Phenolic compounds and antioxidant, antimicrobial and antimycobacterial activities of Serjania erecta Radlk. (Sapindaceae)

Abstract

Serjania erecta Radlk.(Sapindaceae) is a medicinal plant traditionally used in Brazil. We assayed the ethanolic extract of leaves and roots against seven microorganisms. The REMA (Resazurin Microtiter Assay) assay was used to measure the biological activity in vitro against Mycobacterium tuberculosis and our results showed moderate activity of the ethanolic extract. On the other hand S. aureus, P. aeruginosa, S. setubal, C. albicans, S. cerevisiae and E. coli revealed that the leaves and roots of S. erecta inhibited the growth of all microorganisms. The ethanolic extracts of leaves and roots showed low values of antioxidant activities. The ethanolic extracts of leaves and roots were analyzed by chromatographic and spectrometric methods. (-)-Epicatechin, kaempferol aglycone and five glycoside derivates wereglucopyranoside from the roots and kaempferol, kaempferol 3,7-di-O-a-L-rhamnopyranoside, vitexin, isovitexin and (-)-epicatechin in the leaves. This is the first chemical study reported in the literature about this specie. Uniterms: Serjania erecta

Unusual C,O-Fused Glycosylapigenins from Serjania marginata Leaves

“…Only the flavonoid C-glucosides, vitexin, and isovitexin have been described previously for the Serjania genus. 4 In the work described here, cassiaoccidentalin A (2), tetrastigma B (3),…”

Bioactivity and Molecular Docking Studies of Derivatives from Cinnamic and Benzoic Acids

“…Phenolic compounds comprise a broad class of secondary metabolites that possess a large spectrum of biological properties [9][10][11][12], and they have been successfully investigated for the treatment of systemic and superficial mycoses caused by different human pathogenic fungi [13][14][15][16][17]. Benzoic and cinnamic acids and their derivatives play an important role in antifungal activity, and several studies have focused on this bioactivity [18][19][20][21][22][23][24][25].…”

A New Glycoside and in vitro Evalution of α-Glucosidase Inhibitory Activity of Constituents of the Mangrove Lumnitzera racemosa

“…The chemical investigation on the L. racemosa leaves collected at Kien Giang province, Viet Nam led to the isolation of ten compounds including the new one (1) by the use of efficient separation techniques ( Figure 1). The known compounds were identified as myricetin (2) [6] [10], gallic acid (8) [11], kaempferol (9) [12] and (3S,5R,6S,7E)-3,5,6trihydroxy-7-megastigmen-9-one (10) [13] via spectroscopic data analysis and comparison with those reported in the literature. In the 1 H NMR spectrum, the two anomeric proton signals at δ H 4.89 (a broad singlet, H-1) and 4.84 (a doublet, J = 1.0 Hz, H-1) showed that the two 1-OH and 1-OH groups were at the axial positions.…”