Acute effects of Resistance exercise performed on ladder on energy metabolism, stress, and muscle damage in rats

Silvestre, João Guilherme; Speretta, Guilherme Fleury Fina; Fabrizzi, Fernando; Moraes, Gilberto; Duarte, Ana Cláudia Garcia de Oliveira

doi:10.1590/s1980-6574201700si0010

Cited by 5 publications

(2 citation statements)

References 43 publications

(59 reference statements)

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“…Recent research has shown that resistance exercises have different benefits in the patients. Even more, in some studies, the superiority of resistance training over aerobics training has been proven; resistance training reduces HbA1c, lipid volume and systolic blood pressure 15,26,27. However, in this study, by using EPN exercises and focusing on the lower extremities of the patients, in addition to the benefits of resistance training in the patients, we could significantly decrease the serum levels of TNF-α and CRP in them, ultimately leading to improving the sensation of pain and tingling in the patients.…”

Section: Discussionmentioning

confidence: 99%

<p>Comparison of the effect of two therapeutic exercises on the inflammatory and physiological conditions and complications of diabetic neuropathy in female patients</p>

Nadi

Bambaeichi

Marandi

2019

DMSO

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Introduction and aimThe purpose of this study was to compare the effect of 12 weeks of low-intensity resistance training and exercises for peripheral neuropathy (EPN) on the inflammatory and physiological conditions, balance, and complications of diabetic neuropathy in female patients.Materials and methods45 women with mild to moderate diabetic neuropathy and an average age of 55.46±3.06 years voluntarily participated in the study. They were randomly assigned to either control (n=15), resistance (n=15), and EPN (n=15) groups. Both experimental groups were trained for 12 weeks (three sessions per week). EPN group did peripheral neuropathic exercises (12 lower extremity movements), and the resistance group performed their exercises with a 30% repetition maximum. During the intervention period, the control group only performed their daily activities. Blood samples were taken in both pre-test and post-test to investigate the levels of Tumor necrosis-α (TNF-α), Interleukin-10 (IL-10), C Reactive Protein (CRP), fast blood glucose (FBG) and Glycated hemoglobin (HbA1c). Complications of diabetic neuropathy were measured using the Michigan questionnaire and the Monofilament 10 g. In order to measure the balance, De Morton mobility index (DEMMI) was used.ResultsThe statistical analyses showed a significant decrease of FBG and HbA1c in the two experimental groups, as compared to the control group. TNF-α and CRP levels were decreased in both EPN and resistance groups, as compared to the control group. The observed increase in the serum IL-10 levels of the two experimental groups was not, however, significant, as shown in intra-group and inter-group comparisons. On the other hand, the two complications of pain and tingling in the lower limb extremities were improved in both experimental groups (p<0.05). However, the numbness complication showed no significant change (p=0.10). Static and dynamic balance was improved in the EPN group as well (p<0.05).ConclusionSince EPN exercises, in contrast to resistance exercises, are focused on the lower limb extremities and designed for diabetic neuropathy patients, they can improve the imbalance, pain and tingling, by significantly reducing TNF-α and CRP and improving the physiological conditions.

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Section: Discussionmentioning

confidence: 99%

<p>Comparison of the effect of two therapeutic exercises on the inflammatory and physiological conditions and complications of diabetic neuropathy in female patients</p>

Nadi

Bambaeichi

Marandi

2019

DMSO

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“…Previous studies (Silvestre et al 2017;De Araujo et al, 2019;Santos et al 2020) have reported that high-intensity training can increase serum CK and LDH values and are used as parameter to assess physical effort intensity and muscle injuries. Regarding blood lactate concentrations, significant differences were found between the pre and post MCT moments in EX (p<0.0001) and AE (p<0.0001) groups, which results in relation to this metabolite are similar to those obtained by Silvestre et al (2017), who also performed an acute exercise session with a ladder model and progressive load increase.…”

Section: Discussionmentioning

confidence: 99%

High-Intensity Resistance Exercise and Schinus terenbinthifolius Supplementation Attenuate Oxidative Stress and Muscle Damage Biomarkers

et al. 2022

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High-intensity physical exercises can cause oxidative stress and muscle damage. Several medicinal plants have been used as antioxidant and anti-inflammatory agents. The present study evaluated high-intensity resistance exercise (HIRE) associated with Schinus Terebentifholius ethanolic extract (EE) on oxidative parameters and muscle damage in Wistar rats. Animals were divided into 04 groups (n=10/group): 1. Control (CG) -animals that did not undergo HIRE and were treated with vehicle (distilled water, orally); 2. Acute exercise (AE) -animals submitted to acute exercise session; 3. Exercise + vehicle (EV) -animals that underwent HIRE and were treated with vehicle and 4. Exercise + extract (EX) animals administered with Schinus terebenthifolius EE (100mg/Kg, orally) and submitted to the exercise session. Schinus terebenthifolius EE showed high in vitro antioxidant activity (13.88 ± 0.36 mg/mL). Before the experimental period, lactate was measured at pre and post moments of AE (p<0.0001) and EX (p<0.0001) groups. After the acute session, the following were evaluated: oxidative stress {malondialdehyde (MDA), sulfhydryl groups (SH) and ferric reducing antioxidant power (FRAP)}, muscle damage (creatine kinase (CK) and lactate dehydrogenase (LDH)), alanine aminotransferase (ALT) and aspartate aminotransferase (AST). In the in vivo analyses of the EX group compared to AE and EV groups, respectively: hepatic (MDA: p<0.0001 and SH: p=0.0033, in both; FRAP: p=0.0011 and p=0.0047), muscle (MDA, SH and FRAP: p<0.0001, in both; CK: p=0.0001 and p<0.0001; LDH: p<0.0001, in both), serum levels (MDA: p=0.0003, p=0.0012, SH: p=0.0056, p=0.0200, FRAP: p=0.0017 and p=0.0165) were significant. There was no significant difference in ALT and AST markers. It could be concluded that Schinus terebenthifolius EE associated with HIRE attenuated oxidative stress and muscle damage in rats.

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A Comprehensive Model of Blood Flow Restriction in the Post-surgical Rat

Fosam,

Ramos Nakandakari,

Ohashi

et al. 2024

Preprint

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Blood flow restriction (BFR) with low-load exercise (BFR-exercise) is an increasingly popular tool used to increase muscle strength and attenuate muscle atrophy, especially after injury or surgery. However, the mechanisms underlying BFR-mediated muscle growth are not well understood. Likely contributing to the mechanistic knowledge gap, rodent models of BFR-exercise have not been well described. In this methods paper, we demonstrate a comprehensive, clinically relevant protocol to establish BFR-exercise in awake rats. This protocol includes generating a muscle loss state via bilateral ACL-R, determining targeted blood flow occlusion pressures, and performing weighted hind-limb knee extension exercises with BFR. These methods can be used for further application in mechanistic and physiologic studies of BFR-exercise.

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Acute effects of Resistance exercise performed on ladder on energy metabolism, stress, and muscle damage in rats

Cited by 5 publications

References 43 publications

<p>Comparison of the effect of two therapeutic exercises on the inflammatory and physiological conditions and complications of diabetic neuropathy in female patients</p>

<p>Comparison of the effect of two therapeutic exercises on the inflammatory and physiological conditions and complications of diabetic neuropathy in female patients</p>

High-Intensity Resistance Exercise and Schinus terenbinthifolius Supplementation Attenuate Oxidative Stress and Muscle Damage Biomarkers

A Comprehensive Model of Blood Flow Restriction in the Post-surgical Rat

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