Differential diagnosis between dementia and psychiatric disorders: Diagnostic criteria and supplementary exams Recommendations of the Scientific Department of Cognitive Neurology and Aging of the Brazilian Academy of Neurology

Bottino, Cássio M.C.; Pádua, Analuiza Camozzato de; Smid, Jerusa; Fegyveres, Renata Areza; Novaretti, Tânia Maria da Silva; Bahia, Valéria Santoro

doi:10.1590/s1980-57642011dn05040006

Cited by 8 publications

(7 citation statements)

References 66 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Various, depending on the diagnosis. Memory complaints, depressive or anxious mood, altered sleep cycles, slowed processing speeds, executive dysfunction, difficulty concentrating, worry, irritability, fatigue, muscle tension [30,31].…”

Section: Primary Psychiatric Disordermentioning

confidence: 99%

Alzheimer’s Disease-Related Metabolic Pattern in Diverse Forms of Neurodegenerative Diseases

et al. 2021

View full text Add to dashboard Cite

Dementia is broadly characterized by cognitive and psychological dysfunction that significantly impairs daily functioning. Dementia has many causes including Alzheimer’s disease (AD), dementia with Lewy bodies (DLB), and frontotemporal lobar degeneration (FTLD). Detection and differential diagnosis in the early stages of dementia remains challenging. Fueled by AD Neuroimaging Initiatives (ADNI) (Data used in preparation of this article were obtained from the Alzheimer’s Disease Neuroimaging Initiative (ADNI) database. As such, the investigators within ADNI contributed to the design and implementation of ADNI and/or provided data but did not participate in analysis or writing of this report.), a number of neuroimaging biomarkers for AD have been proposed, yet it remains to be seen whether these markers are also sensitive to other types of dementia. We assessed AD-related metabolic patterns in 27 patients with diverse forms of dementia (five had probable/possible AD while others had atypical cases) and 20 non-demented individuals. All participants had positron emission tomography (PET) scans on file. We used a pre-trained machine learning-based AD designation (MAD) framework to investigate the AD-related metabolic pattern among the participants under study. The MAD algorithm showed a sensitivity of 0.67 and specificity of 0.90 for distinguishing dementia patients from non-dementia participants. A total of 18/27 dementia patients and 2/20 non-dementia patients were identified as having AD-like patterns of metabolism. These results highlight that many underlying causes of dementia have similar hypometabolic pattern as AD and this similarity is an interesting avenue for future research.

show abstract

Section: Primary Psychiatric Disordermentioning

confidence: 99%

Alzheimer’s Disease-Related Metabolic Pattern in Diverse Forms of Neurodegenerative Diseases

et al. 2021

View full text Add to dashboard Cite

show abstract

“…3 Indeed, declining processing speed, reduced processing resources, and decreased cognitive control may account for age-related memory complaints. 2 On the other hand, memory loss is a frequent symptom in different neuropsychiatric disorders, including dementias and psychiatric disorders, 4 and is also found in systemic conditions (e.g., hypothyroidism and vitamin B12 deficiency). 5 Previous studies investigated the prevalence of memory complaints in different populations.…”

Section: Introductionmentioning

confidence: 99%

Memory complaints at primary care in a middle-income country: clinical and neuropsychological characterization

Pereira

Vasconcelos

Oliveira

et al. 2021

Dement. neuropsychol.

View full text Add to dashboard Cite

ABSTRACT. There are different causes of memory complaints in the elderly, such as subjective cognitive decline (SCD), mild cognitive impairment (MCI) or dementia. Objective: 1) To characterize individuals with memory complaints in a mid-sized city in Brazil, through clinical, cognitive and functional assessment; 2) to compare SCD individuals with MCI and dementia patients in terms of clinical and cognitive variables. Methods: We consecutively included individuals aged ≥50 years, with memory complaints (spontaneous or inquired). Subjects who scored ≥25 on the Memory Complaint Questionnaire or who had spontaneous memory complaints were selected. Participants underwent a semi-structured interview, the Mini-Mental State Examination, Figure Memory Test for visual episodic memory, Clock Drawing Test, Category Fluency (Animals), Neuropsychiatric Inventory, and functional assessment. Individuals were classified as SCD, MCI or dementia. We did not include individuals with previous diagnosis of dementia. Results: The final sample consisted of 91 subjects (73.6% women; mean age 67.6±9.8 years): 14.3% had spontaneous complaints and 85.7% had inquired complaints. The most common comorbidities were hypertension (69.2%), diabetes (36.3%), and dyslipidemia (24.2%). Low levels of vitamin B12 and hypothyroidism were found in 26.4 and 16.5%, respectively. Regarding cognitive diagnosis, 16.5% of the sample were classified as SCD, 49.4% as MCI and 34.1% as dementia. MCI and dementia were identified in five (38.5%) and seven (53.4%) patients with spontaneous complaint, respectively. Conclusions: MCI and dementia are frequently underdiagnosed. Potential reversible causes of cognitive decline are common. The diagnosis of dementia is highly frequent among individuals with spontaneous memory complaints.

show abstract

“…Contudo, sabe-se que a diminuição de monoaminas, como a dopamina, a serotonina e a norepinefrina estão relacionados com a fisiopatologia desse transtorno, além da exposição a condições ambientais adversas, assim como algum evento de estresse emocional e traumas ocorridos na infância. 4,5,6 Além disso, estudos sugerem que a composição genética pode estar intimamente associada à ocorrência de quadros psicopatológicos, devido, principalmente, à grande quantidade de genes encontrados e que estão associados ao temperamento afetivo e distúrbios do humor como depressão e ansiedade. 7,8 Estudos têm mostrado que o risco relativo para familiares de primeiro grau de indivíduos portadores de depressão é de duas a três vezes maior do que para os que não possuem história familiar de depressão e, em gêmeos, a correlação pode chegar a 40%.…”

unclassified

Associação dos polimorfismos rs53576 e rs2254298 do gene receptor da ocitocina com depressão: uma revisão sistemática

Jacondino

Borges

Gottlieb

2014

Sci Med

View full text Add to dashboard Cite

RESUMOObjetivos: Embora a etiologia da depressão seja reconhecidamente multifatorial, estudos têm sugerido que esteja associada a uma mutação no gene receptor da ocitocina (OXTR). O objetivo deste estudo foi verificar, por meio de uma revisão sistemática da literatura, a ocorrência de associação dos OXTR rs53576 e rs2254298 com depressão e sintomas ou temperamento depressivo. Métodos: A pesquisa foi realizada nas bases Lilacs, PubMed, SciELO, Web of Science, Scopus e Embase, abrangendo o período de 2004 a 2014, nos idiomas inglês e português, com o descritor gene receptor da ocitocina/oxytocin receptor gene, adicionado aos descritores depressão/ depression, temperamento depressivo/depressive temperament ou distúrbios do humor/mood disorder. Foram utilizados os seguintes critérios para a inclusão dos artigos: estudos originais com conteúdo disponível na íntegra em idioma inglês ou português; somente estudos com seres humanos com diagnóstico clínico de depressão, ou rastreamento de sintomas e temperamento depressivos; estudos com as variantes rs53576 ou rs225298 do gene OXTR; e a investigação de associação entre os polimorfismos OXTR e depressão e/ou sintomas ou temperamento depressivo. Resultados: Foram capturados inicialmente 126 artigos, entretanto apenas oito estudos preencheram os critérios de inclusão. Dos oito artigos incluídos, seis estudos encontraram associação significativa entre as variantes OXTR rs53576 e rs2254298 com depressão, temperamento e sintomas depressivos, enquanto dois estudos não encontraram associação. Conclusões: Os resultados sugerem que os OXTR rs53576 e rs2254298 estão associados a sintomas, temperamento depressivo e depressão. Contudo, é importante levar em consideração que esses polimorfismos não atuam de forma determinística, ou seja, são influenciados ou modulados por condições ambientais, que podem envolver fatores biopsicossociais, afetivos, étnicos e de gênero. DESCRITORES: RECEPTORES DA OCITOCINA; OXTR; POLIMORFISMO GENÉTICO; OCITOCINA; DEPRESSÃO. ABSTRACT Aims:Although the etiology of depression is known to be multifactorial, studies have pointed to its association with a mutation in the oxytocin receptor gene (OXTR). The aim of this study was to determine, by means of a systematic review of the literature, whether OXTRs rs53576 and rs2254298 are associated with depression and depressive symptoms or temperament. Methods: The survey was conducted on the databases Lilacs, PubMed, SciELO, Web of Science, Scopus and Embase, covering the period 2004-2014, in English and Portuguese, with the descriptors receptor da ocitocina/oxytocin receptor gene, added to depressão/depression, temperamento depressivo/depressive temperament, or distúrbios do humor/mood disorder. The following criteria were used for the inclusion of items: original studies with content available in full in English or Portuguese language; only human studies with clinical diagnosis of depression, or screening for symptoms and depressive temperament; studies on the variants rs53576 or rs22524298 of OXTR; and search fo...

show abstract

Differential diagnosis between dementia and psychiatric disorders: Diagnostic criteria and supplementary exams Recommendations of the Scientific Department of Cognitive Neurology and Aging of the Brazilian Academy of Neurology

Cited by 8 publications

References 66 publications

Alzheimer’s Disease-Related Metabolic Pattern in Diverse Forms of Neurodegenerative Diseases

Alzheimer’s Disease-Related Metabolic Pattern in Diverse Forms of Neurodegenerative Diseases

Memory complaints at primary care in a middle-income country: clinical and neuropsychological characterization

Associação dos polimorfismos rs53576 e rs2254298 do gene receptor da ocitocina com depressão: uma revisão sistemática

Contact Info

Product

Resources

About