Analgesic and anti-inflammatory activities of several 4-substituted-6-(3'-nitrophenyl)pyridazin-(2H)-3-one derivatives

Singh, Anita; Lakshmayya,; Asif, Mohammad

doi:10.1590/s1984-82502013000400030

Cited by 16 publications

(6 citation statements)

References 18 publications

(13 reference statements)

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“…In recent years substituted pyridazinones have been a subject of demanding research due to their wide range of pharmacological actions 22,24 . Differently substituted pyridazinone derivatives were exhibited diverse potential pharmacological activities like an antidepressant, antihypertensive, anti-thrombotic, anticonvulsant, cardiotonic, analgesic, antiinflammatory, diuretics, antibacterial, anti-fungal, antiviral, anticancer, hypotensive, antiulcer and another biological activities 25,29 . (2H)-one (0.001 mol) in methanol (30 mL) was added formaldehyde (37-41%) (2.5 mL) and the contents were refluxed for 6 h. After completion of the reaction methanol was distilled off and the residue was poured into crushed ice to separate out the compound.…”

Section: Methodsmentioning

confidence: 99%

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2022

IJPSR

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The main objective presents research work to synthesize, characterization, and in-vivo evaluation of Pyridazine derivatives. To study the different synthesized derivatives by using different analytical parameters like IR, Mass, and NMR analysis. And also find out the antihypertensive activity. The studies on the hydralazine group drugs led to the synthesis of many Pyridazine derivatives with a wide activity spectrum on the cardiovascular system. Pyridazine derivatives, a class of compounds containing the N-N bond, exhibit a wide range of pharmacological activities such as antidepressant, antihypertensive and cardiotonic etc. Some 7-phenyl-3, 4, 8, 9-tetrahydro-2H-pyridazino [1, 6-a] [1, 3, 5] triazin-2-imine were synthesized by reacting 6-Phenyl substituted 2, 3, 4, 5-Tetrahydro pyridazin-3-one with cyclic secondary amine under Mannich reaction conditions. The total seven compounds (vj1-vj7) were synthesized under Mannich reaction conditions. All the synthesized derivatives were selected for evaluation of antihypertensive activities by a noninvasive method using Tail Cuff method. Most of the compounds showed good antihypertensive activity. Few compounds like vj4, vj5, and vj6 were found to show a highly significant reduction in mean arterial blood pressure but at a higher dose in comparison to standard drugs like proponolol and hydralazine. The substituted pyridazine derivatives discovered in this study may provide valuable therapeutic intervention for the treatment of hypertension. INTRODUCTION:In the present scenario, a large number of medications acting through different mechanisms for the treatment of hypertension are available.

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Section: Methodsmentioning

confidence: 99%

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2022

IJPSR

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“…Results showed that furfurylidene derivative 35 was more potent for in vivo anti-inflammatory activity than other substituted benzylidene derivatives (Figure 24). [62] Moreover, compound 35 showed 40% inhibition of edema compared to indomethacin (44.53% inhibition of edema).…”

Section: Anti-inflammatory Activity Of 26-disubstituted Pyridazinonesmentioning

confidence: 97%

Anti‐inflammatory activity of pyridazinones: A review

Hassan

Ahmed

El‐Malah

et al. 2022

Archiv der Pharmazie

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The pyridazinone core has emerged as a leading structure for fighting inflammation, with low ulcerogenic effects. Moreover, easy functionalization of various ring positions of the pyridazinone core structure makes it an attractive synthetic and therapeutic target for the design and synthesis of anti-inflammatory agents. The present review surveys the recent advances of pyridazinone derivatives as potential anti-inflammatory agents to provide insights into the rational design of more effective anti-inflammatory pyridazinones.

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“…The compounds (1-8) showed mild to moderate anticonvulsant activity ranging from 0.0% to 50% in Table 3. Indomethacin was taken as standard drug [31][32][33] . Table 4.…”

Section: Anti-convulsant Activitymentioning

confidence: 99%

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2020

IJPSR

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Arylpropionic acid derivatives are an important class of NSAIDs. Ibuprofen, 2-(4-isobutylphenyl) propionic acid, is known as NSAIDs. Arylpropionic acid derivatives have a broad biological activity, including antibacterial, anticonvulsant and anticancer activity, analgesic, and anti-inflammatory. In addition to the most powerful ingredients used in analgesic and antipyretic fields, such as ibuprofen, Oxaprozin, Ketoprofen, and Phenoprofen, aryl propionic acid derivatives play an important role in treating other symptoms. The possible improvements in the activity can be further achieved by slight modifications in the substituent on the basic aryl propionic acid. According to Grigoryan et al., 2019 studies reveal that the replacement of the carboxyl group by tetrazole ring, hydroxamate, ester, alcohol, and amide groups forms compound showing lower activity (antiinflammatory, anti-nociceptive, ulcerogenic activity). The presence of a carboxyl group in the parent molecule of aryl propionic acid is important for broad-spectrum pharmacological activity. This review focused on recent advances and recent research on aryl propionic acid derivatives compared to medicinal chemistry. INTRODUCTION: Medical chemistry is an area that determines the effect of chemical composition on biological activity. Medical chemistry has been expanded with the help of experimental methods for predicting the composition of new compounds that rely heavily on structural changes and the determination of biological properties.

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Analgesic and anti-inflammatory activities of several 4-substituted-6-(3'-nitrophenyl)pyridazin-(2H)-3-one derivatives

Cited by 16 publications

References 18 publications

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Anti‐inflammatory activity of pyridazinones: A review

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