Anti‐inflammatory activity of pyridazinones: A review

Abstract

The pyridazinone core has emerged as a leading structure for fighting inflammation, with low ulcerogenic effects. Moreover, easy functionalization of various ring positions of the pyridazinone core structure makes it an attractive synthetic and therapeutic target for the design and synthesis of anti-inflammatory agents. The present review surveys the recent advances of pyridazinone derivatives as potential anti-inflammatory agents to provide insights into the rational design of more effective anti-inflammatory pyridazinones.

Small Molecules as Anti‐inflammatory Agents: Molecular Mechanisms and Heterocycles as Inhibitors of Signaling Pathways

“…Also, focussing on the more recent report of miscellaneous heterocycles as anti-inflammatory agents ChemistrySelect compare to previous review articles that cover the literature until 2021. [110][111][112][113]…”

“…The present review provides comprehensive information on the anti‐inflammatory activity of pyrazole, pyrimidines, pyrrole, and indole. Also, focussing on the more recent report of miscellaneous heterocycles as anti‐inflammatory agents compare to previous review articles that cover the literature until 2021 [110–113] …”

Discovery of a new pyrido[2,3-d]pyridazine-2,8-dione derivative as a potential anti-inflammatory agent through COX-1/COX-2 dual inhibition

“…8 Furthermore, pyridazinebased compounds have been widely evaluated as antiinflammatory agents, highlighting the importance of this nitrogen-heterocycle in anti-inflammatory drug discovery. 9 Recently, we reported the synthesis and anti-inflammatory activity of 3,5,6-trisubstituted 2-pyridone derivatives I, where one of the most active compounds was identified as a selective COX-2 inhibitor. 10 Herein, we envisioned the generation of a new bicyclic fused scaffold by cyclization of I with hydrazines and investigated their anti-inflammatory activity (Fig.…”

“…8 Furthermore, pyridazine-based compounds have been widely evaluated as anti-inflammatory agents, highlighting the importance of this nitrogen-heterocycle in anti-inflammatory drug discovery. 9…”

Pyridazine derivatives as selective COX‐2 inhibitors: A review on recent updates

“…Based on the results of the survey, and as a continuation of our research into the synthesis and biological evaluation of pyridazines (Hassan et al, 2022), we aimed to prepare a review to introduce pyridazines as selective COX‐2 inhibitors.…”