Efficacy of a commercial fungal formulation containing Duddingtonia flagrans (Bioverm®) for controlling bovine gastrointestinal nematodes

Rodrigues, Jossiara Abrante; Roque, Francisco Leonardo; Alvares, Felipe Boniedj Ventura; Silva, Ana Luzia Peixoto; Lima, Estefany Ferreira; Filho, Geraldo Moreira da Silva; Feitosa, Thaís Ferreira; Araújo, Jackson Víctor de; Braga, Fábio Ribeiro; Vilela, Vinícius Longo Ribeiro

doi:10.1590/s1984-29612021025

Cited by 11 publications

(4 citation statements)

References 19 publications

(19 reference statements)

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“…To date, D. flagrans has been viewed as a good controller of trichostrongylides and cyathostome (the most prevalent GINs in livestock) in various domestic animals (Table 1). Bioverm®, a fungal formulation that contains chlamydospores of D. flagrans, has been licensed for commercialization in Brazil [17,47].…”

Section: Duddingtoniamentioning

confidence: 99%

Individual and Combined Application of Nematophagous Fungi as Biological Control Agents against Gastrointestinal Nematodes in Domestic Animals

Gong

et al. 2022

Pathogens

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Gastrointestinal nematodes (GINs) are a group of parasites that threaten livestock yields, and the consequent economic losses have led to major concern in the agricultural industry worldwide. The high frequency of anthelmintic resistance amongst GINs has prompted the search for sustainable alternatives. Recently, a substantial number of both in vitro and in vivo experiments have shown that biological controls based on predatory fungi and ovicidal fungi are the most promising alternatives to chemical controls. In this respect, the morphological characteristics of the most representative species of these two large groups of fungi, their nematicidal activity and mechanisms of action against GINs, have been increasingly studied. Given the limitation of the independent use of a single nematophagous fungus (NF), combined applications which combine multiple fungi, or fungi and chemical controls, have become increasingly popular, although these new strategies still have antagonistic effects on the candidates. In this review, we summarize both the advantages and disadvantages of the individual fungi and the combined applications identified to date to minimize recurring infections or to disrupt the life cycle of GINs. The need to discover novel and high-efficiency nematicidal isolates and the application of our understanding to the appropriate selection of associated applications are discussed.

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Section: Duddingtoniamentioning

confidence: 99%

Individual and Combined Application of Nematophagous Fungi as Biological Control Agents against Gastrointestinal Nematodes in Domestic Animals

Gong

et al. 2022

Pathogens

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“…In the last five years, commercial formulations containing D. flagrans started became commercially available. In Brazil (Bioverm ® -AC001, GhenVet Saúde Animal, Paulínia, Brazil), Australia, and New Zealand (BioWorma ® -NCIMB 30336, BioWorma, Sydney, Australia), these products are already used, with administration in animal feed [8,[11][12][13][14].…”

Section: Brief History Of Helminthophagous Fungimentioning

confidence: 99%

“…It has been proven that after oral administration of D. flagrans (AC001-Bioverm ® , GhenVet Saúde Animal, Paulínia, Brazil), at a dosage of 1 g/10 kg of body weight (10 5 chlamydospores/g), there was fungal survival after passage through the gastrointestinal tract of sheep and cattle, with efficient larval predation in vitro [8,14]. Under field conditions, the daily administration of Bioverm ® for six months demonstrated a significant parasitic reduction in cattle and horses in Brazil [12,13].…”

Section: Advances In the Control Of Gastrointestinal Nematodes In Pasture Animalsmentioning

confidence: 99%

Recent Advances in the Control of Helminths of Domestic Animals by Helminthophagous Fungi

et al. 2021

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This review describes the advances acquired and proven in the use of helminthophagous fungi in the control of gastrointestinal helminth parasites in domestic animals. Old and well-known premises about parasitic epidemiology and the factors that can interfere with the best performance of biological control are mentioned. Some of the most promising fungi are Duddingtonia flagrans from the predatory fungi group and Pochonia chamydosporia and Mucor circinelloides from the ovicidal fungi group. These fungi produce resistance spores called chlamidospores. Bioverm® and BioWorma®, based on the fungus D. flagrans, are available as commercial. Biotechnological products such as nanoparticles and obtaining primary and secondary metabolites have already been obtained from these fungi. Because they have different mechanisms of action, ovicidal and predatory fungi, when used together, can present a complementary and synergistic action in the biological control of helminths. Therefore, future research in the search for new formulations, the association of fungi from different groups, extraction of new molecules, and nanoparticles of these fungi in the control of helminths in various domestic animals are desired.

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“…In Brazil, there is a commercially available product based on the fungus D. agrans (Bioverm®). The effectiveness (in vitro) of Bioverm® was reported against gastrointestinal nematodes of different animal species, such as horses (Fausto et al, 2021); sheep (Braga et al, 2020) and cattle (Rodrigues et al, 2021). Among cattle, the e cacy of the product for controlling verminosis in the eld, in the central-western region, has also been described (Oliveira et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

Control of sheep gastrointestinal nematodes on pasture in the tropical semiarid region of Brazil, using Bioverm® (Duddingtonia flagrans)

Rodrigues

Roque

Lima

et al. 2022

Trop Anim Health Prod

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We aimed to evaluate a Brazilian commercial formulation of the fungus Duddingtonia agrans (Bioverm®) for controlling gastrointestinal nematodes in sheep kept on native pasture in the Caatinga biome, in the semiarid region of Brazil. Twenty ewes, aged between 12 and 18 months, were divided into two groups. In the treated group, each animal received 1 g of the Bioverm® product for each 10 kg of live weight, daily, together with commercial feed, for six months. In the control group, the animals received feed without Bioverm®. Each group remained throughout the experiment in a 1.2 ha paddock. Monthly counts of eggs per gram of feces (EPG), fecal cultures, packed cell volume (PCV), weight measurements and collection of leaf mass from the pasture were performed. There was greater reduction in EPG, greater weight gain and less infestation by infective larvae in the paddock of the Bioverm® group, compared with the control group (p < 0.05). There was no signi cant difference (p ≥ 0.05) in the mean PCV percentage between the Bioverm® and control groups. In coprocultures, Haemonchus sp. was the most prevalent helminth. Bioverm® (D. agrans) was e cient for biological control of sheep gastrointestinal nematodes in the semiarid region of Brazil.

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Efficacy of a commercial fungal formulation containing Duddingtonia flagrans (Bioverm®) for controlling bovine gastrointestinal nematodes

Cited by 11 publications

References 19 publications

Individual and Combined Application of Nematophagous Fungi as Biological Control Agents against Gastrointestinal Nematodes in Domestic Animals

Individual and Combined Application of Nematophagous Fungi as Biological Control Agents against Gastrointestinal Nematodes in Domestic Animals

Recent Advances in the Control of Helminths of Domestic Animals by Helminthophagous Fungi

Control of sheep gastrointestinal nematodes on pasture in the tropical semiarid region of Brazil, using Bioverm® (Duddingtonia flagrans)

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