Associação dos polimorfismos rs53576 e rs2254298 do gene receptor da ocitocina com depressão: uma revisão sistemática

Jacondino, Camila Bittencourt; Borges, Cristiane Alves; Gottlieb, Maria Gabriela Valle

doi:10.15448/1980-6108.2014.4.18173

Cited by 3 publications

(2 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Other findings centered on OXTr rs2254298 show that autistic traits are related to this polymorphism, but only when it is comprised in a haplotype (Lerer et al, 2008 ; Mosconi et al, 2009 ; Nyffeler et al, 2014 ; Francis et al, 2016 ). Besides autism, rs2254298 was also linked to social impairment in general (Parker et al, 2014 ), empathy (Wu et al, 2012 ) anxiety and depression (Mosconi et al, 2009 ; Thompson et al, 2011 ; Bittencourt Jacondino et al, 2014 ).…”

Section: Methodsmentioning

confidence: 99%

A Review of Oxytocin and Arginine-Vasopressin Receptors and Their Modulation of Autism Spectrum Disorder

Cataldo

Azhari

Esposito

2018

Front. Mol. Neurosci.

View full text Add to dashboard Cite

Oxytocin (OXT) and arginine-vasopressin (AVP) play a key regulatory part in social and affiliative behaviors; two aspects highly compromised in Autism Spectrum Disorder (ASD). Furthermore, variants in the adjacent oxytocin-vasopressin gene regions have been found to be associated with ASD diagnosis and endophenotypes. This review focuses mainly on common OXTr single nucleotide polymorphisms (SNPs), AVPR1a microsatellites and AVPR1b polymorphisms in relation to the development of autism. Although these genes did not surface in genome-wide association studies, evidence supports the hypothesis that these receptors and their polymorphisms are widely involved in the regulation of social behavior, and in modulating neural and physiological pathways contributing to the etiology of ASD. With a specific focus on variants considered to be among the most prevalent in the development of ASD, these issues will be discussed in-depth and suggestions to approach inconsistencies in the present literature will be provided. Translational implications and future directions are deliberated from a short-term and a forward-looking perspective. While the scientific community has made significant progress in enhancing our understanding of ASD, more research is required for the ontology of this disorder to be fully elucidated. By supplementing information related to genetics, highlighting the differences across male and female sexes, this review provides a wider view of the current state of knowledge of OXTr and AVPr mechanisms of functioning, eventually addressing future research in the identification of further risk factors, to build new strategies for early interventions.

show abstract

Section: Methodsmentioning

confidence: 99%

A Review of Oxytocin and Arginine-Vasopressin Receptors and Their Modulation of Autism Spectrum Disorder

Cataldo

Azhari

Esposito

2018

Front. Mol. Neurosci.

View full text Add to dashboard Cite

show abstract

“…Os fatores biológicos são sustentados por alterações químicas no cérebro do indivíduo acometido, mais especificamente os neurotransmissores e receptores 4 . Quanto ao fator genético, existem estudos psiquiátricos que evidenciam maior frequência deste distúrbio em certas famílias 5 e que o risco para familiares de primeiro grau de portadores do quadro é de duas a três vezes maior 6 . Já os fatores psicossociais estão relacionados ao modo como a pessoa percebe e interpreta os acontecimentos da vida, como lida com seus próprios sentimentos e principalmente com o estresse das pressões sociais 4 .…”

Section: Introductionunclassified

A sintomatologia depressiva entre lésbicas, gays, bissexuais e transexuais: um olhar para a saúde mental

2019

View full text Add to dashboard Cite

Objetivos: analisar a incidência da sintomatologia depressiva entre lésbicas, gays, bissexuais e transexuais (LGBT), de dois cenários distintos, e sua relação com a sexualidade desses indivíduos. Método: pesquisa quantitativa, mediante análise estatística, realizada entre os anos de 2016 a 2018, e que aplicou o Inventário de Depressão de Beck - II (BDI- II) do Hospital Uiversitário Gaffrée e Guinle (HUGG) e na Escola de Enfermagem Alfredo Pinto (EEAP), ambos localizados no município do Rio de Janeiro. Participaram 76 pessoas. A pesquisa foi aprovada por Comitê de Ética. Resultados: No HUGG foi observado indicativo de depressão mínima. Na EEAP, foi observado indicativo de depressão moderada. As disparidades podem ser justificadas pela diferença de idade, os impactos do processo de disclosure e estigmas do portador de HIV. Conclusão: observou-se que a família é fundamental na saúde mental entre LGBT e que é necessário mais pesquisas sobre o tema.

show abstract

Association of Oxytocin Receptor Gene (OXTR) rs53576 Polymorphism with Sociality: A Meta-Analysis

et al. 2015

View full text Add to dashboard Cite

A common variant in the oxytocin receptor gene (OXTR), rs53576, has been broadly linked to socially related personality traits and behaviors. However, the pattern of published results is inconsistent. Here, we performed a meta-analysis to comprehensively evaluate the association. The literature was searched for relevant studies and effect sizes between individuals homozygous for the G allele (GG) and individuals with A allele carriers (AA/AG). Specifically, two indices of sociality were evaluated independently: i) general sociality (24 samples, n = 4955), i.e., how an individual responds to other people in general; and ii) close relationships (15 samples, n = 5262), i.e., how an individual responds to individuals with closed connections (parent-child or romantic relationship). We found positive association between the rs53576 polymorphism and general sociality (Cohen’s d = 0.11, p = .02); G allele homozygotes had higher general sociality than the A allele carriers. However, the meta-analyses did not detect significant genetic association between rs53576 and close relationships (Cohen’s d = 0.01, p = .64). In conclusion, genetic variation in the rs53576 influences general sociality, which further implies that it is worthy to systematically examine whether the rs53576 is a valid genetic marker for socially related psychiatric disorders.

show abstract

Associação dos polimorfismos rs53576 e rs2254298 do gene receptor da ocitocina com depressão: uma revisão sistemática

Cited by 3 publications

References 42 publications

A Review of Oxytocin and Arginine-Vasopressin Receptors and Their Modulation of Autism Spectrum Disorder

A Review of Oxytocin and Arginine-Vasopressin Receptors and Their Modulation of Autism Spectrum Disorder

A sintomatologia depressiva entre lésbicas, gays, bissexuais e transexuais: um olhar para a saúde mental

Association of Oxytocin Receptor Gene (OXTR) rs53576 Polymorphism with Sociality: A Meta-Analysis

Contact Info

Product

Resources

About