Orthokeratinized odontogenic cyst: a report of two cases in the mandible

Abstract

Purpose: To describe the behavior clinical and pathological features of two cases of odontogenic cyst orthokeratinized. Case description: In case 1, a 17-year-old woman presented hard and painless swelling in the left posterior mandible. Radiographically, a radiolucent area with a radiopaque was observed. A clinical diagnosis of ameloblastoma or odontogenic keratocystic tumor was established. The histopathological examination revealed an orthokeratinized odontogenic cyst. In case 2, a 23-year-old woman presented a radiolucent lesion surrounded by radiopaque halo symmetrically distributed on both partially erupted lower third molars. A clinical diagnosis of bilateral dentigerous cyst (DC) was rended. The histopathological examination showed bilateral orthokeratinized odontogenic cyst. Conclusion: Orthokeratinized odontogenic cyst should be considered in the differential diagnosis of lesions occurring in the jawbones associated with an impacted tooth, particularly those cases simulating dentigerous cyst. In addition, we observed the importance of radiographs taken prior to orthodontic treatment as an important tool in the diagnosis of oral pathologies. Performing routine radiograph is of high clinical value, especially before orthodontic treatment.

Multiple Orthokeratinized Odontogenic Cysts: A Report of Two Cases and Review of the Literature

“…There is a male predominance and the majority of cases were associated with unerupted teeth, which is in agreement with our findings and previous studies [7]. All the cases were treated conservatively and two reported no recurrences [14,17].…”

“…At the present time however, there is no convincing evidence to link multiple OOCs to NBCCS or Gardner Syndrome. Table 1 summarises four previous reports of bilateral or multiple OOCs reported in the literature [14,[16][17][18]. Similar to the cases reported here, the patients were of a relatively young age, with three of the four reports involving an individual in their third decade.…”

Orthokeratinized odontogenic cyst with calcification: A rare case report of a distinct entity

“…Although the histogenesis of OOC is unclear, it is suggested that (a) OOCs could be dentigerous cysts with orthokeratinization as reduced enamel epithelium after tooth formation has the capacity to keratinize under appropriate stimuli, (b) OOCs may represent central dermoid/epidermoid cysts due to similar histological features, (c) OOCs may arise from oral epithelium under the influence of dental papilla or only the oral epithelium and (d) sequestration of the stomodeal ectoderm into the developing jaw during embryogenesis may be a source of origin of OOC. [ 2 5 8 ]…”

“…[ 2 ] Multilocular and bilateral cases also have been reported. [ 2 8 ] Most of the OOCs show striking feature of buccolingual expansion. [ 4 10 ] This helps to differentiate it from OKC which shows anteroposterior growth pattern without causing obvious bone expansion.…”

Bilateral orthokeratinized odontogenic cyst: A rare case report and review

“…Immunohistochemical findings in OOC confirm their non-aggressive behavior when compared to KCOT. [ 7 ] An immunohistochemical analysis of present case was done for proliferative activity by Ki-67 [ Figure 7 ] and anti-apoptotic activity by bcl-2 [ Figure 8 ]. Ki 67 was positive in few cells of basal layer and bcl-2 expression was negative.…”