Screening of mucoadhesive vaginal gel formulations

Andrade, Ana Ochoa; Parente, María Emma; Ares, Gastón

doi:10.1590/s1984-82502014000400029

Cited by 24 publications

(17 citation statements)

References 28 publications

(38 reference statements)

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“…Table I. Based on results of a previous work, in which hydrogels developed using the same polymers were characterized using rheological and spreadability measurements [19], the combination of Cg and Gg was not included in the present work. Hydrogels 1 and 5 (CbPe0.5 and CbXg1.5) were also formulated including 2% of caffeine to perform active release studies.…”

Section: Preparation Of Hydrogelsmentioning

confidence: 99%

Bioadhesive hydrogels for cosmetic applications

Parente

Andrade

Ares

et al. 2015

Intern J of Cosmetic Sci

108

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Physico-chemical and sensory techniques enabled the identification of bioadhesive hydrogel formulations with positive characteristics for cosmetic applications. Formulations which combined carbomer homopolymer type C with xanthan gum or with carbomer copolymer type B were the most promising for bioadhesive skin products. Caffeine release profiles of selected formulations were not statistically different. Both hydrogels gradually released the active ingredient, reaching approximately 80% within the first 5 h, and their profiles were well described by the Higuchi model. In this context, it could be concluded that the selected hydrogels are suitable bioadhesive hydrogel formulations for cosmetic application on the skin.

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Section: Preparation Of Hydrogelsmentioning

confidence: 99%

Bioadhesive hydrogels for cosmetic applications

Parente

Andrade

Ares

et al. 2015

Intern J of Cosmetic Sci

108

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“…Vaginal dosage forms have a short residence time at the place where the drug is applied, therefore, for its control as well as determination of fixation degree the rates of distribution and adhesion have been determined [7,8].…”

Section: Objects and Methodsmentioning

confidence: 99%

Determination of the Bioadhesion Indicators of Vaginal Gel With Resveratrol and Hyaluronic Acid

Іванюк

Yarnykh

Kovalevska

2019

EUREKA: Health Sciences

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Aim. The purpose of the work is to determine the bioadhesion indices of vaginal gel with resveratrol and hyaluronic acid, as well as the choice of the type and content of mucoadhesives in the composition. Materials and methods. As research objects samples of gels with different mucoadhesives in the composition were used. Among used mucoadhesives were: sodium alginate (FMC BioPolimer AS, Norway), methyl cellulose (Shin Etsu, Germany), Methocel – methyl cellulose with hydroxypropylmethyl cellulose (Dow Pharmaceutical Sciences, USA), OraRez® W-100L16 – vinyl methyl ether and maleic anhydride copolymer (BOAI, China). As a comparison drug, vaginal gel "Gynodec" (Yuriya-Pharm) was used. During the study, the rate of gel distribution, the degree of deformation under the influence of mechanical forces, the degree of the gel fixation on the surface of the mucosa and the adhesion ability of the samples have been determined. Results. The study has determined that sample No. 2 with sodium alginate has the highest distribution rate, which was 1.56 cm/min. The study of the fixation of samples on the surface of the model of the mucous was performed by the method of flow. The results have showed that the sample with sodium alginate has the closest value to the reference drug. The adhesive ability of samples with different sodium alginate contents was determined. The tensimetric study has found that at a concentration of 0.5 %, the force required to separate the surface is 6158 Pa. Conclusions. On the basis of the complex of physico-chemical studies, bioadhesion indicators of vaginal gel with resveratrol, depending on the type and concentration of mucoadhesives have been determined. According to the distribution parameters on the surface of the genital mucosa model, it has been found that the best properties compared with other types of mucoadhesives has a sample containing sodium alginate. The study by means of a strain gauge has found that the addition of sodium alginate at a concentration of 0.5 % would provide a satisfactory adhesive ability of the vaginal gel.

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“…This indicates the force of the interaction between hydrogel and the mucin. ∆F max values of formulations containing Satiaxane ® , F8, F9, F15 and F16, were higher than those without [45], ophthalmic hydrogel [46] or vaginal hydrogel [47]. As a natural biocompatible polymer, xanthan gum has a β-(1→4)-D-glucose backbone where every second glucose unit is attached to a trisaccharide consisting of mannose, glucuronic acid, and mannose.…”

Section: In Vitro Mucoadhesion Measurement Using Tensile Testmentioning

confidence: 99%

Cyanine derivative as a suitable marker for thermosensitive in situ gelling delivery systems: In vitro and in vivo validation of a sustained buccal drug delivery

Zeng

Séguin

Destruel

et al. 2017

International Journal of Pharmaceutics

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Buccal administration route is a promising way for a large number of drugs exhibiting a low oral bioavailability. The present work describes the formulation and evaluation of a mucoadhesive and thermosensitive in situ gelling delivery system based on poloxamer 407, poloxamer 188 and xanthan gum for buccal drug delivery. First, the mucoadhesion properties were evaluated using a tensile test. The effect of xanthan gum on the mucoadhesion force was demonstrated. Then, to assess the buccal residence time which reflects the mucoadhesion properties, the validation of a fluorescence probe for in vivo optical imaging experiment was conducted. Methyl-Cyanine 5 derivative (Me-Cy5) was used to label the hydrogels, dissolution tests and permeation studies through buccal epithelium cells showed that Me-Cy5 release from hydrogels was mainly due to an erosion mechanism and presented a limited penetration across epithelium cells. These results suggest that, Me-Cy5 is a suitable marker for thermosensitive in situ gelling delivery systems as the probe mostly stays entrapped in the hydrogel and do not cross the epithelial barrier. Buccal residence performance of the hydrogel was evaluated for the first time by non-invasive optical imaging after administration to mice. This technique is an interesting alternative compared to visual observations and sacrifice involved experiments, which could also be exploited to various administration routes.

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Screening of mucoadhesive vaginal gel formulations

Cited by 24 publications

References 28 publications

Bioadhesive hydrogels for cosmetic applications

Bioadhesive hydrogels for cosmetic applications

Determination of the Bioadhesion Indicators of Vaginal Gel With Resveratrol and Hyaluronic Acid

Cyanine derivative as a suitable marker for thermosensitive in situ gelling delivery systems: In vitro and in vivo validation of a sustained buccal drug delivery

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