Ácido linoléico conjugado: efeitos no perfil lipídico e na composição corporal de camundongos exercitados

Abstract

Objetivo: Avaliar os efeitos do CLA associado à dieta hiperlipídica sobre o perfil lipídico e composição corporal de camundongos knockout para o gene da ApoE exercitados. Métodos: 32 camundongos foram divididos e submetidos à dieta normo e hiperlipídica suplementadas ou não com 1% de CLA. Todos realizaram exercício físico em esteira, durante 12 semanas. Utilizou-se o teste de Kruskal-Wallis ao nível de significância de 5%. Resultados: Os animais que ingeriram dieta hiperlipídica com CLA aumentaram o colesterol total e o LDL, comparado com os alimentados com dieta normolipídica associada ou não ao CLA. Observou-se aumento no ganho de peso dos camundongos que ingeriram dieta hiperlipídica com CLA, comparado com os normolipídicos suplementados com CLA. Conclusões: O CLA na concentração de 1% não alterou nenhum dos parâmetros analisados, independente da dieta, e não foi protetor contra os efeitos da dieta hiperlipídica.

Safflower Oil (Carthamus tinctorius L.) Intake Increases Total Cholesterol and LDL-cholesterol Levels in an Experimental Model of Metabolic Syndrome

“…Similar results were obtained by Fernandes et al,22 who demonstrated increase in cholesterol levels following supplementation with 1% of CLA. This fact can be explained by changes in hepatic lipid metabolism caused by CLA, which may affect metabolic interconversion of fatty acids in the liver, resulting in a modified composition of fatty acids, causing changes in lipoproteins.…”

“…[16][17][18][19][20][21] According to the results obtained in the second stage of the study, there was no statistically significant difference between the groups regarding weight gain, which is similar to the findings obtained in a study by Fernandes et al, 22 where no significant difference was found in the weight gain of animals in the groups given a diet supplemented with 1% of conjugated linoleic acid (CLA) compared to the groups that were not given the referred supplement. This finding is also corroborated by the study by Bhattachaya et al, 23 where BALB/C mice fed with a high-fat diet supplemented with 0.4% of CLA showed no change in body weight.…”

“…This fact can be explained by changes in hepatic lipid metabolism caused by CLA, which may affect metabolic interconversion of fatty acids in the liver, resulting in a modified composition of fatty acids, causing changes in lipoproteins. 24 Still regarding cholesterol, in the above-mentioned study by Fernandes et al 22 with animals supplemented with CLA distributed into active and sedentary, there was improvement in HDL-c levels in the sedentary group supplemented with CLA. However, in our study, as well as in the study by Marques et al, 25 which used safflower oil other than CLA, there was no statistically significant difference between the groups regarding HDL-c and serum triglycerides.…”