Detecting cognitive impairment in patients with Parkinson's disease using a brief cognitive screening tool: Addenbrooke's Cognitive Examination (ACE)

Chade, Anabel; Roca, María; Torralva, Teresa; Gleichgerrcht, Ezequiel; Fabbro, Nicolás; Arévalo, Gonzalo Gómez; Gershanik, Oscar S.; Manes, Facundo

doi:10.1590/s1980-57642009dn20300006

Cited by 13 publications

(9 citation statements)

References 19 publications

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“…In addition, ACE-R has been shown to have a greater diagnostic sensitivity and specificity than MMSE in diseases such as Parkinson disease (PD) [16, 17], AD [18, 19], behavioral variant frontotemporal dementia (bvFTD) [19, 20], vascular dementia [18], and dementia with Lewy bodies [19]. …”

Section: Introductionmentioning

confidence: 99%

Validation of the Cuban Version of Addenbrooke’s Cognitive Examination-Revised for Screening Mild Cognitive Impairment

Broche-Pérez¹,

López-Pujol²

2017

Dement Geriatr Cogn Disord

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Background/Aims: The diagnostic accuracy of the Cuban version of the revised Addenbrooke’s Cognitive Examination (ACE-R) in identifying mild cognitive impairment (MCI) in comparison with the Mini-Mental State Examination (MMSE) was assessed. Methods: The Cuban ACE-R was administered to a group of 129 elderly subjects (92 cognitively healthy and 37 subjects with MCI). The t tests for independent samples were used to compare scores of different psychometric scales between groups, and effect sizes (Cohen’s d) were calculated. Cronbach’s coefficient α was used to evaluate the reliability of psychometric scales. The validity of ACE-R to screen for MCI was assessed by receiver operating characteristic (ROC) curves. Results: The Cuban ACE-R had reliable internal consistency (Cronbach’s coefficient α = 0. 879). The optimal cut-off score for ACE-R for detecting MCI was 84/85. The sensitivity and specificity of ACE-R to screen for MCI was superior to those of MMSE. The area under the ROC curve of the Cuban ACE-R was much larger than that of MMSE (0.93 and 0.63) for detecting MCI. Conclusion: The Cuban ACE-R is a valid screening tool for detecting cognitive impairment. It is more sensitive and accurate in screening for MCI than MMSE.

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Section: Introductionmentioning

confidence: 99%

Validation of the Cuban Version of Addenbrooke’s Cognitive Examination-Revised for Screening Mild Cognitive Impairment

Broche-Pérez¹,

López-Pujol²

2017

Dement Geriatr Cogn Disord

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“…The ACE-R Verbal Fluency domain distinguishes between PSP and PD with high sensitivity (0.92) and high specificity (0.87), and the total ACE-R score have specificity 0.87 and sensitivity 0.7 and visuospatial subscore have a specificity 0.84 and sensitivity 0.73 [11]. The sensitivity of ACE-R for detection of cognitive decline in PD was confirmed in another study that showed a performance difference on the ACE-R total score between PD and healthy controls [12]. The ability of ACE-R to detect Addenbrooke's Cognitive Examination in Nondemented Patients after Stroke (iADL) scales; and signed, informed consent.…”

Section: Patientsmentioning

confidence: 83%

Addenbrooke’s Cognitive Examination in Nondemented Patients after Stroke

Fiedorová¹,

Krulová²,

Ressner³

et al. 2018

Neuropsychiatry

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Introduction:Cognitive deficit after stroke is common, and beginning cognitive rehabilitation as soon as possible is important to minimize the consequences of the impairment. The aim of this study was to use Addenbrooke's Cognitive Examination to compare cognitive function in nondemented and nondepressed stroke patients, 3-6 months after the stroke, with sex-and age-matched controls. Materials and Methods:A total of 156 participants were included (72 controls: 19 men, mean age 64.5 ± 12.4 years; 84 patients after stroke: 54 men, mean age 62.2 ± 9.0 years).Results: Statistically significant differences were identified between controls and stroke patients in total Addenbrooke's score (stroke patients, 86.2 points vs controls, 91.2 points; p<0.01), Verbal Production domain (stroke patients, 9.8 points vs controls, 11.5 points; p<0.01), and Memory domain (stroke patients, 19.5 points vs controls, 21.7 points; p<0.01). The difference was also statistically significant between subgroups of stroke patients and controls: patients with a right-sided brain lesion differed from controls in total scores (88.3 vs 91.3 points, respectively; p<0.05) and Verbal Production domain scores (9.9 vs 11.5 points, p<0.01), as did patients with left-sided brain lesions in total score (83.9 vs 91.3 points; p<0.01) and Memory (18.6 vs 21.7 points; p<0.01) and Verbal Production (9.6 vs 11.5 points; p<0.01) domains. Conclusion:This study shows the usability of Addenbrooke's Cognitive Examination 3-6 months after a stroke to detect mild cognitive decline, providing a basis for initiating cognitive rehabilitation as soon as possible.

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“…ACE-I also includes the nested version of MMSE. The Spanish version of ACE-I was able to detect dementia in PD, and it could discriminate PDD from Alzheimer's dementia but not from frontotemporal dementia [ 27 ].…”

Section: Introductionmentioning

confidence: 99%

Comparing Sensitivity and Specificity of Addenbrooke’s Cognitive Examination-I, III and Mini-Addenbrooke’s Cognitive Examination in Parkinson’s Disease

Lucza

Ascherman

Kovács

et al. 2018

Behavioural Neurology

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Background Parkinson's disease (PD) is the second most common neurodegenerative disorder characterized by numerous motor and nonmotor symptoms. Neurocognitive disorders (NCD) are one of the most troublesome problems and their diagnosis is often challenging. Methods We compared the sensitivity and specificity of several versions of Addenbrooke Cognitive Examination (ACE, ACE-III, and Mini-ACE) on 552 subjects with PD. Normal cognition, mild and major NCD were judged in accordance with the respective criteria of the Diagnostic and Statistical Manual of Mental Disorders 5th edition. Subsequently, we applied the receiver operation characteristic (ROC) analysis in comparison of different education levels. Results For subjects with education level 0–8 and 9–12 years, the ACE-III had the best discriminating capabilities for mild NCD (cut-off scores: 83.5 and 85.5 points, respectively), while Mini-ACE was the best for subjects having education > 12 years (cut-off score: 25.5 points). For detecting major NCD, ACE-III had the best diagnostic accuracy in all levels of education (cut-off scores: 70.5, 77.5, and 78.5 points for subjects having education level 0–8, 9–12, and >12 years, respectively). Conclusion ACE-III and its nested version, the Mini-ACE, had the best screening abilities for detecting mild and major NCD in PD.

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Detecting cognitive impairment in patients with Parkinson's disease using a brief cognitive screening tool: Addenbrooke's Cognitive Examination (ACE)

Cited by 13 publications

References 19 publications

Validation of the Cuban Version of Addenbrooke’s Cognitive Examination-Revised for<b></b> Screening<b></b> Mild Cognitive Impairment

Validation of the Cuban Version of Addenbrooke’s Cognitive Examination-Revised for<b></b> Screening<b></b> Mild Cognitive Impairment

Addenbrooke’s Cognitive Examination in Nondemented Patients after Stroke

Comparing Sensitivity and Specificity of Addenbrooke’s Cognitive Examination-I, III and Mini-Addenbrooke’s Cognitive Examination in Parkinson’s Disease

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