A population-based study of cognitive impairment in socially vulnerable adults in Argentina. The Matanza Riachuelo Study. Preliminary Results

Bartoloni, Leonardo; Blatt, Graciela; Insúa, Iván; Furman, Mariano; M, González; Hermann, B.P.; Kesselman, Mariana; Massautis, Alicia; Reinado, Alejandra; Senas, Patricia; Yavitz, Claudia; Lejarraga, Horacio; Nunes, Fernando M.; Arizaga, Raúl Luciano; Allegri, Ricardo

doi:10.1590/s1980-57642014dn84000006

Cited by 14 publications

(23 citation statements)

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“…As Table 1 illustrates, the majority of the studies (four) were conducted in South America ( 25 , 26 , 29 ), two were based in the Caribbean ( 23 , 24 ), and one in Central America ( 27 ). With the exception of the Central American study, all studies had adopted a 2-stage design that involved initial screening by field workers and case confirmation by medical specialists (see Table 1 ).…”

Section: Resultsmentioning

confidence: 99%

Systematic Review Estimating the Burden of Dementia in the Latin America and Caribbean Region: A Bayesian Approach

et al. 2021

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Background: The global burden of dementia has increasingly shifted to low- and middle-income regions that lack essential data for monitoring epidemiological progression, and policy and planning support. Drawing upon data that have emerged since the last known estimates published in 2015, this study aims to update dementia estimates in the Latin America and Caribbean (LAC) region for the years 2020, 2030, and 2050 through the application of a recently validated Bayesian approach for disease estimates useful when data sources are scarce.Methods: A comprehensive parallel systematic review of PubMed, EMBASE, PsycINFO, Global Health, and LILACS was conducted to identify prospective population-based epidemiological studies on dementia published in English from 2013 to 2018 in LAC. English and non-English data cited by a recent review on dementia estimates in LAC were also examined for additional data. A Bayesian normal-normal hierarchical model (NNHM) was developed to estimate age-specific and age-adjusted dementia prevalence in people aged 60+. Using age-specific population projections from the UN, the total number of people affected by dementia for the years 2020, 2030, and 2050 were estimated.Results: 1,414 studies were identified, of which only 7 met the inclusion criteria. The studies had 7,684 participants and 1,191 dementia cases. The age-standardized prevalence of all forms of dementia in LAC was 8% (95% CI: 5–11.5%) in people aged 60+. The estimated prevalence varied with age, increasing from 2.5% (95% CI: 0.08–4.0%) in the 60-69 age group, to 9.4% (95% CI: 5.4–13.2%) in the 70–79 age group and 28.9% (95% CI: 20.3–37.2%) in the ≥80 age group. The number of people age 60 and older living with dementia in LAC in 2020 was estimated at 6.86 (95% CI: 4.3–9.8) million, 9.94 (95% CI: 6.16–14.15) million in 2030, and 19.33 (95% CI: 12.3–13.6) million in 2050.Conclusion: We project an upward disease trajectory for dementia in LAC countries. The projection is likely an underestimation of the true dementia burden given the underrepresentation of rural and socio-economically deprived populations. More research is urgently needed to improve the accuracy of disease estimates, guide clinicians to improve evaluations for earlier recognition of dementia, and support the development of effective policies for improving dementia prevention, diagnosis and clinical management in LAC's diverse and aging communities.

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Section: Resultsmentioning

confidence: 99%

Systematic Review Estimating the Burden of Dementia in the Latin America and Caribbean Region: A Bayesian Approach

et al. 2021

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“…All but four studies (Bartoloni et al, 2014;Correa Ribeiro et al, 2013;Pedraza et al, 2017;Villarreal et al, 2016) did not include representative sample frames to address the target population. Bartoloni et al (2014) (Villarreal et al, 2019). Although five articles were classified as unclear regarding the appropriateness of recruited participants (Brucki & Nitrini, 2014;Correia et al, 2011;Lopes et al, 2012;Pedraza et al, 2017;Ramos-Cerqueira et al, 2005), all articles presented adequate sample size.…”

Section: Methodological Quality Of the Included Studiesmentioning

confidence: 99%

Section: Methodological Quality Of the Included Studiesmentioning

confidence: 99%

“…Although five articles were classified as unclear regarding the appropriateness of recruited participants (Brucki & Nitrini, 2014;Correia et al, 2011;Lopes et al, 2012;Pedraza et al, 2017;Ramos-Cerqueira et al, 2005), all articles presented adequate sample size. Moreover, in 11 studies, it was not clear whether dementia was assessed in a standardised way, i.e., whether those involved in data collection were trained in the use of the instruments (Albala et al 1997 Regarding the appropriateness of the statistical analysis, 14 articles did not report confidence intervals (Albala et al 1997;Bartoloni et al, 2014;Brucki & Nitrini, 2014;Caramelli et al, 2011;Eldemire-Shearer et al 2018;Gooding et al, 2006;Herrera et al, 2002;Ketzoian et al 1997a;Macías Ortega et al, 2012;Manrique-Espinoza et al, 2013;Martínez Querol et al, 2005;Neita et al, 2014;Ramos-Cerqueira et al, 2005;Villarreal et al, 2016).…”

Section: Methodological Quality Of the Included Studiesmentioning

confidence: 99%

“…Studies differed on whether they assessed dementia in one phase, with a one-time full assessment or two or more phases, with an initial screening phase and subsequent in-depth assessment of participants with probable dementia (the pooled prevalence by the number of diagnostic phases is provided in supplementary material Figure S1). Thirteen out of the 32 included studies conducted a two phases-diagnosis (Albala et al, 1997;Bartoloni et al, 2014;Bottino et al, 2008;Brucki & Nitrini, 2014;Correa Ribeiro et al, 2013;Correia et al, 2011;Gooding et al, 2006;Ketzoian et al, 1997;Llibre et al, 2009;Lopes et al, 2012;Neita et al, 2014;Pedraza et al, 2017;Ramos-Cerqueira et al, 2005) and four studies conducted more than two phases-diagnosis to identify patients with dementia (Caramelli et al, 2011;Custodio et al, 2008;Herrera et al, 2002;Molero et al, 2007). In general, MMSE was used as the main instrument to screen symptoms of dementia; however, the following phases varied widely among studies in terms of instruments used.…”

Section: Study Selection Processmentioning

confidence: 99%

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Systematic review and meta-analyses on the prevalence of dementia in Latin America and Caribbean countries: Exploring sex, rurality, age, and education as possible determinants

Ribeiro

Teixeira-Santos

Caramelli

et al. 2021

Preprint

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Background: Studies have shown that the prevalence of dementia in Latin America and the Caribbean (LAC) may be higher than in high-income countries. Thus, we sought to systematically analyse the prevalence of dementia and explore possible drivers that lead to this disparity in LAC countries. Method: We searched Pubmed, Web of Knowledge, Scopus, Lilacs, and SciELO for studies on dementia in LAC countries in English, Spanish, and Portuguese languages. Random-effects model was applied. Results: Twenty-nine studies from 12 LAC countries were included. Pooled prevalence of all-cause dementia was 11%. Further analyses with studies providing raw prevalence by sex, area, and educational level showed a higher prevalence for women (9%) than for men (5%). Also, dementia prevalence was higher for rural than urban residents (12% vs 8%, respectively). Participants without formal education presented more than double the prevalence of dementia (22%) compared to those with at least one year of formal education (10%). Studies with more recent data collection showed higher dementia prevalence. Conclusion: Our findings suggest a high global dementia prevalence in LAC countries and an unequal burden of dementia for women, lower-educated, and rural residents. Secular raises in dementia prevalence call for increased public health efforts for preventative action.

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Global Prevalence of Young-Onset Dementia

Hendriks

Peetoom

Bakker³

et al. 2021

JAMA Neurol

183

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A population-based study of cognitive impairment in socially vulnerable adults in Argentina. The Matanza Riachuelo Study. Preliminary Results

Cited by 14 publications

References 15 publications

Systematic Review Estimating the Burden of Dementia in the Latin America and Caribbean Region: A Bayesian Approach

Systematic Review Estimating the Burden of Dementia in the Latin America and Caribbean Region: A Bayesian Approach

Systematic review and meta-analyses on the prevalence of dementia in Latin America and Caribbean countries: Exploring sex, rurality, age, and education as possible determinants

Global Prevalence of Young-Onset Dementia

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