Hematological changes associated with hemoplasma infection in cats in Rio de Janeiro, Brazil

Raimundo, Juliana Macedo; Guimarães, Andresa; Botelho, Camila Flávia Magalhães; Peixoto, Maristela Peckel; Pires, Marcus Sandes; Machado, Carlos Henrique; Santos, Huarrisson Azevedo; Massard, Carlos Luiz; André, Marcos Rogério; Machado, Rosangela Zacarias; Baldani, Cristiane Divan

doi:10.1590/s1984-29612016086

Cited by 12 publications

(15 citation statements)

References 30 publications

(58 reference statements)

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“…Thrombocytopenia (86%) and anaemia (40%) were the most common haematological signs in the current study. Our results are in line with the results of Raimundo et al (2016), who determined the most common hematological findings as anaemia and thrombocytopenia. Thrombocytopenia may be due to the destruction and consumption of platelets, increased hepatic or splenic platelet sequestration, decreased platelet production following bone marrow hypoplasia, and production of antiplatelet antibodies.…”

Section: Discussionsupporting

confidence: 92%

Response to doxycycline and oxytetracycline treatments in cats infected with Mycoplasma spp. and analysis of haemato-clinical findings and risk factors

Çetin¹,

Ekici

Küçükyildiz

et al. 2021

Trop Biomed

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This study was planned to determine the efficacy of doxycycline and oxytetracycline in the treatment of feline Mycoplasma spp. infections and to analyze risk factors as well as clinical and haematological findings. Cats accepted to the clinic with complaints such as weakness, loss of appetite and fever were routinely examined. Clinical history of animal was demanded from the owner. An interview and a short questionnaire were conducted to owner to evaluate the risk factors associated with possible Mycoplasma status of animal. During the interview, the age, sex, breed, housing, flea infestation, worm control, external parasite control, other accompanying infections and vaccination status of cats were asked and the data recorded. Peripheral blood smears were stained with the DIFF-QUICK. Fifty positive cats were included in the study, 16 of which were treated with doxycycline (orally, 5 mg/kg twice a day) while other 34 with oxytetracycline (intramuscular injection, 10 mg/kg once a day). It was determined that all (100%) cats with Mycoplasma spp. infection had a flea infestation. Majority of cats (94%) did not receive the regular antiparasitic application and only 6 (12%) of them had complete vaccinations. Mycoplasma spp. infection was associated with younger age and outdoor access. Among the feline breed, striped cat (74%) was more prone to infection. The most common clinical signs encountered in cats were weakness (94%) and anorexia (84%). Haematological parameters revealed thrombocytopenia (86%), and anaemia (40%) in infected cats. At the end of the treatment, recovery rates for doxycycline and oxytetracycline groups were 87.5% and 67.6%, respectively. General status of these cats indicated significant improvement on the 4 th day of treatment, and clinical symptoms are restored on the 7 th day. Mycoplasmosis is an important infection for cats having anaemia, thrombocytopenia and leukocytosis. Flea infestations are risk factor for contamination of the disease. Based on our results, we recommend doxycycline treatment (5 mg/kg) for up to 21 days for elimination of Mycoplasma spp. in the blood of infected cats.

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Section: Discussionsupporting

confidence: 92%

Response to doxycycline and oxytetracycline treatments in cats infected with Mycoplasma spp. and analysis of haemato-clinical findings and risk factors

Çetin¹,

Ekici

Küçükyildiz

et al. 2021

Trop Biomed

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“…M. turicensis’ or ‘ Ca . M. haemominutum’ alone 41 . Macroscopic examination of one pig in the present case revealed similar results as observed after infection with M suis (icterus, ascites, liver alterations, pale mucus membranes) 42 .…”

Section: Discussionsupporting

confidence: 85%

Detection of a novel haemoplasma species in fattening pigs with skin alterations, fever and anaemia

Stadler¹,

Ade

Ritzmann³

et al. 2020

Veterinary Record

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BackgroundIn a fattening farm in Southern Germany, skin alterations (urticaria, haemorrhagic diathesis) and high fever were observed in 30% of the pigs 2 weeks after arrival. Feed intake was severely compromised in affected pigs.MethodsAfter detailed clinical observation, blood samples from affected pigs were collected for haematological, PCR and serological investigations. In addition, pathological investigations were performed on one pig.Results and conclusionAnalysis of blood parameters revealed a normocytic, normochromic anaemia. A novel porcine haemoplasma species was detected in blood samples of affected pigs and spleen sample of the necropsied pig by PCR. Phylogenetic analyses based on the 16S rDNA showed 99% identity to a novel porcine haemoplasma (‘Candidatus (Ca.) M. haemosuis’) species which has recently been described in China. Interestingly, this is the first report of ‘Ca. M. haemosuis’ in pigs with clinical signs resembling those of Mycoplasma (M) suis and the first description of this novel haemoplasma species outside Asia. On-farm affected pigs were treated with oxytetracycline and non-steroidal anti-inflammatory drugs. Clinical signs improved after implementation of treatment and optimisation of management procedures. This case might indicate that other porcine haemoplasma species than M suis can induce fever and skin alterations and may have an economic impact on affected farms.

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“…Co-positivity for the different species of hemoplasma has been described in felines, mainly among the most prevalent species in the region, and tends to prevail in male felines (SANTOS et al, 2014;DUARTE et al, 2015), as also found in this study. Male felines may be at increased risk for hemoplasma infection due to frequent fights over territory disputes and females in estrus (JENKINS et al, 2013;RAIMUNDO et al, 2016). Although the association of Mhm infection with anemia has already been described in other studies (SANTOS et al, 2014), in this study no association with anemia was observed by any of the investigated agents, although the feline population came from a veterinary hospital similar to the studies of Aquino et al (2014), Spada et al (2014), andVergara et al (2016).…”

Section: Introductionsupporting

confidence: 55%

Natural hemoplasma infection of cats in Cuiaba, Mato Grosso, Brazil

Makino

Paula

Sousa

et al. 2018

SCA

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The aim of this research was to investigate natural hemoplasma infection in cats treated at the Veterinary Hospital of the Federal University of Mato Grosso, and the factors associated with infection. Blood samples from 151 cats of different sexes, breeds, and ages were analyzed by PCR and blood count. The overall occurrence of hemoplasma was 25.8%. Mycoplasma haemofelis (Mhf), ‘Candidatus Mycoplasma haemominutum (CMhm)’, and ‘Candidatus Mycoplasma turicensis’ (CMt) were observed in 15.2%, 14.6% and 2.6% of cats, respectively. In 6.6 % of cases, co-infection was observed. Male felines or mixed breed cats were associated with infection by CMhm (P = 0.02 and 0.04, respectively). The data obtained demonstrated an occurrence of 25.8% for hemoplasma infection in felines coming from clinical care in the city of Cuiabá, where males were at higher risk of acquiring the infection by these agents, in addition to a higher risk for CMhm in felines with no specific breed.

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Hematological changes associated with hemoplasma infection in cats in Rio de Janeiro, Brazil

Cited by 12 publications

References 30 publications

Response to doxycycline and oxytetracycline treatments in cats infected with Mycoplasma spp. and analysis of haemato-clinical findings and risk factors

Response to doxycycline and oxytetracycline treatments in cats infected with Mycoplasma spp. and analysis of haemato-clinical findings and risk factors

Detection of a novel haemoplasma species in fattening pigs with skin alterations, fever and anaemia

Natural hemoplasma infection of cats in Cuiaba, Mato Grosso, Brazil

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