placebo treatment group. There were eight groups of male rats strain Wistar treated as follows: Normal control, negative control, positive control (metformin tablets), basis group, placebo treatment group, F1, F2, and F3 groups. The antidiabetic activity was evaluated from a decrease in rat blood glucose levels. Previously, rats were induced first using alloxan 150 mg/kg intraperitoneally to damage β-pancreatic cells so that the rats could experience increased blood glucose levels. After giving treatment to each group for 14 days, a rat blood sample was then taken on days 9 and 14, which were then analyzed by the GOD PAP method with readings carried out using a spectrophotometer with a wavelength of 500 nm. RESULTS: The average weight (mg) of FI tablets (617.8 ± 3.21%), FII (629.35 ± 8.16%), and FIII (643.6 ± 6.21%), and placebo tablet (666.45 ± 4.36%). As for the uniformity of size, all formulas have a diameter of 0.9 ± 0.0 (cm). For the hardness values of FI (5.7 kg), FII (1.31 kg), and FIII (3.09 kg), placebo tablet (2.98%). The value of friability FI (1.42%), FII (11.8%), and FIII (0.84%), placebo tablet (1.16%). While the disintegration time of FI (11.02 min), FII (10.10 min), and FIII (17.00 min), placebo tablet (12.23%). As for the uniformity of size, all formulas have a diameter of 0.9 ± 0.0 (cm). Whereas the dissolution rate (DE45) of each formulation decreased with increasing dose of extract, FI (73.73%), FII (74.80%), and FIII (69.80%). The treatment group of the ethanol extract of fig leaves at a dose of 40 mg, ethanol extract of fig leaves at a dose of 60 mg, and ethanol extract of fig leaves at a dose of 80 mg could reduce rats’ blood glucose levels with statistically significant results (p < 0.05) compared to negative group. When it was compared to the positive group, it had significant results with a statistical value (p < 0.05). CONCLUSION: Ethanol extract of fig leaf tablets had a significant effect on lowering rats’ blood glucose levels.

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Dissolution efficiency and bioequivalence study using urine data from healthy volunteers: a comparison between two tablet formulations of cephalexin

Cited by 8 publications

References 20 publications

Prescrições De Antibacterianos Em Uma Drogaria Do Município De Tanabi, São Paulo, Brasil

Prescrições De Antibacterianos Em Uma Drogaria Do Município De Tanabi, São Paulo, Brasil

Intranasal Zolmitriptan-Loaded Bilosomes with Extended Nasal Mucociliary Transit Time for Direct Nose to Brain Delivery

The Possible Antidiabetic Effect of Ficus carica L. Tablet on lloxan-Induced Diabetes Model in Rats

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