Mannose binding lectin genes (MBL2) polymorpshisms and the periodontal disease in diabetic patients

Abstract

Purpose: To assess the association between the polymorphism in exon-1 of the MBL2 gene and the periodontal disease in type 2 diabetic patients. Methods: The sample comprised of 100 patients, who were submitted to a clinical periodontal examination that evaluated in six sites per tooth the probing depth (PD), bleeding on probing (BOP), clinical attachment loss (CAL), plaque index (PI) and the number of teeth present. Periodontal disease was defined as at least four sites with loss of attachment of ≥5 mm, with one or more of those sites having a pocket of ≥ 4 mm. The collection of scaling cells from the oral mucosa was carried out and the detection of MBL2 polymorphism was made by real time PCR and melting temperature curve analysis. Results: In a type 2 diabetic population, no significant statistical differences in MBL2 polymorphisms genotype or allele frequencies were observed among subjects with periodontal disease. Conclusion: This study indicates that the polymorphisms in exon-1 of the MBL2 gene are not related to periodontal disease in a type 2 diabetic population.

Association of the Risk of Dental Caries and Polymorphism of <b><i>MBL2</i></b> rs11003125 Gene in Iranian Adults

“…Furthermore, MBL2 plays a critical role in the immune system and produces primary immune response to pathogens. [Araújo et al, 2011;Zimmer et al, 2014]. In recent years, there is evidence showing that MBL2 has an important role in many diseases.…”

Avaliação periodontal em crianças e adolescentes com Diabetes Mellitus tipo 1: estudo caso-controlo

“…6,9 -12 A elevação plasmática de citocinas, por outro lado, é capaz de promover resistência à insulina, o que pode comprometer as condições gerais do paciente. [12][13][14][15][16][17][18][19][20][21][22][23][24] Uma melhor compreensão das manifestações bucais nestes pacientes, desde a infância, pode orientar a intervenção odontológica precoce, minimizando riscos e facilitando os tratamentos. Através do estudo caso -controlo, buscou -se identificar a condição periodontal de crianças e adolescentes com DM1, e comparar resultados com pacientes sem diabetes.…”