Streptococcus mutans in denture stomatitis patients under antifungal therapy

Abstract

Purpose: To assess the number of Streptococcus mutans in saliva of patients with denture stomatitis before and after antifungal therapy.Methods: After examining 93 patients, 47 were selected for fungal test. Then, from this sample, thirty patients were selected: 15 with positive and 15 with negative diagnosis for candidiasis that were evaluated for S. mutans counting, salivary flow and buffer capacity evaluation. Oral hygiene and prosthesis hygiene, period using prosthesis, lesion type and salivary data were related with clinical laboratorial characteristics of the patients with Candida.Results: The most frequent lesions were type I (43.5%) and II (53.5%). The amount of S. mutans was six times higher in patients with candidiasis and it was associated with low salivary flow and poor oral hygiene. After therapy, a reduction of S. mutans was verified particularly in patients with normal salivary flow. The values ranged from 0.01 to 3.88 x 10 4 cfu/mL.Conclusion: The data suggest that Streptococcus spp collaborates with Candida spp in the etiology and pathogenesis of denture stomatitis. The use of oral antimicrobial agents may provide a beneficial effect for denture stomatitis patients that are under antifungal therapy and that have poor oral hygiene and unfavorable salivary parameters.Key words: Dental prosthesis; antifungal agents; Candida; Streptococcus mutans ResumoObjetivo: Verificar o número de Streptococcus mutans em saliva de pacientes com estomatite protética antes e após a terapia antifúngica.Metodologia: Após exame clínico de 93 pacientes, 47 foram selecionados para exame micológico e desta amostra foram selecionados trinta pacientes: 15 com diagnóstico positivo e 15 com diagnóstico negativo de candidose foram avaliados para contagem de S. mutans, determinação de fluxo salivar e capacidade tampão. Higiene bucal e da prótese, tempo de confecção, tipo de lesão e dados salivares foram relacionados com características clínicas e laboratoriais de Candida.Resultados: As lesões frequentes foram dos tipos I (43,5%) e II (53,5%). A quantidade de S. mutans foi seis vezes maior em pacientes com candidose e foi associada com baixo fluxo salivar e higiene oral deficiente. Após a terapia, a redução de S. mutans foi verificada particularmente em pacientes com fluxo salivar normal. Os valores variaram de 0,01 a 3,88 UFC/ml x 10 4 .Conclusão: Os dados sugerem que os Streptococcus colaboram com Candida spp na etiopatogenia da estomatite protética. O uso de agentes antimicrobianos orais pode propiciar efeito benéfico para pacientes com estomatite protética submetidos à terapia antifúngica e que apresentam higiene oral deficiente e parâmetros salivares desfavoráveis.

Efektivitas Ekstrak Biji Srikaya (Annona squamosa L.) sebagai Bahan Pembersih Gigi Tiruan terhadap Daya Hambat Pertumbuhan Streptococcus mutans pada Basis Akrilik Heat Cured

“…Prevalensi denture stomatitis berkisar antara 30-50% pada pengguna gigi tiruan lengkap, dengan penderita biasa ditemukan pada lanjut usia dan lebih banyak ditemukan pada wanita [9]. Adhesi jamur maupun bakteri pada epitel rongga mulut merupakan tahap pertama dalam kolonisasi mikroba, dimana bakteri S.mutans merupakan inisiator pembentukan biofilm dan memfasilitasi adhesi mikroba ke mukosa maupun permukaan gigi tiruan [10]. S.mutans mensintesis sukrosa menjadi substrat polisakarida ekstraseluler berupa dekstran atau levan yang lengket, sehingga menyediakan media bagi jamur maupun bakteri lain untuk menempel pada basis gigi tiruan [11].…”

Evaluation of the Antifungal Effect Vitis vinifera Extract on Candida albicans

“…Furthermore, some patients are presented as asymptomatic to the infection; however, they normally report various symptoms, as pain, swelling, xerostomia, halitosis and bleeding, symptoms that many times impossible the prosthesis use. 4,7,8 The predisposition to candidiasis is favorable by a range of systemic factors that, directly or indirectly, take to an immunossuppression, as: cancer, prolonged antibiotic therapy; xerostomia; innutrition, age (mainly elderly and children); diabetes; AIDS (Acquired Immunodeficiency Syndrome) and pregnancy. However, local factors can also contribute, among them, the smoking; pre-existing diseases on the oral mucous; precarious hygiene and bad use or maintenance of the dental prosthesis.…”

Antimicrobial Activity of Chitosan 2% and Oxygenizing Denture Cleanser on Prohibiting Streptococcus Mutans Growth at Acrylic Heat-Cured Resins Plate

“…Streptococcus mutans is a frequent member of acrylic denture base surfaces. 6,7 To avoid denture stomatitis, patients use a wide variety of agents for cleaning dentures. The most common commercial products are based upon immersion techniques, which is oxygenizing denture cleanser.…”