Effect of Ficus hispida L. on normal and dexamethasone suppressed wound healing

Murti, Krishna; Lambole, Vijay; Panchal, Mayank

doi:10.1590/s1984-82502011000400023

Cited by 16 publications

(15 citation statements)

References 14 publications

(10 reference statements)

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“…The effective and diverse compounds in the Verbascum plant species such as avonoids, polysaccharides, tannins, saponins, verbacosides, steroids, carbohydrates, and anti-in ammatory and antimicrobial properties are important factors in the regeneration of dermis [20,25,31,32]. As the results of the extraction of the Verbascum chemical compounds in our study showed, one of the most abundant compounds of this plant is the avonoid, which is consistent with the results of other studies [21,39].…”

Section: Discussionsupporting

confidence: 90%

“…Toxic effects of this plant have not been reported in any of the studies [25,29]. In the research conducted, the Toxic effects of this plant have not been seen [25,29,31,32]. Besides, the traditional use of Mullein as herbal medicine is described in the EMA Pharmaceutical Monograph [33].…”

Section: Introductionmentioning

confidence: 99%

“…The chemical structure of the Verbascum contains substances such as tannins, alkaloids, and saponins, polysaccharides, and avonoids, each of which can be responsible for wound healing activities [31]. The avonoids and polysaccharides in this plant cause the proliferation of broblasts and connective tissue, which causes a signi cant effect of the Verbascum in the process of healing incisional and excisional wounds [20].…”

Section: Introductionmentioning

confidence: 99%

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The Effect of the Verbascum Thapsus on Episiotomy Wound Healing in Nulliparous Women: A Randomized Controlled Trial

Taleb

Saeedi

2021

Preprint

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Background: The pain and discomfort caused by episiotomy affect the quality of life of the mothers, so rapid and complete repair of the episiotomy is very important. Due to the effective ingredients of Verbascum Thapsus, it has been used since ancient times to treat wounds. Therefore, the aim of this study was to evaluate the effect of Verbascum Thapsus on episiotomy wound healing. Methods: The study was designed as a randomized, double-blind, controlled clinical trial. Ninety-three primiparous women who referred to Fatemeh Zahra Hospital in Saveh in 2015 were randomly divided into two groups of intervention (Verbascum Thapsus) and control (placebo). Both groups covered the episiotomy wound twice a day for 10 days with 2 cm of prescribed creams. Wound healing was assessed using the REEDA scale before the intervention and on days 1,3 and 10 after the intervention.Results: Before the intervention, there was no statistically significant difference in terms of demographic characteristics, obstetrics and REEDA scores between the two groups (p <0.05). The mean scores of REEDA on days 1 and 3 in the intervention group was better than the control group but was not statistically significant. However, on the tenth day after the intervention, the mean scores of REEDA were significantly better in the Verbascum group than the placebo (p = 0.01). Conclusions: According to the results of this study, it seems that Verbascum Thapsus is effective in repairing episiotomy wounds. The researchers hope that the results of this study can provide the clinical evidence for the use of this herbal medicine in the wound healing process. Trial registration: this study was registered in the Iranian Registry of Clinical Trials (IRCT) with the code “IRCT201404073106N15” on 02/12/2015

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Section: Discussionsupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The Effect of the Verbascum Thapsus on Episiotomy Wound Healing in Nulliparous Women: A Randomized Controlled Trial

Taleb

Saeedi

2021

Preprint

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“…Beberapa penelitian ilmiah telah menggali manfaat luwingan sebagai bahan obat, namun masih terbatas pada daun, batang, kulit pohon, dan akar (Mandal & Kumar, 2002;Lansky & Paavileinen, 2011;Murti et al, 2011). Informasi mengenai pemanfaatan buahnya masih terbatas (Shahreen et al, 2012).…”

Section: Pendahuluanunclassified

UJI TOKSISITAS ORAL AKUT SINGLE DOSE FILTRAT BUAH LUWINGAN (Ficus hispida L.f.) PADA TIKUS (Rattus norvegicus Berkenhout, 1769) GALUR WISTAR

Fitria

2019

mangiferaedu

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Genus Ficus is important plant for health benefits. Hairy fig (F. hispida) trees grow abundantly in tropical regions and fruiting throughout the year. In West Asian countries, the fruit is commonly used as food and medicinal materials. However, in Indonesia, the fruit has not been utilized. First step in exploring the potential of natural resources for consumption is toxicity test to provide information about safety and adverse effects. This research was aimed to study acute oral toxicity of young and ripe hairy fig fruits using Wistar rats as model. Procedure followed OECD Guideline Test No.420 with modification. Pure filtrate (100 %) of young or ripe fruits were administered orally at volume 1 mL/individual on day-0 in fasting animals. Control received distilled water in the same way. Parameters observed including mortality, sublethal effects, behavior/activities, body weight, complete blood count, as well as evaluation of liver, heart, and renal functions. Results showed that values for all variables fluctuated during the experiment but eventually back into normal range. However, the number of lymphocytes elevated until the end of experiment (day-14) thus increased the total leukocytes count. Accordingly, we are preparing to conduct further toxicity tests to investigate this finding. Key words : acute oral toxicity, Ficus hispida, fruit filtrate, hairy fig, single dose toxicity

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“…)(Moraceae)Ethanolic extract of roots of F. hispida was investigated in normal and dexamethasone depressed healing conditions, using incision, excision and dead space wound models in albino rats. Collagen and hydroxyproline content was increased thus proving the pro-healing effect of the plant[40] 27. Pyrus communis (Rosaceae) Ethanol and ethyl acetate extracts of P. communis were tested in dexamethasone delayed wound healing model in rats.…”

mentioning

confidence: 92%

Alternative Approaches to Wound Healing

Majumdar¹,

Sangole²

2016

Wound Healing - New Insights Into Ancient Challenges

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The history of wound healing across the globe abounds with usage of various herbs for treating simple cuts and bruises to serious burns. Wound healing is a complex and dynamic process and, moreover, depends a lot on the wound bearing person's immunity and mental status. Synthetic medicine may give rise to side effects of allergy and resistance with usually higher cost of treatment. Whereas the alternative and complementary medicine such as Ayurveda, Siddha, Unani, Chinese medicine, and ozone therapy can lessen these side effects considerably and offer treatment at lower costs, thus elevating the overall quality of life of the patient. In today's times the patient is more demanding and has the ability to partake in treatment decisions. It is then the moral responsibility of the scientists to apply modern up-to-date scientific acumen to provide evidenced-based concept to alternative therapies of wound healing to ensure that these practices are safe and efficacious.

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Effect of Ficus hispida L. on normal and dexamethasone suppressed wound healing

Cited by 16 publications

References 14 publications

The Effect of the Verbascum Thapsus on Episiotomy Wound Healing in Nulliparous Women: A Randomized Controlled Trial

The Effect of the Verbascum Thapsus on Episiotomy Wound Healing in Nulliparous Women: A Randomized Controlled Trial

UJI TOKSISITAS ORAL AKUT SINGLE DOSE FILTRAT BUAH LUWINGAN (Ficus hispida L.f.) PADA TIKUS (Rattus norvegicus Berkenhout, 1769) GALUR WISTAR

Alternative Approaches to Wound Healing

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